Creatinine clearance of > ml/min; creatinine clearance may be measured or calculated; if calculating, creatinine clearance, use the Cockroft-Gault formula =< weeks prior to randomization Serum creatinine ? . mg/dL or creatinine clearance ? mL/min measured or calculated by Cockroft Gault equation. Creatinine =< . mg/dl or creatinine clearance >= cc/min (can be calculated by hour urine or by the Cockroft-Gault formula) Calculated creatinine clearance using cockroft Gault formula >/= mL/min (see Appendix ) Adequate renal function as demonstrated by serum creatinine ?. x ULN or creatinine clearance> mL/min as calculated by the Cockroft and Gault formula Serum creatinine =< . x institution's upper limit of normal (ULN), or creatinine clearance >= ml/min (according to Cockroft-Gault formula, or local institutional standard method) Calculated creatinine clearance (by Cockroft-Gault) >= mL/min or serum creatinine below g/dL Renal: serum creatinine ?. x ULN or creatinine clearance (CrCl) ? mL/min as calculated by the Cockroft-Gault method Acceptable renal function, as specified below:: Creatinine clearance (CrCl) calculated by Cockroft-Gault formula of ? mL/min. Creatinine clearance (as calculated by Cockroft Gault equation >= mL/min Creatinine clearance >= ml/min determined by -hour collection or estimated by the Cockroft-Gault formula Serum creatinine =< . x ULN or calculated creatinine clearance >= ml/min (by Cockroft-Gault formula) Creatinine clearance (CrCl) >= ml/min (Cockroft-Gault equation) Serum creatinine =< . x ULN or serum creatinine > . x ULN if calculated creatinine clearance (CrCl) is >= mL/min using the Cockroft-Gault equation Creatinine clearance > mls/min (calculated with Cockroft-Gault formula); Participant must have adequate renal function as demonstrated by a creatinine >= mL/min; calculated by the Cockroft Gault formula or measured by hours urine collection. Serum creatinine =< . X institutional upper limit of normal or creatinine clearance >= mL/min (according to the Cockroft and Gault equation) STUDY TREATMENT: Creatinine clearance of ml/min or greater as measured by the Cockroft-Gault formula creatinine clearance ? mL/min (Cockroft & Gault formula); Serum creatinine > . x upper limit of normal (ULN) or creatinine clearance < mL/min (measured or calculated by Cockroft-Gault formula) Creatinine clearance (Cockroft-Gault calculated or -hour urine) >= mL/min Creatinine clearance < cc/min measured or calculated by Cockroft-Gault equation Creatinine clearance (CrCl) >= mL/min calculated by the Cockroft-Gault Creatinine clearance (calculated creatinine clearance by Cockroft-Gault using adjusted body weight if actual body weight is % greater than ideal is permitted) should be > ml/min Creatinine clearance >= mL/min (calculated using the Cockroft-Gault formula or measured with hour urine collection) Serum creatinine =< . mg/dL and/or calculated creatinine clearance >= mL/min (via Cockroft and Gault) Serum creatinine clearance >= ml/min (calculated by Cockroft-Gault formula) Calculated creatinine clearance (by Cockroft-Gault) >= ml/min or serum creatinine below g/dL Creatinine clearance (calculated by the Cockroft-Gault formula) >= ml/min Patients must have adequate renal function as evidenced by a serum creatinine ? . X ULN for the reference laboratory OR a calculated creatinine clearance of ? mL/min by the Cockroft-Gault equation. RANDOMIZED PHASE II (ARMS K AND L): Calculated creatinine clearance by Cockroft-Gault formula >= ml/min, obtained within weeks prior to registration Calculated creatinine clearance according to the formula of Cockroft and Gault >= mL/min Estimated serum creatinine clearance >= ml/min (using the Cockroft-Gault formula and/or serum creatinine =< . mg/dL Creatinine < . x ULN or creatinine clearance > ml/min according to Cockroft-Gault formula Within days prior to randomization: Serum creatinine =< . x ULN or measured or calculated creatinine clearance >= mL/min using the Cockroft-Gault formula for patients with creatinine levels > . x ULN for the lab Serum creatinine =< . x upper limit of normal (ULN) or creatinine clearance > mL/min based on the Cockroft-Gault equation Creatinine clearance >= ; creatinine clearance must be calculated using Cockroft-Gault formula Creatinine clearance (CrCL) >= calculated by Cockroft-Gault Patients must have a serum creatinine =< the IULN OR measured or calculated creatinine clearance >= mL/min using the Cockroft-Gault formula Creatinine clearance >= ml/min determined by -hour collection or estimated by the Cockroft-Gault formula Serum creatinine > . mg/dL or creatinine clearance < mL/min measured or calculated by Cockroft-Gault equation. Patients must have a serum creatinine =< the IULN AND measured or calculated creatinine clearance >= cc/min using the Cockroft-Gault formula REGISTRATION # - PRIOR TO CONSOLIDATION CHEMOTHERAPY: Patients must have a serum creatinine =< (IULN) AND measured of calculated creatinine clearance >= cc/min using the Cockroft-Gault formula Renal: Serum Creatinine ? . x ULN or creatinine clearance (CrCl) ? mL/min as calculated by the Cockroft-Gault method Part B: Renal function, as follows: creatinine clearance estimate ? mL/min and < mL/min by cockroft gault equation adjusted for body weight Renal: Serum Creatinine ? . x ULN or creatinine clearance (CrCl) ? mL/min as calculated by the Cockroft-Gault method Calculated creatinine clearance < mL/min (. mL/sec)using Cockroft-Gault formula Calculated creatinine clearance by Cockroft-Gault formula >= mL/min obtained within weeks prior to registration Calculated creatinine clearance by Cockroft-Gault formula >= ml/min Have a calculated creatinine clearance (Cockroft-Gault equation) > mL/min Calculated creatinine clearance (by Cockroft-Gault) of > ml/min Creatinine clearance; calculated creatinine clearance (CrCl) >= mL/min and < mL/min (Cockroft-Gault) unless the patient qualified based on hearing loss or neuropathy Estimated creatinine clearance of >= mL/min, calculated using the formula of Cockroft and Gault Estimated creatinine clearance < mL/min/.m^ (Cockroft-Gault formula) Have a creatinine clearance of >= ml/min, as calculated by the Cockroft-Gault formula Creatinine =< . X institutional ULN or calculated creatinine clearance >= ml/min as estimated using the Cockroft-Gault formula Either serum creatinine > mol/L (>. mg/dL), or creatinine clearance < mL/min calculated by the Cockroft Gault method, eventually confirmed by measured creatinine clearance (or measured glomerular filtration rate (GFR) using plasma clearance methods, not gamma camera-based) < mL/min (the measured creatinine clearance / GFR is required only as confirmatory exam). Serum creatinine >.x ULN or creatinine clearance < mL/min (Cockroft-Gault formula) Exclusion Criteria for Arm S and Arm P only: Calculated creatinine clearance (Cockroft-Gault) >= ml/min Calculated creatinine clearance >= ml/min (by Cockroft-Gault formula) within days prior to registration Creatinine (Cr) =< . mg/dL x upper limit of normal (ULN), creatinine clearance (CrCl) >= mL/min calculated by the Cockroft-Gault method Calculated (method of Cockroft-Gault) creatinine clearance < mL/min. Serum creatinine ? . mg/dL or calculated creatinine clearance (CrCl) of ? mL/hour by the Cockroft-Gault equation; Creatinine =< . mg/dL or calculated creatinine clearance (CrCL) >= mL/min using the Cockroft Gault equation Estimated (Cockroft-Gault formula) or measured creatinine clearance < mL/min Creatinine < . times the upper limit of normal (ULN) or creatinine clearance > mL/min (as measured or calculated by Cockroft-Gault formula) Estimated creatinine clearance of >= mL/min, calculated using the formula of Cockroft and Gault Creatinine ? . institutional ULN or Creatinine Clearance > ml/min (as calculated by the Cockroft-Gault equation) within days prior to randomization. Has adequate renal function, defined as: Creatinine clearance >= mL/minute, as calculated using the modified Cockroft Gault equation, ([{ - age in year Serum creatinine ? . times ULN and creatinine clearance (CLcr) ? mL/min according to the Cockroft-Gault formula Creatinine* < . g/dl *or a calculated creatinine clearance > /cc (using Cockroft-Gault formula) Serum creatinine =< . x ULN or serum creatinine > .- x ULN if calculated creatinine clearance (CrCl) is >= mL/min using the Cockroft-Gault equation Adequate renal function defined as calculated creatinine clearance greater than mL/min per the Cockroft and Gault formula. Patient has adequate renal function (calculated creatinine clearance of ? mL/min according to the Cockroft-Gault) Creatinine =< . mg/dL or calculated creatinine clearance (CrCL) >= mL/min using the Cockroft Gault equation Serum creatinine clearance >= ml/min (calculated with Cockroft-Gault formula); creatinine for children =<. mg/dl or =< times upper limit of normal for age (whichever is less) Creatinine clearance (Clcr) < mL/minute as estimated using the Cockroft-Gault formula or on dialysis Calculated creatinine clearance (CrCl) >= mL/min using the Cockroft Gault equation Actual creatinine clearance of < utilizing the Cockroft-Gault formula Estimated (Cockroft-Gault formula) or measured creatinine clearance < mL/min Brain malignancy or metastases to the brain Estimated creatinine clearance >= mL/min via Cockroft-Gault formula Patients with calculated creatinine clearance (Cockroft-Gault) less than mL/min