Ability to understand and the willingness to sign a written informed consent Patients must have the ability to understand and the willingness to sign a written informed consent prior to registration on study Patients must have the ability to understand and the willingness to sign a written informed consent prior to registration on study Patient has the ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent. Must have the ability to understand, and the willingness to sign, a written informed consent. Patients must have the ability to understand and the willingness to sign a written informed consent prior to registration on study Patients must have the ability to understand and the willingness to sign a written informed consent prior to registration Ability to understand and the willingness to sign a written informed consent Patients must have the ability to understand and the willingness to sign a written informed consent prior to registration on study Patients must have the ability to understand and the willingness to sign a written informed consent; all patients must have signed, witnessed informed consent prior to registration All patients must have the ability to understand and the willingness to sign an informed consent Patients must have the ability to understand and the willingness to sign a written informed consent prior to registration on study Patients must have the ability to understand and the willingness to sign a written informed consent prior to registration on study Patient has the ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Ability to understand and willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Ability to understand and willingness to sign a written informed consent All subjects must have the ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent. INCLUSION - ENROLLMENT: Ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent All research participants must have the ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Ability to understand and willingness to sign a written informed consent (I-SPY TRIAL Screening Consent) Ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Patients must have the ability to understand and the willingness to sign a written informed consent prior to registration on study All patients or legally responsible parent or guardian must have the ability to understand and willingness to sign a written informed consent. Ability to understand English language and the willingness to sign a written informed consent. Ability to understand and the willingness to sign a written informed consent Patients must have the ability to understand and the willingness to sign a written informed consent prior to registration on study Ability to understand and the willingness to sign a written informed consent Patients must have the ability to understand and the willingness to sign a written informed consent prior to registration on study Ability to understand and the willingness to sign a written informed consent The ability to understand and sign informed consent Ability to understand and the willingness to sign a written informed consent Patients must have the ability to understand and the willingness to sign a written informed consent prior to registration on study All subjects must have the ability to understand and the willingness to sign a written informed consent All subjects must have the ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Ability to understand and willingness to sign a written consent Ability to understand and the willingness to sign a written informed consent or have parental consent Ability to understand and the willingness to sign a written informed consent Patients must have the ability to understand and the willingness to sign a written informed consent prior to registration on study Ability to understand and the willingness to sign a written informed consent Ability of subject to understand and the willingness to sign written informed consent for study participation. Patients have the ability and willingness to sign written informed consent Patients must have the ability to understand and the willingness to sign a written informed consent prior to registration on study Patients must have the ability to understand and the willingness to sign a written informed consent prior to registration on study Patients must have the ability to understand and the willingness to sign a written informed consent prior to registration on study Ability to understand and the willingness to sign a written informed consent Ability to understand and willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Ability to understand and willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent All subjects must have the ability to understand and the willingness to sign a written informed consent All subjects must have the ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent All subjects must have the ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent All subjects must have the ability to understand and the willingness to sign a written informed consent Ability to understand, and willingness to sign, the written informed consent All research participants must have the ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Ability to understand and sign informed consent All patients must have the ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Subjects must have the ability to understand and the willingness to sign a written informed consent; informed consent must be obtained prior to registration on the study Ability to understand and willingness to give informed consent Ability to understand and the willingness to sign a written informed consent Ability to understand and sign a written informed consent Ability to understand and the willingness to sign a written protocol specific informed consent for tissue harvest or a parental/guardian informed consent and pediatric assent when appropriate. All subjects must have the ability to understand and the willingness to sign a written informed consent Ability to understand, and willingness to sign, the written informed consent Ability to understand AND willingness to sign a written informed consent Patients must have the ability to understand and the willingness to sign a written informed consent prior to registration on study Ability to understand and willingness to sign written informed consent Ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent All subjects must have the ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Ability to understand and willingness to sign an informed written consent Patients must have the ability to understand and the willingness to sign a written consent prior to registration in the study DOSE ESCALATION COHORT: Ability to understand and the willingness to sign a written informed consent DOSE EXPANSION COHORT: Ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Ability and willingness to sign informed consent prior to any study procedure All subjects must have the ability to understand and the willingness to sign a written informed consent All subjects must have the ability to understand and the willingness to sign a written informed consent All subjects must have the ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent All subjects must have the ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent All subjects must have the ability to understand and the willingness to sign a written informed consent Patients must have the ability to understand and to sign written informed consent All subjects must have the ability to understand and the willingness to sign a written informed consent Patients have ability and willingness to sign written informed consent Patient must exhibit the ability to understand and willingness to sign a written informed consent regarding the study and alternative treatments Ability to understand and the willingness to sign a written informed consent (ICF) Ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Ability to understand and sign a written informed consent for participation in the trial Patients must have the ability to understand and the willingness to sign a written informed consent prior to registration on study Ability to understand and the willingness to sign a written informed consent Patients must have the ability to understand and the willingness to sign a written informed consent prior to registration on study Ability to understand and the willingness to sign a written informed consent Patients must have the ability to understand and the willingness to sign a written informed consent prior to registration on study Patients must have the ability to understand and the willingness to sign a written informed consent prior to registration on study Patients must have the ability to understand and the willingness to sign a written informed consent prior to registration on study Ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent All subjects must have the ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Ability to understand and willingness to sign a written informed consent Patients have ability and willingness to sign written informed consent All subjects must have the ability to understand and the willingness to sign a written informed consent Ability to understand and willingness to sign written informed consent Ability to understand and the willingness to sign written informed consent and assent documents Ability to understand and willingness to sign informed consent Ability to understand and the willingness to sign a written informed consent All patients must have the ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent The ability to understand and sign a written informed consent Ability to understand and the willingness to sign a written informed consent Ability to understand and willingness to sign a written informed consent Willingness to sign written informed consent to this study Able to understand and willingness to sign a written informed consent. Ability to understand and the willingness to sign a written informed consent Patients must have the ability to understand and the willingness to sign a written informed consent; a signed informed consent must be obtained prior to initiation of treatment All subjects must have the ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent All subjects must have the ability to understand and the willingness to sign a written informed consent; only lucid patients qualified to consent to neurosurgical procedure will be approached for participation in this study Ability to understand and the willingness to sign a written informed screening and treatment consent Ability to understand and willingness to sign a written informed consent Ability to understand and willingness to sign written informed consent Ability to understand and the willingness to sign a written informed consent Patients must have the ability to understand and the willingness to sign a written informed consent prior to registration on study Patients must have the ability to understand and the willingness to sign a written informed consent prior to registration on study Ability to understand and the willingness to sign a written informed consent Patient has the ability to understand and the willingness to sign a written informed consent All subjects must have the ability to understand and the willingness to sign a written informed consent All subjects must have the ability to understand and the willingness to sign a written informed consent Patients must have the ability to understand and the willingness to sign a written informed consent prior to registration in the study. Patient able to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Ability to understand and willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent; consents will be provided in English or Spanish Ability to understand and the willingness to sign a written informed consent Ability to understand and willingness to sign written informed consent Ability to understand and the willingness to sign a written informed consent All subjects must have the ability to understand and the willingness to sign a written informed consent Ability and willingness to understand and sign an informed consent All subjects must have the ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent All subjects must have the ability to understand and the willingness to sign a written informed consent All patients must have the ability and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent All subjects must have the ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent. Ability to understand and willingness to sign informed consent Ability to understand and willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent All subjects must have the ability to understand and the willingness to sign a written informed consent All subjects must have the ability to understand and the willingness to sign a written informed consent RECIPIENT: All subjects must have the ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Willingness and ability to sign a written informed consent (assent if applicable) All subjects must have the ability to understand and the willingness to sign a written informed consent Subjects must have the ability to understand and the willingness to sign a written informed consent prior to registration on study Ability and willingness to sign written informed consent Ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent All subjects must have the ability to understand and the willingness to sign a written informed consent Ability and willingness to understand and sign an informed consent Ability to understand and sign informed consent. Ability to understand and willingness to sign a written informed consent All subjects must have the ability to understand and the willingness to sign a written informed consent All subjects must have the ability to understand and the willingness to sign a written informed consent Ability to understand and willingness to sign informed consent Ability to understand the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent All subjects must have the ability to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent Patients must have the ability to understand and the willingness to sign a written informed consent prior to registration on study Ability to understand and the willingness to sign a written informed consent. INCLUSION CRITERIA - FOR NORMAL HEALTHY FEMALE COHORT: Ability of subject to understand and the willingness to sign a written informed consent Ability to understand and the willingness to sign a written informed consent; all patients must have signed, witnessed informed consent prior to registration Ability to understand and willingness to sign informed consent Ability to understand and the willingness to sign a written informed consent