The participant has a primary brain tumor
Patients should only have had a biopsy of the primary tumor without an attempt at complete or partial resection; patients will still be eligible if excision was attempted or accomplished as long as adequate anatomic imaging (MRI for most primary tumor sites) was obtained prior to surgery
Primary spine tumor
The participant has a primary brain tumor
Tumor(s) involving the brain stem
Patients who have an intact unresected primary tumor should be considered for radical nephrectomy and primary resection prior to enrollment in the study; if the patient is not eligible for surgical resection, the primary tumor must be amenable to SBRT or request for applications (RFA); generally, this will be defined as a primary tumor <  cm in size or a primary lesion which can be treated to a dose of >=  Gy x  without excessive perceived risk of toxicity
HER-expressing tumor (primary tumor or metastasis) as assessed by local lab testing
HER-positive tumor (primary tumor or metastasis) as assessed by local (non-central) laboratory testing
Any known tumor outside of the brain
Any known tumor outside of the brain
Primary brain or spine tumor are eligible, including tumors with metastases, multiple lesions
Has a known history of a hematologic malignancy, primary brain tumor or sarcoma, or of another primary solid tumor, unless the patient has undergone potentially curative therapy with no evidence of that disease for five years
Patients will be eligible regardless of whether they have had prior nephrectomy or still have their primary tumor in-situ.
Simultaneous primary cancers or separate bilateral primary tumor sites
Patients with metastatic disease are allowed, if indication to remove primary tumor
Primary tumor not amenable to TORS
Prior treatment with radiotherapy or chemotherapy for a brain tumor, irrespective of the grade of the tumor
If a primary tumor is in place, it must be asymptomatic
Patients must have an extra-cranial primary tumor diagnosis
Primary brain tumor
The subject has a primary brain tumor
Primary tumor may be located anywhere in the pancreas
Patients must have a measurable primary tumor (undetectable NSCLC primary tumor is ineligible)
Patients must have an extra-cranial primary tumor diagnosis
Primary brain tumor
The subject has a primary brain tumor
Multifocal primary tumor
Uncontrolled tumor in the brain
Patients with primary tumor histology of lymphoma, leukemia, or germ cell tumor
Tumor location in the brain stem
Simultaneous primary cancers or separate bilateral primary tumor sites.
Uncontrolled tumor in the brain
If primary tumor has not been resected, it must be clinically stable
HER- negative tumor (primary tumor or metastatic lesion)
History of a hematologic malignancy, primary brain tumor or sarcoma, or of another primary solid tumor, unless the participant has undergone potentially curative therapy with no evidence of that disease for  years
Planned resection of primary tumor
The subject has a primary brain tumor
Patient must have had their primary tumor treated with surgery and/or radiation
Intact primary tumor (for Immune Response Cohort only)
Primary tumor resected
Primary brain tumor
Tumor involving brain stem
Participants who have had an incisional biopsy of the primary tumor or the primary tumor excised
The participant has a primary brain tumor
HER-positive as assessed by local laboratory on primary or metastatic tumor
T stage , , ; surgery of the primary tumor is limited to incisional or excisional biopsies (i.e., tonsillectomy) even without macroscopic disease left; positive resection margins and/or gross residual disease at the primary site are allowed; evaluation of primary tumor extent may require the use of a flexible fibroscope if deemed clinically necessary by the treating physician
Diagnosis of primary brain tumor
For subjects receiving adjuvant therapy only, subjects must have undergone complete resection of the primary tumor with clean surgical margins, or subjects must have undergone resection of the primary tumor and be scheduled for further treatment of the primary tumor with curative intent. Definitive treatment must be planned to be completed within approximately  months of randomization
Radiation to primary tumor prior to enrollment in this study
The subject has a primary brain tumor
HER-positive primary or metastatic tumor as assessed by central laboratory
HER-positive tumor (primary tumor or metastatic lesion) as confirmed by central\n             laboratory HER testing (immunohistochemistry and/or in-situ hybridization)
Primary tumor and any positive node(s)measurable in  dimensions
Uncontrolled tumor in the brain
Unknown primary tumor.
The patient has a primary brain tumor. Patients may have brain metastases from another primary site.
Radiation to primary tumor prior to enrollment in this study
HER-positive tumor (primary tumor or metastasis)
HER-positive as assessed by local laboratory on primary or metastatic tumor
Uncontrolled tumor in the brain
Systemic disease burden with metastatic tumor to the brain
Extremity or central axis (including craniofacial) primary tumor; localized or metastatic
Diagnosis of a primary brain tumor treated with at least one of the following:\r\n* Neurosurgical resection of the brain tumor\r\n* Cranial irradiation\r\n* Any chemotherapy to treat the brain tumor
Known malignant primary brain tumor
Diagnosed with one or more metastatic brain tumor(s)
Primary tumor stage T- at initial diagnosis
Histologically confirmed diagnosis of malignant primary brain tumor or known metastatic cancer with brain lesion presumed to be metastatic
Active metastatic cancer in addition to malignant primary brain tumor
Patient is a candidate for cerebral tumor resection with lesion suspected to be or previously biopsy proven to be a primary brain tumor.
Two adult patient groups will be eligible for inclusion in this study: \r\n* Group A: Patients where there is compelling evidence, based on the MRI and/or CT imaging, that a high-grade primary brain tumor is present; pathologic confirmation will occur with biopsy or surgery; patients whose tumor is felt to be inoperable and a biopsy is performed but no surgery; patients with a newly diagnosed primary malignant brain tumor (World Health Organization [WHO] grade III or IV) who will be receiving chemoradiation and who either did not undergo surgical resection or underwent incomplete resection with residual tumor >= . cm in greatest diameter by contrast MRI postoperatively\r\n* Group B: Patients with pathologically proven malignant brain tumor (WHO grade III or IV glial-based tumors) who have undergone chemoradiation and have MRI-documented possible recurrence/progression versus treatment effect (pseudoprogression) within  months from the time of completion of chemoradiation
Subjects with a presumed diagnosis of brain tumor (based on imaging) or a confirmed brain tumor (based on pathology) before or after any oncologic treatment (surgery/chemotherapy/radiation)
Biopsy or resection of the primary tumor within  days the first injection of [F]F-AraG
Previous diagnosis of a brain tumor; patients who are either undergoing active treatment for a brain tumor or who have completed treatment will be eligible for study enrollment (Cohort )
Patients undergoing a tumor resection at the University of Texas M. D. Anderson Cancer Center for a newly diagnosed primary or metastatic brain tumor located in or adjacent to motor brain areas
Subject has undergone primary tumor resection prior to arrival at St. Jude
If patients have a history of malignancy other than melanoma or malignant brain tumor they must be disease-free (excluding primary cancer for metastatic patients) for >=  years at the time of enrollment
Participants may have had prior therapy for the primary brain tumor, including surgery, radiotherapy or chemotherapy
a primary brain tumor that has been histologically confirmed
OR confirmed or suspected recurrent brain cancer or brain metastasis for which the primary tumor has been histologically confirmed,
Patients who have received previous treatment (chemotherapy or radiotherapy) for any brain tumor (primary or metastatic)
Patients with a new or recurrent, presumed or documented, diagnosis of primary or secondary brain tumor in or adjacent to eloquent brain areas (motor, supplementary motor area [SMA] and language) who are scheduled to undergo tumor resection
Radiotherapy of brain tumor within  months before enrollment
Have a primary liver tumor
Other chemotherapy or anti-tumor treatment for brain tumor (other than therapies required by the inclusion criteria of this protocol)