Creatinine clearance (CrCl) >= mL/min Patients with severe renal impairment (creatinine clearance [CrCL] < mL/min) are not eligible; a calculated CrCl is acceptable CrCl ? mL/min Creatinine clearance (CrCl) =< mL/min CrCl (Creatinine Clearance) is >= ml/min (<= days prior to enrollment) Creatinine ? . x ULN or creatinine clearance (CrCl) ? mL/min Creatinine clearance (CrCl) or estimated glomerular filtration rate (eGFR) >= ml/min; CrCl will be calculated by Cockcroft-Gault method; eGFR will be calculated by either of the following well established formulas: modification of diet in renal disease (MDRD) or the chronic kidney disease (CKD)-epidemiology collaboration (EPI) (institutional standard) equations; if calculated CrCl/eGFR is < mL/min, patient will have a hr urine collection to measure CrCl; the measured CrCl must also be >= ml/min Renal: Creatinine clearance (CrCl) > ml/min (measured or calculated/estimated). Serum creatinine ?.x the ULN or creatinine clearance (CrCl) ? mL/min. Serum creatinine (Cr) =< . X ULN or creatinine clearance (CrCl) >= ml/min Serum creatinine =< . x ULN or creatinine clearance (CrCl) >= mL/min Creatinine clearance (CrCl) must be > mL/min Calculated creatinine clearance (CrCl) > mL/min Calculated or measured creatinine clearance (CrCl) > ml/min Creatinine clearance (CrCl) value of >= ml/min by MDRD study equation Serum creatinine =< . x ULN or creatinine clearance (CrCl) >= mL/min Creatinine clearance (CrCl) > mL/min Per MDACC Creatinine clearance guidelines, patients must have a Creatinine clearance > ml/min determined by hour collection or nomogram: CrCl male = ( - age) x (wt in kg)/serum Cr x CrCl female = . x (CrCl male) Serum creatinine normal for age or calculated creatinine clearance (CrCl) >= ml/min/. m^ DOSE ESCALATION COHORT: Serum creatinine ? . X ULN or creatinine clearance (CrCl) ? ml/min DOSE EXPANSION COHORT: Serum creatinine ? . X ULN or CrCl ? ml/min Renal function: CrCl < ml/min. Serum creatinine clearance (CrCl) >= ml/min Creatinine clearance (CrCL) (calculated creatinine clearance is permitted) > mL/min CrCL >= ml/min Calculated creatinine clearance (CrCl) > mL/min Creatinine =< x ULN or creatinine clearance (CrCl) > ml/min Patients deemed to have severe renal impairment should not be considered for this study; patients with creatinine clearance (CrCl) of < mL/min should be excluded Serum creatinine =< md/dL or estimated creatinine clearance (CrCl) > ml/min/body surface area (BSA) Calculated creatinine clearance (CrCL) of ? mL/min Creatinine clearance (CrCl) >= mL/min Creatinine clearance (CrCL) >= ml/min Creatinine =< . x ULN or creatinine clearance (CrCl) calculated CrCl >= mL/min/.m^ Creatinine =< x ULN or creatinine clearance (CrCl) > ml/min Calculated or measured creatinine clearance (CrCl) of ? mL/min Calculated creatinine clearance (CRCL) > mL/min Creatinine clearance (CrCl) > mL/min Patients with severe renal impairment (creatinine clearance [CrCl] < mL/min); a calculated CrCl is acceptable Previous inability to tolerate full-dose lenalidomide, adjusted to creatinine clearance (CrCl) according to Cockroft-Gault at the time of previous lenalidomide treatment ( mg day - every days if CrCl >= ml/min, mg lenalidomide days (d) - every days if CrCl < mL/min but >= mL/min, lenalidomide mg every hours (h) d- every days if CrCl < mL/min but not requiring dialysis, lenalidomide mg daily, day - every days if CrCl < mL/min and requiring dialysis Creatinine clearance (CrCl) < mL/min Serum creatinine < ULN OR calculated creatinine clearance (CrCl) of ? ml/min Serum creatinine < . x upper limit of normal (ULN) or serum creatinine clearance (CrCl)> ml/min (CrCl= Wt (kg) x (-age)*/ x Cr. level, *female x .) Serum creatinine < or calculated creatinine clearance (CrCl) >= mL/min Calculated or measured creatinine clearance (CrCl) >= mL/min Renal impairment at baseline as measured by serum creatinine clearance (CrCl) ? mL/min ? days prior to registration. A measured or estimated creatinine clearance (CrCl) ? mL/min/. m A calculated creatinine clearance (CrCl) that meets entry criteria for enrollment (ie, calculated CrCl either ? or < mL/min CrCl ? mL/min as measured by -hour urine Donor must have adequate renal function as defined by a minimum creatinine clearance (CrCl) value of > ml/min. Severe renal impairment: estimated creatinine clearance (CrCl) < ml/min, but not requiring dialysis Normal renal function: estimated CrCl ? ml/min MDRD calculated or measured CrCl of ? mL/min MDRD calculated or measured CrCl of ? mL/min Serum creatinine =< . x ULN or creatinine clearance (CrCl) >= mL/min CrCL ? mL/min Creatinine > . x ULN or creatinine clearance levels (CrCL) < mL/min Estimated creatinine clearance (CrCl) >= ml/min Creatinine clearance (CrCl) < ml/min Patients with impaired renal function creatinine clearance (CRCL) =< mL/min Creatinine =< x ULN or creatinine clearance (CrCl) > ml/min Measured or calculated creatinine clearance (CrCl; GFR can also be used in place of CrCl) >= mL/min