Patient has acute promyelocytic leukemia (APML) Patients with Down syndrome, acute promyelocytic leukemia, juvenile myelomonocytic leukemia, or bone marrow failure syndromes are not eligible Newly diagnosed with acute myelogenous leukemia (except acute promyelocytic leukemia) and has failed one or two prior standard induction attempts. Failure is defined as: Acute promyelocytic leukemia Diagnosis of acute promyelocytic leukemia (M classification) Subject has acute promyelocytic leukemia Participant has acute promyelocytic leukemia Subjects diagnosed with Acute Promyelocytic Leukemia. Acute Promyelocytic Leukemia Patients with a diagnosis of acute promyelocytic leukemia Acute promyelocytic leukemia Patients with acute promyelocytic leukemia Acute promyelocytic leukemia Diagnosis of acute promyelocytic leukemia Has a diagnosis of acute promyelocytic leukemia. Subjects with acute promyelocytic leukemia (M) AML is of the sub-type of acute promyelocytic leukemia Has acute promyelocytic leukemia (AML subtype M) Acute promyelocytic leukemia Acute promyelocytic leukemia Acute promyelocytic leukemia Subject has a diagnosis of acute promyelocytic leukemia Acute Promyelocytic Leukemia Patients with acute promyelocytic leukemia Acute promyelocytic leukemia (FAB M) Acute Promyelocytic Leukemia (AML subtype M). Subject has acute promyelocytic leukemia. Acute promyelocytic leukemia (FAB M classification) Acute promyelocytic leukemia Acute Promyelocytic Leukemia Diagnosis of acute promyelocytic leukemia Patients with acute promyelocytic leukemia are excluded Dose Escalation: Acute Promyelocytic Leukemia Have acute promyelocytic leukemia and the associated cytogenic translocation t:(/) Diagnosis of AML-M (or acute promyelocytic leukemia) Acute promyelocytic leukemia (AML with t[;][q;q] and variants) Diagnosis of acute promyelocytic leukemia Acute promyelocytic leukemia [t(;)] Patients with acute promyelocytic leukemia Diagnosis of AML-M (or acute promyelocytic leukemia) Acute promyelocytic leukemia [t(;)] or favorable cytogenetics, including t(;) or inv if known at the time of randomization. The patient must not have acute promyelocytic leukemia or t(;) observed by FISH Acute promyelocytic leukemia Subjects with a diagnosis of Acute Promyelocytic Leukemia Promyelocytic leukemia Patients with a diagnosis of acute promyelocytic leukemia (according to WHO classification ) Subjects with the diagnosis of acute promyelocytic leukemia (t[;]) All subtypes of Acute Myeloid leukemia (except for acute promyelocytic leukemia) Diagnosis of acute promyelocytic leukemia Patients with acute promyelocytic leukemia according to WHO definition. Acute promyelocytic leukemia or AML with a t(;) (q;q) cytogenetic abnormality or Bcr/Abl positive leukemia Acute promyelocytic leukemia Newly diagnosed patients with Acute promyelocytic leukemia [t(;)] or favorable cytogenetics, including t(;) or inv A diagnosis of acute promyelocytic (M) or acute megakaryocytic leukaemia (M). Acute promyelocytic leukemia. Documented/confirmed acute myelogenous leukemia (AML), except for acute promyelocytic leukemia Diagnosis of acute promyelocytic leukemia Diagnosis of acute promyelocytic leukemia Newly diagnosed patients with Acute promyelocytic leukemia [t(;)] or favorable cytogenetics, including t(;) or inv A diagnosis of acute promyelocytic leukemia (APML) Acute promyelocytic leukemia Patients with acute promyelocytic leukemia Patients with acute promyelocytic leukemia Acute promyelocytic leukemia Patients with a diagnosis of acute promyelocytic leukemia AML subtype M (promyelocytic leukemia) Acute promyelocytic leukemia. Diagnosis of acute promyelocytic leukemia Acute promyelocytic leukemia (M classification). Acute promyelocytic leukemia Primary or secondary AML (including erythroleukemia and eosinophilic leukemia, but excluding acute promyelocytic leukemia) Diagnosis of promyelocytic leukemia