Participants with evidence of relapsed primary disease, or participants who have been treated for relapse after the allo-HSCT was performed.
For participants in Part :
Participants cannot have received more than two prior regimens Specifically for participants in Arm B:
Female participants must not be pregnant, breastfeeding or considering becoming pregnant during the study or for at least  or  months (for monotherapy and combination therapy participants, respectively) after the last dose of study drug.
Female research participants of childbearing age must not be pregnant as confirmed by a serum or urine pregnancy test within  week of start of treatment; participants must not be breast-feeding
Participants may not have been treated intratumorally with polyICLC.
Participants with symptomatic bradycardia
Female participants must either:
Female participants who:
Participants must have had prior therapy
Male or female study participants with sickle cell disease
Female participants who:
Female participants who:
Inclusion Criteria:\n\n          -  Study Participants must be  years or older.\n\n          -  Study Participants must have  sites of cutaneous metastatic melanoma that can not be\n             removed with surgery.\n\n          -  Study Participants may have been previously treated with chemotherapy or immunotherapy\n             but not with in  weeks of first dose of study treatment.
Female participants must not be breastfeeding
All Participants:
Female participants who:
For female participants of childbearing potential and male participants, willingness to use acceptable methods of contraception
Female participants who:
Female participants who:
Participants with intracardiac defibrillators.
Recipient of any drug with potential QT interval prolonging effects within  days prior to the first dose for all participants and while on treatment through the end of the study for crizotinib-treated participants only
Willing to use acceptable contraceptive measures as defined by the protocol during and at least for  months (male participants) or  months (female participants) after the last dose of study drug
Female participants who:
Female participants who:
Participants who have undergone allogenic stem cell transplant are ineligible unless they meet the following criteria, a) participants who are off all immunosuppressive therapy, b) participants who have no signs and/or symptoms of acute or chronic graft versus host disease, or c) participants must have appropriate hematology counts
Participants who were refractory to all lines of previous treatment(s) (ie, participants who had never responded to any therapies received).
Female participants who:
Must have also adhered to the guidelines of the RevAssist program (US participants), RevAid program (Canadian participants), iAccess program (Australian participants), RevMate program (Japanese participants) or The Lenalidomide Pregnancy Risk Minimisation Plan as outlined in the study Manual (all other participants who were not using commercial supplies)
Female participants who:
Female participants who:
Female participants
Female participants who:
Female participants who:
Inclusion criteria:\n\n        Phase  Part (dose escalation): Participants with a histologically confirmed solid tumor\n        including tumors of the central nervous system that was recurrent or refractory and for\n        which no further effective standard treatment was available. All participants must had\n        measurable disease. Participants with diffuse pontine glioma were eligible without a biopsy\n        after evidence of progressive disease post radiation therapy.\n\n        Phase  Part (safety and activity): Participants with recurrent or refractory high grade\n        glioma or diffuse intrinsic pontine glioma for whom no further effective therapy was\n        available. All participants must had measurable disease. Participants with diffuse pontine\n        glioma were eligible without a biopsy after evidence of progressive disease post radiation\n        therapy. Participants with a grade III or grade IV glioma must had pathologic confirmation\n        either at the time of initial diagnosis or at the time of recurrence.\n\n        Participants aged ? years and ? years\n\n        Participants met the body surface area (BSA) requirements to be eligible:\n\n          . Minimal BSA requirements for a particular dose level;\n\n          . During the Phase  part participants must had a BSA <. m at the time of enrollment\n\n          . During the Phase  part participants with a BSA ?. m were eligible, however the\n             actual dose of cabazitaxel for these participants were adjusted to a maximum dose\n             calculated with (capped at) the BSA of . m\n\n        Performance status by:\n\n          . Lansky score ? (participants ? years of age)\n\n          . Karnofsky score ?% (participants > years of age) Participants who were unable to\n             walk because of paralysis, but who were mobile in a wheelchair, were considered\n             ambulatory for the purpose of assessing the performance score.\n\n        Participants must had adequate liver, renal and marrow function as defined below:\n\n          . Total bilirubin ?. x the upper limit of normal (ULN) for age\n\n          . AST (SGOT) and ALT (SGPT) ?. x ULN\n\n          . Serum creatinine ?. x ULN for age or creatinine clearance ? mL/min/. m\n\n          . Absolute neutrophil count ?.x^ /L\n\n          . Platelets ?x^/L (transfusion independent)\n\n          . Hemoglobin ?. g/dL (could be transfused)\n\n        Female participants of child-bearing potential must had a negative pregnancy test ? days\n        before starting cabazitaxel treatment.\n\n        Male and female participants of reproductive potential must agreed to use adequate\n        contraception prior to study entry, for the duration of study participation and for \n        months following the last dose of cabazitaxel.\n\n        Written informed consent/assent prior to any study-specific procedures. Consent must be\n        obtained from the participant and/or parent(s) or legal guardian(s) and the signature of at\n        least one parent or guardian was required. Investigators also obtained assent of\n        participants according to local, regional or national guidelines.\n\n        Participants must have recovered from the acute toxic effects of all prior therapy to ?\n        grade  before entering the study.\n\n        Exclusion criteria:\n\n        Prior treatment within the following timeframes:\n\n          . Systemic anti-cancer treatment within  weeks ( weeks for nitrosourea, mitomycin and\n             monoclonal antibodies including bevacizumab)\n\n          . Surgery or smaller field radiation therapy within  weeks\n\n          . Treatment with an investigational agent within  weeks or within  half-lives of the\n             agent, whichever was longer Craniospinal or other large field radiation therapy\n             (defined as >% of bone marrow irradiated) within  months prior to the first dose.\n\n        Prior systemic radioisotope therapy (this did not include diagnostic imaging or\n        radioimmunoconjugates lacking myelosuppressive properties) or total body irradiation.\n\n        Prior bone marrow or stem cell transplant\n\n        Participants with any clinically significant illness that, in the investigator's opinion,\n        could not be adequately controlled with appropriate therapy, would compromise a\n        participant's ability to tolerate cabazitaxel or result in inability to assess toxicity.\n        This included, but was not limited to uncontrolled intercurrent illness including ongoing\n        or active infection, cardiac disease, renal impairment, planned surgery or psychiatric\n        illness/social situations that would limit compliance with study requirements.\n\n        Known human immunodeficiency virus (HIV) infection or acquired immunodeficiency-syndrome\n        (AIDS)-related disease Known history of hepatitis C or known active hepatitis B infection.\n        Pregnant or breast feeding women Treatment with strong inhibitors or strong inducers of\n        CYPA or enzyme inducing anti-epileptic drugs (EIAED) within  days prior to first dose\n        of cabazitaxel and for the duration of study. Non-EIAEDs were permitted.\n\n        Known history of hypersensitivity to taxanes or polysorbate  or G-CSF. Participation in\n        another interventional clinical trial and/or concurrent treatment with any investigational\n        drug.\n\n        Participants not able to comply with scheduled visits, treatment plans, laboratory tests,\n        and other study procedures.\n\n        The above information was not intended to contain all considerations relevant to a\n        participant's potential participation in a clinical trial.
Participants who have undergone hysterectomy
Female participants must not be pregnant or breast-feeding. Female participants of childbearing potential and fertile male participants must agree to use a highly effective contraceptive during the trial and for a period of at least  months following the last administration of trial drug(s)
Female participants who:
Pregnant participants will not be entered on this study
ALL PARTICIPANTS
PATIENT PARTICIPANTS:
Illiterate participants
Deaf participants
PATIENT PARTICIPANTS:
Female participants will be excluded from the trial if they become pregnant; female participants can use whichever method of contraception that they prefer
The participants SISCCA must not have been ablated
Concurrent malignancy. Participants with carcinoma in situ of any origin and participants with prior malignancies in remission may be eligible with sponsor approval.
PATIENT PARTICIPANTS
CHILD PARTICIPANTS:
ADULT PARTICIPANTS:
PATIENT PARTICIPANTS:
GROUPS , , AND : \All participants described above
Female participants of childbearing age must not be lactating
Females participants must complete the Female Enrollment Form. Childbearing potential participants must agree to use one of the medically accepted forms of contraception for a period of one month after study participation. Female participants who meet the criteria for non-childbearing will still complete the Female Enrollment Form, but are not restricted to the use of contraception following study participation.
Female participants who: