Persistent proteinuria >= grade NCI-CTCAE v. (> . g/ hours [hrs], measured by urine protein:creatinine ratio on a random urine sample) Persistent proteinuria >= grade NCI-CTCAE v. (> . g/ hrs, measured by urine protein:creatinine ratio on a random urine sample) FOR ALL PHASES (Ib AND II): Proteinuria of >= Common Terminology Criteria for Adverse Events (CTCAE) grade as estimated by urine protein : creatinine ratio > . on a random urine sample Persistent proteinuria >= grade per NCI-CTCAE v. (> . g/ hours [hrs], measured by urine protein: creatinine ratio on a random urine sample) Persistent proteinuria >= grade NCI-CTCAE version (v) . (> . g/ hours [hrs], measured by urine protein: creatinine ratio on a random urine sample) Proteinuria of CTCAE grade or higher (> . g/ h, measured by urine protein: creatinine ratio on a random urine sample) REGORAFENIB EXCLUSION CRITERIA: Persistent proteinuria >= grade (> . g/ hours [hrs], measured by urine protein:creatinine ratio on a random urine sample) Proteinuria =< grade (ie, =< + [ mg/dL] using a random urine sample or < . gm using a -hour sample)\r\n* Note: if urine sample indicates >= grade proteinuria (ie, + [ mg/dL]), a -hour urine sample must be collected and tested; urine protein in the -hour sample must be < . gm/ hours Persistent proteinuria >= grade NCI-CTCAE v. (> . g/ hrs, measured by urine protein:creatinine ratio on a random urine sample) Proteinuria =< + ( mg/dL) using a random urine sample or < . gm using a -hour sample; Note: If urine sample indicates >= + [ mg/dL]), a -hour urine sample must be collected and tested; urine protein in the -hour sample must be < . gm/ hours Proteinuria of CTCAE grade or higher (estimated by urine protein: creatinine ratio >= . on a random urine sample); patients who recently (i.e., at least days prior to registration) discontinued an anti-angiogenic therapy which caused proteinuria (ie, grade (> to > g of protein or -. g/ hours [h]) or grade proteinuria (> of protein or > . g/ h) are not eligible for enrollment until proteinuria improves to < g of protein per h Proteinuria >= grade (> . g/ hours, measured by urine protein: creatinine ratio on a random urine sample) Persistent proteinuria ? Grade NCI-CTCAE v. (> . g/ hrs, measured by urine protein: creatinine ratio on a random urine sample). Persistent proteinuria >= grade NCI-CTCAE v. (> . g/ hrs, measured by urine protein:creatinine ratio on a random urine sample) Persistent proteinuria grade or higher measured by urine protein:creatinine ratio on a urine sample or during -hour assessment Persistent proteinuria >= grade NCI-CTCAE v. (> . g/ hours [hrs], measured by urine protein:creatinine ratio on a random urine sample) Persistent proteinuria ? Grade NCI CTCAE v. as defined as > . g/ hours, measured by urine protein: creatinine ratio on a random urine sample. Persistent proteinuria >= grade National Cancer Institute (NCI)-Common Terminology Criteria for Adverse Events (CTCAE) version (v) . (> . g/ hours [hrs], measured by urine protein: creatinine ratio on a random urine sample) Patients with a history of kidney disease or persistent proteinuria must have < grade proteinuria per NCI CTCAE v. at screening; if a patient has a history of kidney disease or persistent proteinuria, a urine protein test will be performed on a random urine sample; if the result is normal then no additional testing is required; if the result is abnormal, a hour urine will be collected to determine if proteinuria is < grade Patients with a history of kidney disease or persistent proteinuria must have < grade proteinuria per NCI CTCAE v. at screening; if a patient has a history of kidney disease or persistent proteinuria, a urine protein test will be performed on a random urine sample; if the result is normal then no additional testing is required; if the result is abnormal, a hour urine will be collected to determine if proteinuria is < grade Patients with a history of kidney disease or persistent proteinuria must have < grade proteinuria per NCI CTCAE v . at screening; if a patient has a history of kidney disease or persistent proteinuria, a urine protein test will be performed on a random urine sample; if the result is normal then no additional testing is required; if the result is abnormal, a hour urine will be collected to determine if proteinuria is < grade