Evidence of post-menopausal status or negative urinary or serum pregnancy test for female pre-menopausal patients is required; women will be considered post-menopausal if they have been amenorrheic for  months without an alternative medical cause; the following age-specific requirements apply:\r\n* Women <  years of age would be considered post-menopausal if they have been amenorrheic for  months or more following cessation of exogenous hormonal treatments and if they have luteinizing hormone and follicle stimulating hormone levels in the post-menopausal range for the institution or underwent surgical sterilization (bilateral oophorectomy or hysterectomy)\r\n* Women >=  years of age would be considered post-menopausal if they have been amenorrheic for  months or more following cessation of all exogenous hormonal treatments, had radiation-induced oophorectomy with last menses >  year ago, had chemotherapy-induced menopause with >  year interval since last menses, or underwent surgical sterilization (bilateral oophorectomy or hysterectomy)
Postmenopausal or evidence of non-childbearing status for women of childbearing potential a negative urine or serum pregnancy test within  days of study treatment and confirmed prior to treatment on day ; postmenopausal is defined as:\r\n* Amenorrheic for  year or more following cessation of exogenous hormonal treatments\r\n* Luteinizing hormone (LH )and follicle stimulating hormone (FSH) levels in the post menopausal range for women under \r\n* Radiation-induced oophorectomy with last menses >  year ago\r\n* Chemotherapy-induced menopause with >  year interval since last menses\r\n* Surgical sterilization (bilateral oophorectomy or hysterectomy)
Women of child-bearing potential and men must agree to use highly effective contraception for appropriate methods of contraception) prior to study entry, for the duration of study participation, and for at least  months ( days) after the last dose of study agent; should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately; men treated or enrolled on this protocol must also agree to use two highly effective forms of contraception in combination prior to the study, for the duration of study participation, and for at least  months ( days) after completion of atezolizumab and/or olaparib administration; women of child-bearing potential: negative serum pregnancy test within  days of study treatment and confirmed prior to treatment on day \r\nPostmenopausal or evidence of non-childbearing status for women of childbearing potential; postmenopausal is defined as:\r\n* Amenorrheic for  year or more following cessation of exogenous hormonal treatments\r\n* Luteinizing hormone (LH) and Follicle stimulating hormone (FSH) levels in the post-menopausal range for women under \r\n* Radiation-induced oophorectomy with last menses >  year ago\r\n* Chemotherapy-induced menopause with >  year interval since last menses\r\n* Surgical sterilization (bilateral oophorectomy or hysterectomy)
Women of childbearing potential must have a negative urine or serum pregnancy test within  days of initial dose of olaparib and temozolomide AND must agree to the use of two highly effective forms of contraception throughout their participation in the study and for at least  months after the last dose of olaparib and temozolomide, OR confirmed prior to treatment on day  to be postmenopausal or surgically sterile; postmenopausal is defined as:\r\n* Amenorrheic for  year or more following cessation of exogenous hormonal treatments\r\n* Luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels in the postmenopausal range for women under \r\n* Radiation-induced oophorectomy with last menses >  year ago\r\n* Chemotherapy-induced menopause with >  year interval since last menses, or surgical sterilization (bilateral oophorectomy or hysterectomy)
Post-menopausal or evidence of non-childbearing status for women of childbearing potential; for women who are not post-menopausal, a negative urine or serum pregnancy test is required within  days of study treatment and confirmed prior to treatment on day ; post-menopausal is defined as one of the following:\r\n* >  years old\r\n* Amenorrheic for  year or more following cessation of exogenous hormonal treatments\r\n* Luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels in the post-menopausal range for women under \r\n* Radiation-induced oophorectomy with last menses >  year ago\r\n* Surgical sterilization (bilateral oophorectomy or hysterectomy)
Females should be using adequate contraceptive measures, should not be breast feeding and must have a negative pregnancy test prior to start of dosing if of child-bearing potential or must have evidence of non-child-bearing potential by fulfilling one of the following criteria at screening:\r\n* Post-menopausal defined as:\r\n** Aged more than  years and amenorrheic for at least  months following cessation of all exogenous hormonal treatments\r\n** Estradiol, follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels in post-menopausal range while receiving gonadotrophin releasing hormone (LHRH) analogues for medical castration in patients with breast cancer\r\n* Documentation of irreversible surgical sterilization by hysterectomy, bilateral oophorectomy or bilateral salpingectomy but not tubal ligation
Women of childbearing potential enrolling on study must have a negative serum pregnancy test prior to registration.\r\n* Childbearing potential is defined as women who are not postmenopausal (defined as amenorrheic for >=  months following cessation of any exogenous hormonal treatments; luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels in the postmenopausal range for women under ; radiation-induced oophorectomy with last menses >  months prior; or chemotherapy-induced menopause with last menses >  months prior) or surgically sterile (bilateral oophorectomy or hysterectomy).
Male patients: willing to use adequate contraception (barrier or abstinence) while on treatment with study drug and for  months after finishing treatment\r\n* Female patients: willing to use adequate contraception (barrier or abstinence) at least  weeks before receiving any study medication, while on treatment with study drug, and for  months after finishing treatment\r\n* Female patients: must not be pregnant or breast-feeding; women of child-bearing potential must have a negative pregnancy test prior to start of dosing or must have evidence of non-child-bearing potential by fulfilling one of the following criteria at screening: \r\n** Post-menopausal defined as aged more than  years and amenorrheic for at least  months following cessation of all exogenous hormonal treatments\r\n** Women under  years are considered postmenopausal if they have been amenorrheic for  months or more following cessation of exogenous hormonal treatments and with luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels in the post-menopausal range for the institution\r\n** Documentation of irreversible surgical sterilization by hysterectomy, bilateral oophorectomy, or bilateral salpingectomy but not tubal ligation
Female patients: Must not be pregnant or breast-feeding; women of child-bearing potential must have a negative pregnancy test prior to start of dosing or must have evidence of non-child-bearing potential by fulfilling one of the following criteria at screening:\r\n* Post-menopausal defined as aged more than  years and amenorrheic for at least  months following cessation of all exogenous hormonal treatments\r\n* Women under  years are considered postmenopausal if they have been amenorrheic for  months or more following cessation of exogenous hormonal treatments and with luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels in the post-menopausal range for the institution\r\n* Documentation of irreversible surgical sterilization by hysterectomy, bilateral oophorectomy, or bilateral salpingectomy but not tubal ligation
Women of childbearing potential enrolling on study must have a negative serum pregnancy test prior to registration\r\n* Childbearing potential is defined as women who are not postmenopausal (defined as amenorrheic for >=  months following cessation of any exogenous hormonal treatments; luteinizing hormone [LH] and follicle stimulating hormone [FSH] levels in the postmenopausal range for women under ; radiation-induced oophorectomy with last menses >  months prior; or chemotherapy-induced menopause with last menses >  months prior) or surgically sterile (bilateral oophorectomy or hysterectomy)
Women of child-bearing potential and men must agree to use enhanced methods of contraception; all women are considered to be of childbearing potential unless they fulfill one of the following criteria at screening:\r\n* Post-menopausal defined as age >=  and amenorrheic for at least  months OR\r\n* Women age <  if they have been amenorrheic for at least  months and have a serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) level in the postmenopausal range (per institutional standards)\r\n* If women have documentation of irreversible surgical sterilization by hysterectomy, bilateral oophorectomy, or bilateral salpingectomy, or bilateral tubal ligation, they are considered post-menopausal
Post-menopausal defined as age more than  years and amenorrheic for at least  months following cessation of all exogenous hormonal treatments.
Women under  years old would be considered postmenopausal if they have been amenorrheic for  months or more, following cessation of exogenous hormonal treatments, and with luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels in the post-menopausal range for the laboratory.
Pregnant women are excluded from this study because olaparib has the potential for teratogenic or abortifacient effects. Women must either be post-menopausal or must have a negative pregnancy test (urine or serum) =<  days prior to enrollment and confirmed on day  of cycle  of study therapy\r\nPostmenopausal is defined as:\r\n* Amenorrheic for  year or more following cessation of exogenous hormonal treatments\r\n* Luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels in the post-menopausal range for women under  years of age\r\n* Radiation-induced oophorectomy with last menses >  year ago\r\n* Chemotherapy-induced menopause with > -year interval since last menses\r\n* Surgical sterilization (bilateral oophorectomy or hysterectomy)
Evidence of post-menopausal status OR negative urinary or serum pregnancy test for female pre-menopausal patients; women will be considered post-menopausal if they have been amenorrheic for  months without an alternative medical cause; the following age-specific requirements apply: \r\n* Women <  years of age would be considered post-menopausal if they have been amenorrheic for  months or more following cessation of exogenous hormonal treatments and if they have luteinizing hormone and follicle-stimulating hormone levels in the post-menopausal range for the institution or underwent surgical sterilization (bilateral oophorectomy, or hysterectomy)\r\n* Women ?  years of age would be considered post-menopausal if they have been amenorrheic for  months or more following cessation of all exogenous hormonal treatments, had radiation-induced menopause with last menses >  year ago, had chemotherapy-induced menopause with last menses >  year ago, or underwent surgical sterilization (bilateral oophorectomy, bilateral salpingectomy or hysterectomy).
Female subjects must be postmenopausal or there must be evidence of non-childbearing status for women of childbearing potential: negative urine or serum pregnancy test within  days of study treatment and confirmed prior to treatment on day . Postmenopausal is defined as:\r\n* Amenorrheic for  year or more following cessation of exogenous hormonal treatments.\r\n* Luteinizing hormone (LH) and Follicle stimulating hormone (FSH) levels in the post-menopausal range for women under .\r\n* Radiation-induced oophorectomy with last menses >  year ago.\r\n* Chemotherapy-induced menopause with >  year interval since last menses.\r\n* Surgical sterilization (bilateral oophorectomy or hysterectomy).
Negative pregnancy test done =<  days (or per institutional policy) prior to treatment, for women of childbearing potential only. Female must use highly effective contraceptive measures, and must have a negative pregnancy test or must have evidence of non-child-bearing potential by fulfilling one of the following criteria at screening:\r\n* Post-menopausal defined as aged more than  years and amenorrheic for at least  months following cessation of all exogenous hormonal treatments\r\n* Women under  years old would be considered postmenopausal if they have been amenorrheic for  months or more following cessation of exogenous hormonal treatments and with luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels in the post-menopausal range for the institution\r\n* Documentation of irreversible surgical sterilization by hysterectomy, bilateral oophorectomy or bilateral salpingectomy but not tubal ligation
Evidence of post-menopausal status or negative urinary or serum pregnancy test for female pre-menopausal subjects. Women will be considered post-menopausal if they have been amenorrheic for  months without an alternative medical cause. The following age-specific requirements apply: Women <  years of age would be considered post-menopausal if they have been amenorrheic for  months or more following cessation of exogenous hormonal treatments and if they have luteinizing hormone and follicle-stimulating hormone levels in the post-menopausal range for the institution or underwent surgical sterilization (bilateral oophorectomy or hysterectomy).
Women >=  years of age would be considered post-menopausal if they have been amenorrheic for  months or more following cessation of all exogenous hormonal treatments, had radiation-induced menopause with last menses >  year ago, had chemotherapy-induced menopause with last menses >  year ago, or underwent surgical sterilization (bilateral oophorectomy, bilateral salpingectomy or hysterectomy).
Post-menopausal defined as aged more than  years and amenorrhoeic for at least  months following cessation of all exogenous hormonal treatments
Women under  years old would be considered postmenopausal if they have been amenorrheic for  months or more following cessation of exogenous hormonal treatments and with luteinizing hormone and follicle-stimulating hormone levels in the post-menopausal range for the institution
Women will be considered post-menopausal if they have been amenorrheic for the past  months without an alternative medical cause. The following age-specific requirements must also apply: \r\n* Women <  years old: they would be considered post-menopausal if they have been amenorrheic for the past  months or more following cessation of exogenous hormonal treatments. The levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) must also be in the post-menopausal range (as per the institution). \r\n* Women >=  years old: they would be consider post-menopausal if they have been amenorrheic for the past  months or more following cessation of all exogenous hormonal treatments, or have had radiation-induced oophorectomy with the last menses > \r\nyear ago, or have had chemotherapy-induced menopause with >  year interval since last menses, or have had surgical sterilization by either bilateral oophorectomy or hysterectomy
Evidence of post-menopausal status or negative urinary or serum pregnancy test for female pre-menopausal patients; women will be considered post-menopausal if they have been amenorrheic for  months without an alternative medical cause; the following age-specific requirements apply:\r\n* Women <  years of age would be considered post-menopausal if they have been amenorrhea for  months or more following cessation of exogenous hormonal treatments and if they have luteinizing hormone and follicle-stimulating hormone levels in the post-menopausal range for the institution or underwent surgical sterilization (bilateral oophorectomy or hysterectomy)\r\n* Women >=  years of age would be considered post-menopausal if they have been amenorrheic for  months or more following cessation of all exogenous hormonal treatments, had radiation-induced oophorectomy with last menses >  year ago, had chemotherapy-induced menopause with >  year interval since last menses, or underwent surgical sterilization (bilateral oophorectomy or hysterectomy)
Female subjects must either be of non-reproductive potential (i.e., post-menopausal as described below) OR history of surgical sterilization (hysterectomy, bilateral tubal ligation, or bilateral oophorectomy) or must have a negative serum pregnancy test upon study entry\r\n* Women <  years of age would be considered post-menopausal if they have been amenorrheic for  months or more following cessation of exogenous hormonal treatments and if they have luteinizing hormone and follicle-stimulating hormone levels in the post-menopausal range for the institution\r\n* Women >=  years of age would be considered post-menopausal if they have been amenorrheic for  months or more following cessation of all exogenous hormonal treatments, had radiation-induced menopause with last menses >  year ago, or had chemotherapy-induced menopause with last menses >  year ago
Evidence of post-menopausal status or negative urinary or serum pregnancy test for female pre-menopausal patients; women will be considered post-menopausal if they have been amenorrheic for  months without an alternative medical cause; the following age-specific requirements apply:\r\n* Women <  years of age would be considered post-menopausal if they have been amenorrheic for  months or more following cessation of exogenous hormonal treatments and if they have luteinizing hormone and follicle-stimulating hormone levels in the post-menopausal range for the institution or underwent surgical sterilization (bilateral oophorectomy or hysterectomy)\r\n* Women >=  years of age would be considered post-menopausal if they have been amenorrheic for  months or more following cessation of all exogenous hormonal treatments, had radiation-induced menopause with last menses >  year ago, had chemotherapy-induced menopause with last menses >  year ago, or underwent surgical sterilization (bilateral oophorectomy, bilateral salpingectomy or hysterectomy; subject is willing and able to comply with the protocol for the duration of the study including undergoing treatment and scheduled visits and examinations including follow up
Evidence of post-menopausal status or negative urine or serum pregnancy test for female pre-menopausal subjects; women will be considered post-menopausal if they have been amenorrheic for  months without an alternative medical cause; the following age-specific requirements apply:\r\n* Women <  years of age would be considered post-menopausal if they have been amenorrheic for  months or more following cessation of exogenous hormonal treatments and if they have luteinizing hormone and follicle-stimulating hormone levels in the post-menopausal range for the institution or underwent surgical sterilization (bilateral oophorectomy or hysterectomy)\r\n* Women >=  years of age would be considered post-menopausal if they have been amenorrheic for  months or more following cessation of all exogenous hormonal treatments, had radiation-induced menopause with last menses >  year ago, had chemotherapy-induced menopause with last menses >  year ago, or underwent surgical sterilization (bilateral oophorectomy, bilateral salpingectomy, or hysterectomy)
Postmenopausal or evidence of non-childbearing status for women of childbearing potential: negative urine or serum pregnancy test within  days of study treatment. Postmenopausal is defined as: amenorrheic for  year or more following cessation of exogenous hormonal treatments; luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels in the postmenopausal range for women under ; radiation-induced oophorectomy with last menses >  year ago; chemotherapy-induced menopause with >  year interval since last menses; OR surgical sterilization (bilateral oophorectomy or hysterectomy)
The following age-specific requirements must also apply:\r\nWomen <  years old: they would be considered post-menopausal if they have been amenorrheic for the past  months or more following cessation of exogenous hormonal treatments; the levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) must also be in the post-menopausal range (as per the institution); women >=  years old: they would be considered post-menopausal if they have been amenorrheic for the past  months or more following cessation of all exogenous hormonal treatments, or have had radiation-induced oophorectomy with the last menses >  year ago, or have had chemotherapy-induced menopause with >  year interval since last menses, or have had surgical sterilization by either bilateral oophorectomy or hysterectomy
Post-menopausal: defined as more than  years-of-age and amenorrhoeic for at least  months following cessation of all exogenous hormonal treatments
Evidence of post-menopausal status or negative urinary or serum pregnancy test for female pre-menopausal patients; women will be considered post-menopausal if they have been amenorrheic for  months without an alternative medical cause; the following age-specific requirements apply:\r\n* Women <  years of age would be considered post-menopausal if they have been amenorrheic for  months or more following cessation of exogenous hormonal treatments and if they have luteinizing hormone and follicle-stimulating hormone levels in the post-menopausal range for the institution or underwent surgical sterilization (bilateral oophorectomy or hysterectomy)\r\n* Women >=  years of age would be considered post-menopausal if they have been amenorrheic for  months or more following cessation of all exogenous hormonal treatments, had radiation-induced menopause with last menses >  year ago, had chemotherapy-induced menopause with last menses >  year ago, or underwent surgical sterilization (bilateral oophorectomy, bilateral salpingectomy or hysterectomy; subject is willing and able to comply with the protocol for the duration of the study including undergoing treatment and scheduled visits and examinations including follow up
PHASE I: Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry, for the duration of study participation and for  days (both male and female) following last dose of study drug; should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately; fertile females of childbearing potential are defined as women physically capable of becoming pregnant unless the female patient cannot have children because of surgery or other medical reasons (effective tubal ligation, ovaries or the uterus removed, or are post-menopausal); post-menopausal is defined as:\r\n* Amenorrheic for  year or more following cessation of exogenous hormonal treatments,\r\n* Luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels in the post menopausal range for women under ,\r\n* Radiation-induced oophorectomy with last menses >  year ago,\r\n* Chemotherapy-induced menopause with >  year interval since last menses, or\r\n* Surgical sterilization (bilateral oophorectomy or hysterectomy)
PHASE II SCLC: Women of child-bearing potential and men must agree to use highly effective contraception (hormonal or barrier method of birth control; abstinence) prior to study entry, for the duration of study participation and for  days (both male and female) following last dose of study drug; should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately; fertile females of childbearing potential are defined as women physically capable of becoming pregnant unless the female patient cannot have children because of surgery or other medical reasons (effective tubal ligation, ovaries or the uterus removed, or are post-menopausal); post-menopausal is defined as:\r\n* Amenorrheic for  year or more following cessation of exogenous hormonal treatments,\r\n* LH and FSH levels in the post menopausal range for women under ,\r\n* Radiation-induced oophorectomy with last menses >  year ago,\r\n* Chemotherapy-induced menopause with >  year interval since last menses, or\r\n* Surgical sterilization (bilateral oophorectomy or hysterectomy)
UROTHELIAL CARCINOMA EXPANSION COHORT: Women of childbearing potential and men must agree to use highly effective contraception (hormonal or barrier method of birth control; abstinence) prior to study entry, for the duration of study participation and for  days (both male and female) following last dose of study drug; should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately; fertile females of childbearing potential are defined as women physically capable of becoming pregnant unless the female patient cannot have children because of surgery or other medical reasons (effective tubal ligation, ovaries or the uterus removed, or are post-menopausal); post-menopausal is defined as:\r\n* Amenorrheic for  year or more following cessation of exogenous hormonal treatments,\r\n* LH and FSH levels in the post menopausal range for women under ,\r\n* Radiation-induced oophorectomy with last menses >  year ago,\r\n* Chemotherapy-induced menopause with >  year interval since last menses, or\r\n* Surgical sterilization (bilateral oophorectomy or hysterectomy)
Females should not be breast feeding and must have a negative pregnancy test prior to start of dosing if of child-bearing potential or must have evidence of non-child-bearing potential by fulfilling one of the following criteria at screening:\r\n* Post-menopausal defined as aged more than  years and amenorrheic for at least  months following cessation of all exogenous hormonal treatments \r\n* Women under  years old would be consider postmenopausal if they have been amenorrheic for  months or more following cessation of exogenous hormonal treatments and with luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels in the post-menopausal range for the institution\r\n* Documentation of irreversible surgical sterilization by hysterectomy, bilateral oophorectomy or bilateral salpingectomy but not tubal ligation
Evidence of post-menopausal status or negative urinary or serum pregnancy test for female pre-menopausal patients; women will be considered post-menopausal if they have been amenorrheic for  months without an alternative medical cause; the following age-specific requirements apply: \r\n* Women <  years of age would be considered post-menopausal if they have been amenorrheic for  months or more following cessation of exogenous hormonal treatments and if they have luteinizing hormone and follicle-stimulating hormone levels in the post-menopausal range for the institution or underwent surgical sterilization (bilateral oophorectomy or hysterectomy)\r\n* Women >=  years of age would be considered post-menopausal if they have been amenorrheic for  months or more following cessation of all exogenous hormonal treatments, had radiation-induced menopause with last menses >  year ago, had chemotherapy-induced menopause with last menses >  year ago, or underwent surgical sterilization (bilateral oophorectomy, bilateral salpingectomy or hysterectomy)
Female subjects must either be of non-reproductive potential or must have a negative serum pregnancy test within  days prior to registration on study; evidence of post-menopausal status or negative urinary or serum pregnancy test for female pre-menopausal patients; women will be considered post-menopausal if they have been amenorrheic for  months without an alternative medical cause; the following age-specific requirements apply:\r\n* Women <  years of age would be considered post-menopausal if they have been amenorrheic for  months or more following cessation of exogenous hormonal treatments and if they have luteinizing hormone and follicle-stimulating hormone levels in the post-menopausal range for the institution or underwent surgical sterilization (bilateral oophorectomy or hysterectomy)\r\n* Women >=  years of age would be considered post-menopausal if they have been amenorrheic for  months or more following cessation of all exogenous hormonal treatments, had radiation induced menopause with last menses >  year ago, had chemotherapy-induced menopause with last menses >  year ago, or underwent surgical sterilization (bilateral oophorectomy, bilateral salpingectomy or hysterectomy)
Female patients are considered to be of childbearing potential unless:\r\n* They are post-menopausal (defined as older than  years and amenorrheic for at least  months following cessation of all exogenous hormonal treatments)\r\n* There is documentation of irreversible surgical sterilization by hysterectomy, bilateral oophorectomy or bilateral salpingectomy (but not tubal ligation), or\r\n* They are  years or younger but have been amenorrheic for at least  months following the cessation of exogenous hormonal treatments, and have serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels in the postmenopausal range for the institution\r\n** Female patients who are of childbearing potential must agree to use adequate contraceptive measures (as defined below) for the duration of study participation, and for  days after the final dose of study drug; cessation of birth control after this point should be discussed with a responsible physician; they also may not be breast feeding and must have a negative serum or urine pregnancy test within  hours prior to start of study treatment\r\n** Male patients who are sexually active with a female partner of childbearing potential must be either surgically sterilized or agree to use barrier contraception (i.e., condoms) for the duration of study participation, and for  days after the final dose of study drug; cessation of birth control after this point should be discussed with a responsible physician
Evidence of non-childbearing status for women of childbearing potential: negative urine or serum pregnancy test within  days of study treatment, confirmed prior to treatment on day ; postmenopausal is define as:\r\n* Amenorrheic for  year or more following cessation of exogenous hormonal treatments\r\n* Luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels in the post-menopausal range for women under \r\n* Radiation-induced oophorectomy with last menses >  year ago\r\n* Chemotherapy-induced menopause with >  year interval since last menses\r\n* Surgical sterilization (bilateral oophorectomy or hysterectomy)
Female subjects should be using highly effective contraceptive measures, and must have a negative pregnancy test and not be breast-feeding prior to start of dosing if of child- bearing potential or must have evidence of non-child-bearing potential by fulfilling one of the following criteria at screening:\r\n* Post-menopausal defined as aged more than  years and amenorrheic for at least  months following cessation of all exogenous hormonal treatments\r\n* Women under  years old would be consider postmenopausal if they have been amenorrheic for  months or more following cessation of exogenous hormonal treatments and with luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels in the post-menopausal range for the institution\r\n* Documentation of irreversible surgical sterilization by hysterectomy, bilateral oophorectomy or bilateral salpingectomy but not tubal ligation
Evidence of post-menopausal status or negative urinary or serum pregnancy test for pre-menopausal patients is required; women will be considered post-menopausal if they have been amenorrheic for  months without an alternative medical cause; the following age-specific requirements apply:\r\n* Women <  years of age would be considered post-menopausal if they have been amenorrheic for  months or more following cessation of exogenous hormonal treatments and if they have luteinizing hormone and follicle stimulating hormone levels in the post-menopausal range for the institution or underwent surgical sterilization (bilateral oophorectomy or hysterectomy)\r\n* Women >=  years of age would be considered post-menopausal if they have been amenorrheic for  months or more following cessation of all exogenous hormonal treatments, had radiation-induced oophorectomy with last menses >  year ago, had chemotherapy-induced menopause with > -year interval since last menses, or underwent surgical sterilization (bilateral oophorectomy, bilateral salpingectomy or hysterectomy)
Evidence of post-menopausal status or negative urinary or serum pregnancy test for female pre-menopausal patients; women will be considered post-menopausal if they have been amenorrheic for  months without an alternative medical cause; the following age-specific requirements apply:\r\n* Women <  years of age would be considered post-menopausal if they have been amenorrheic for  months or more following cessation of exogenous hormonal treatments and if they have luteinizing hormone and follicle-stimulating hormone levels in the post-menopausal range for the institution or underwent surgical sterilization (bilateral oophorectomy or hysterectomy)\r\n* Women >=  years of age would be considered post-menopausal if they have been amenorrheic for  months or more following cessation of all exogenous hormonal treatments, had radiation-induced menopause with last menses >  year ago, had chemotherapy-induced menopause with last menses >  year ago, or underwent surgical sterilization (bilateral oophorectomy, bilateral salpingectomy or hysterectomy)
Subjects must either be of non-reproductive potential (ie, post-menopausal by history; OR history of hysterectomy, OR history of bilateral tubal ligation, OR history of bilateral oophorectomy) or must have a negative serum or urine pregnancy test upon study entry; women will be considered post-menopausal if they have been amenorrheic for  months without an alternative medical cause; the following age-specific requirements apply:\r\n* Women <  years of age would be considered post-menopausal if they have been amenorrheic for  months or more following cessation of exogenous hormonal treatments and if they have luteinizing hormone and follicle-stimulating hormone levels in the post-menopausal range for the institution or underwent surgical sterilization (bilateral oophorectomy or hysterectomy)\r\n* Women >/=  years of age would be considered post-menopausal if they have been amenorrheic for  months or more following cessation of all exogenous hormonal treatments, had radiation-induced menopause with last menses >  year ago, had chemotherapy-induced menopause with last menses >  year ago, or underwent surgical sterilization (bilateral oophorectomy, bilateral salpingectomy or hysterectomy)
Postmenopausal or evidence of non-childbearing status for women of childbearing potential: negative urine or serum pregnancy test within  days and within  hours of study treatment and confirmed prior to receiving treatment on this study. Patients with positive results will be removed from the study. Postmenopausal is defined as: . amenorrheic for  year or more following cessation of exogenous hormonal treatments. . luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels in the postmenopausal range for women under . . radiation-induced oophorectomy with last menses >  year ago. . chemotherapy-induced menopause with > year interval since last menses. . surgical sterilization (bilateral oophorectomy or hysterectomy). . female patients must agree to use a highly effective birth control method while on study and for at least  month after your last dose of study drug(s).
For women of childbearing potential, a negative serum or urine pregnancy test within  days prior to step  registration; Note: women will be considered post-menopausal if they have been amenorrheic for  months without an alternative medical cause; the following age-specific requirements apply: \r\n* Women <  years of age would be considered post-menopausal if they have been amenorrheic for  months or more following cessation of exogenous hormonal treatments and if they have luteinizing hormone and follicle-stimulating hormone levels in the post-menopausal range for the institution or underwent surgical sterilization (bilateral oophorectomy or hysterectomy)\r\n* Women >=  years of age would be considered post-menopausal if they have been amenorrheic for  months or more following cessation of all exogenous hormonal treatments, had radiation-induced menopause with last menses >  year ago, had chemotherapy-induced menopause with last menses >  year ago, or underwent surgical sterilization (bilateral oophorectomy, bilateral salpingectomy or hysterectomy)
Women of child-bearing potential are expected to use highly effective contraception during the study and for  month after the last dose of study drug; postmenopausal or evidence of non-childbearing status for women of childbearing potential: negative urine or serum pregnancy test within  days of study treatment and confirmed prior to treatment on day ; postmenopausal is defined as:\r\n* Amenorrheic for  year or more following cessation of exogenous hormonal treatments\r\n* Luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels in the post-menopausal range for women under \r\n* Radiation-induced oophorectomy with last menses >  year ago\r\n* Chemotherapy-induced menopause with >  year interval since last menses\r\n* Surgical sterilization (bilateral oophorectomy or hysterectomy)
Postmenopausal or evidence of non-pregnant status for women of childbearing potential as confirmed by a negative urine or serum pregnancy test within  days prior to the start of therapy; postmenopausal status is defined as:\r\n* Age >=  years, or\r\n* Age <  with any one or more of the conditions below:\r\n** Amenorrheic for >=  year in the absence of chemotherapy and/or hormonal treatments,\r\n** Luteinizing hormone and/or follicle stimulating hormone and/or estradiol levels in the post-menopausal range,\r\n** Radiation-induced oophorectomy with last menses >  year ago,\r\n** Chemotherapy-induced menopause with >  year interval since last menses,\r\n** Surgical sterilization (bilateral oophorectomy or hysterectomy)
Evidence of non-childbearing status for women of childbearing potential, or postmenopausal status: negative urine or serum pregnancy test within  days of study treatment, confirmed prior to treatment on day ; postmenopausal is defined as:\r\n* Amenorrheic for  year or more following cessation of exogenous hormonal treatments\r\n* Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels in the post-menopausal range for women under \r\n* Radiation-induced oophorectomy with last menses >  year ago\r\n* Chemotherapy-induced menopause with >  year interval since last menses\r\n* Or surgical sterilization (bilateral oophorectomy or hysterectomy)
Female patients must be willing to use  forms of highly effective contraception (per institution standards) from the time of screening until  weeks after discontinuing study, must not be breast feeding and must have a negative pregnancy test prior to start of dosing if of child bearing potential or must have evidence of non-childbearing potential by fulfilling one of the following criteria at screening: () post-menopausal women, defined as either women aged more than  years and amenorrheic for at least  months following cessation of all exogenous hormonal treatments, or, () women under  years old who have been amenorrheic for at least  months following the cessation of exogenous hormonal treatments, and have serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels in the postmenopausal range for the institution; alternatively, women must have documentation of irreversible surgical sterilization by hysterectomy, bilateral oophorectomy or bilateral salpingectomy but not tubal ligation; male patients should either be surgically sterile or willing to use an effective barrier method of contraception during the study and for  weeks following the last dose of study treatment if sexually active with a female of childbearing potential; if not done previously, storage of sperm prior to receiving AZD will be advised to male patients with a desire to have children
Postmenopausal or evidence of non-childbearing status for women of childbearing potential: negative serum pregnancy test within  days of study treatment and confirmed prior to treatment on day .\r\n* Postmenopausal is defined as any one or more of the following:\r\n** Age >=  years.\r\n** Age <  and amenorrheic for  year or more in the absence of chemotherapy and/or hormonal treatment.\r\n** Luteinizing hormone (LH) and Follicle stimulating hormone (FSH) levels in the post menopausal range for women under .\r\n** Radiation-induced oophorectomy with last menses >  year ago.\r\n** Chemotherapy-induced menopause with >  year interval since last menses.\r\n** Surgical sterilisation (bilateral oophorectomy or hysterectomy).
Women who are breast feeding or pregnant\r\n* Men or women of reproductive potential who are not willing to employ effective birth control from screening to  days after the last dose of study drugs; the definition of adequate contraception will be based on the judgment of the principal investigator or a designated associate\r\nFor a female patient to be considered as not of child bearing potential, she should fulfill one of the following:\r\n* Post-menopausal women, defined as either women aged more than  years and amenorrhoeic for at least  months following cessation of all exogenous hormonal treatments, or, women under  years old who have been amenorrhoeic for at least  months following the cessation of exogenous hormonal treatments, and have serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels in the postmenopausal range for the institution Or\r\n* Have documentation of irreversible surgical sterilization by hysterectomy, bilateral oophorectomy or bilateral salpingectomy (but not tubal ligation)
Evidence of post-menopausal status or negative urinary or serum pregnancy test for female pre-menopausal patients; women will be considered post-menopausal if they have been amenorrheic for  months without an alternative medical cause; the following age-specific requirements apply:\r\n* Women <  years of age would be considered post-menopausal if they have been amenorrheic for  months or more following cessation of exogenous hormonal treatments and if they have luteinizing hormone and follicle-stimulating hormone levels in the post-menopausal range for the institution or underwent surgical sterilization (bilateral oophorectomy or hysterectomy)\r\n* Women >=  years of age would be considered post-menopausal if they have been amenorrheic for  months or more following cessation of all exogenous hormonal treatments, had radiation-induced menopause with last menses >  year ago, had chemotherapy-induced menopause with last menses >  year ago, or underwent surgical sterilization (bilateral oophorectomy, bilateral salpingectomy or hysterectomy)\r\n* A positive serum pregnancy test must be confirmed by a pelvic ultrasound (US) since some non-seminomatous germ cell tumors (NSGCT) may secrete beta-hCG and cause a false positive pregnancy; a pelvic US does not need to be repeated with each cycle unless the treating physician thinks it is necessary to do so
Women of non-child bearing potential must be:\r\n* Women more than  years must be post-menopausal for at least  months following the end of all exogenous hormonal treatments OR\r\n* Women under  years must be postmenopausal for at least  months following the end of exogenous hormonal treatments and with LH and FSH levels in the post-menopausal range for the institution OR\r\n* Documentation of irreversible surgical sterilization by hysterectomy, bilateral oophorectomy or bilateral salpingectomy but not tubal ligation
Women of childbearing potential must have a negative urine or serum pregnancy test within  days of initial dose of olaparib and temozolomide, confirmed prior to treatment on day ; postmenopausal is defined as:\r\n* Amenorrheic for  year or more following cessation of exogenous hormonal treatments\r\n* Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels in the postmenopausal range for women under \r\n* Radiation-induced oophorectomy with last menses >  year ago\r\n* Chemotherapy-induced menopause with >  year interval since last menses, or surgical sterilization (bilateral oophorectomy or hysterectomy)
Evidence of post-menopausal status or negative urinary or serum pregnancy test for female pre-menopausal patients; women will be considered post-menopausal if they have been amenorrheic for  months without an alternative medical cause; the following age-specific requirements apply: \r\n* Women <  years of age would be considered post-menopausal if they have been amenorrheic for  months or more following cessation of exogenous hormonal treatments and if they have luteinizing hormone and follicle-stimulating hormone levels in the post-menopausal range for the institution or underwent surgical sterilization (bilateral oophorectomy or hysterectomy)\r\n* Women >=  years of age would be considered post-menopausal if they have been amenorrheic for  months or more following cessation of all exogenous hormonal treatments, had radiation-induced menopause with last menses >  year ago, had chemotherapy-induced menopause with last menses >  year ago, or underwent surgical sterilization (bilateral oophorectomy, bilateral salpingectomy or hysterectomy)
Female patients must be willing to use  forms of highly effective contraception (per institution standards) from the time of screening until four weeks after discontinuing study, must not be breast feeding, and must have a negative pregnancy test prior to start of dosing if of child bearing potential or must have evidence of non-childbearing potential by fulfilling one of the following criteria at screening: () post-menopausal women, defined as either women aged more than  years and amenorrheic for at least  months following cessation of all exogenous hormonal treatments, or () women under  years old who have been amenorrheic for at least  months following the cessation of exogenous hormonal treatments, and have serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels in the postmenopausal range for the institution; alternatively, women must have documentation of irreversible surgical sterilization by hysterectomy, bilateral oophorectomy or bilateral salpingectomy but not tubal ligation; male patients should either be surgically sterile or willing to use an effective barrier method of contraception during the study and for  weeks following the last dose of study treatment if sexually active with a female of childbearing potential; if not done previously, storage of sperm prior to receiving AZD will be advised to male patients with a desire to have children