Hemoglobin (Hb)Ac =< .% Hgb-AC ? .%; Participants with poorly controlled diabetes defined as a hemoglobin Ac (HgbAc) >= .% Glycated hemoglobin (Hb Ac) =< .%, or .-.% with a normal fasting glucose Hgb-AC =< .% Hemoglobin Ac < % Glycosylated hemoglobin (Hgb Ac) =< .% Glycated hemoglobin (Hgb-AC) level of =< .%. Abnormal complete blood count, comprehensive metabolic panel, urine, hemoglobin (Hgb) Ac (study physician discretion) Hemoglobin AC < .%, within weeks of registration Hemoglobin AC (HbAC) < .% Poorly controlled diabetes defined by hemoglobin AC > . at screening. Uncontrolled diabetes (defined as Hgb AC > .%) Hemoglobin Ac (HbAc) < % obtained within days prior to sub-study registration Hemoglobin Ac (HbAc) =< % Within days of subject registration: Hemoglobin (HB)Ac =< % History of peripheral vascular disease (PVD) that has required surgical or percutaneous intervention or documented PVD that requires medical management with medications such as acetylsalicylic acid (ASA) + clopidogrel; patients with diabetes that is not well controlled are excluded from participation; not well controlled is defined as a hemoglobin (Hgb) AC of greater than .% Hemoglobin AC (HbAC) =< if patient has diabetes Patients must not have uncontrolled diabetes mellitus (defined by a hemoglobin [Hgb] Ac > ) obtained within days prior to registration; optimal glucose control (Hgb Ac =< ) must be achieved before registration and monitored during protocol treatment SUB-PROTOCOL AIM A: Uncontrolled diabetes mellitus as defined by hemoglobin AC (HbAc) > % despite adequate therapy; unstable coronary artery disease or myocardial infarction during preceding months; or hypertension uncontrolled by medication Participants with a type diabetes mellitus are eligible if adequate control of blood glucose level is obtained by oral anti-diabetic agents as documented by hemoglobin Ac (HbAc) <%. Diabetes mellitus with poor glycemic control (documented hemoglobin Ac > % within weeks prior to study entry) Hemoglobin Ac =< % Glycosylated hemoglobin (Hgb AC) > .% Has a history of autoimmune disorders, including uncontrolled diabetes (\uncontrolled\ defined as Hemoglobin Ac ? % in days prior to study). Uncontrolled diabetes mellitus as defined by hemoglobin (Hb)Ac > % within days prior to registration despite adequate therapy Hemoglobin Ac (HbAc) =< % Planning to initiate adjuvant or neoadjuvant anthracycline (AC) chemotherapy (doxorubicin [doxorubicin hydrochloride] mg/m^ and cyclophosphamide mg/m^ every - weeks x cycles)\r\n* Note: \r\n** Participants may be planning to receive additional adjuvant therapy after the completion of AC chemotherapy\r\n** Receipt of all standard chemotherapy and/or targeted therapy regimens after AC that deemed clinically appropriate by the treating physician are permitted; for example, patients may receive taxanes or carboplatin/paclitaxel; Her positive patients may receive trastuzumab with or without pertuzumab\r\n** HER positive patients must be planning to initiate trastuzumab therapy after AC chemotherapy Hemoglobin (Hgb) AC =< % Uncontrolled diabetes defined as a hemoglobin AC level > % (therapeutic action is indicated at greater than %) Obtained within weeks from study entry: Hemoglobin Ac (HgBAc) =< % Part only: (a) Patients with active or a history of glucose intolerance or diabetes mellitus and (b) Hemoglobin Ac ?% Diabetes mellitus requiring insulin treatment or subjects with a hemoglobin AC (HbAC) >%. Hemoglobin AC (HBAC) < .% Have poorly controlled diabetes (hemoglobin [HgB] AC >= %) Poorly controlled diabetes (hemoglobin [Hgb] AC > ) Hemoglobin (Hgb) AC =< % Uncontrolled diabetes defined as a hemoglobin AC level > % (therapeutic action is indicated at greater than %) Hemoglobin (Hgb) AC =< % Uncontrolled diabetes defined as a hemoglobin AC level > % (therapeutic action is indicated at greater than %) If diabetic and taking insulin or oral anti-diabetic therapy, must have hemoglobin Ac (HbAc) =< %, or a fasting serum glucose =< % ULN Patient received previous treatment with oral AC For patients with diabetes, hemoglobin AC test must have been performed =< days prior to registration Hemoglobin Ac > .% or diabetes requiring insulin therapy Participants must have no uncontrolled diabetes mellitus defined as glycosylated hemoglobin (Hgb AC) > % Subjects who have diabetes with a hemoglobin (Hgb) Ac > Glycosylated hemoglobin (Hb Ac) =< % Poorly controlled diabetes (hemoglobin Ac [Hgb AC] > or random blood glucose > mg/dL) Patients with hemoglobin ac > . or who are being actively treated for diabetes Hemoglobin AC > .% Participants with known uncontrolled diabetes, defined as a hemoglobin AC of > %