Subjects should not be vaccinated with live attenuated vaccines within one month prior to starting tremelimumab treatment Vaccinated with live, attenuated vaccines within weeks of first dose of study drug Vaccinated with live, attenuated vaccines within weeks of first dose of study drug Patients should not be vaccinated with live attenuated vaccines within month of starting tremelimumab and durvalumab treatment; subjects, if enrolled, should not receive live vaccine during the study and days after the last dose of both drugs Vaccinated with live, attenuated vaccines within weeks of first dose of avelumab Vaccinated with live, attenuated vaccines within weeks of enrollment Vaccinated with live, attenuated vaccine within weeks or as recommended by the product manufacturer prior to the first dose, during treatment, or within days of the last dose of JNJ- Vaccinated with live, attenuated vaccines within weeks of enrollment Vaccinated with live, attenuated vaccines within weeks of first dose of study drug. Patients should not be vaccinated with live attenuated vaccines within month of starting pembrolizumab treatment Vaccinated with live, attenuated vaccine(s) within days prior to first dose of study drug Vaccinated with live, attenuated vaccine within weeks of first dose of study drug Vaccinated with live, attenuated vaccines within weeks of enrollment Vaccinated with live, attenuated vaccines within weeks of first dose of study drug Vaccinated with live, attenuated vaccines within weeks of first dose of study drug Vaccinated with live, attenuated vaccines within weeks of enrollment Vaccinated with live, attenuated vaccines within weeks of first dose of study drug Vaccinated with live, attenuated vaccines within weeks of enrollment Patients should not be vaccinated with live attenuated vaccines within days of starting durvalumab or tremelimumab treatment Vaccinated with live, attenuated vaccines within weeks of first dose of study drug Vaccinated with live, attenuated vaccines within weeks of randomization Vaccinated with live, attenuated vaccines within weeks of study entry Subjects should not be vaccinated with live attenuated vaccines within one month prior to starting tremelimumab treatment Vaccinated with live, attenuated vaccines within weeks of initiation of therapy Vaccinated with live, attenuated vaccines within weeks of first dose of study drug Vaccinated with live, attenuated vaccines within weeks of first dose of study drug Vaccinated with live, attenuated vaccines within weeks of first dose of study drug Patient has been vaccinated with live attenuated vaccines within weeks before study vaccination Vaccinated with live, attenuated vaccines within weeks of first dose of study drug Vaccinated with live, attenuated vaccines within weeks of study entry Vaccinated with any of the vaccines planned for administration in the trial within weeks of starting treatment on the study Vaccinated with live, attenuated vaccines within weeks of first dose of study drug Patients should not be vaccinated with live attenuated vaccines within month of starting tremelimumab and/or durvalumab (MEDI) treatment Vaccinated with live, attenuated vaccines within weeks of the first dose of study drug Vaccinated with live attenuated vaccines =< weeks from starting study drugs Subjects should not be vaccinated with live attenuated vaccines within one month prior to starting tremelimumab treatment Vaccinated with live, attenuated vaccines within weeks of study entry Subjects that have been vaccinated with live, attenuated vaccines within weeks of the first dose of study drug are not eligible Patient must not be vaccinated with live, attenuated vaccines within weeks of first dose of study drug Vaccinated with live attenuated vaccines within weeks of first dose of study drug Vaccinated with live, attenuated vaccines within weeks of first dose of study drug Patients should not be vaccinated with live attenuated vaccines within month of starting tremelimumab treatment Vaccinated with live, attenuated vaccines within weeks of first dose of study drug Vaccinated with live, attenuated vaccines within weeks of initiation of therapy Vaccinated with live, attenuated vaccines within weeks of enrollment Vaccinated with live, attenuated vaccines within weeks of first dose of study drug. Vaccinated with live, attenuated vaccines with weeks of first does of study drug Vaccinated with live, attenuated vaccines =< weeks prior to registration Vaccinated with live, attenuated vaccines within weeks of treatment Vaccinated with live, attenuated vaccines within weeks of starting ibrutinib Vaccinated with live, attenuated vaccines within weeks of first dose of study drug Vaccinated with live, attenuated vaccines within weeks of first dose of study drug EXCLUSION CRITERIA (PRIOR TO IBRUTINIB ADMINISTRATION): Vaccinated with live, attenuated vaccines within weeks of first dose of study drug Vaccinated with live, attenuated vaccines within four weeks of the first dose of study drug