Investigational treatment - weeks Patients who have received any chemotherapy or investigational treatment within weeks of study start Administration of an investigational therapeutic within days of treatment start Investigational drug within weeks of proposed step start date Any investigational therapy within days prior to the start of Cycle Patients must not have received an investigational anti-cancer drug within two weeks of start of protocol treatment Has received an investigational therapeutic drug within the last weeks prior to start of study treatment, or is scheduled to receive one during the treatment period Received investigational treatment in another clinical study within weeks prior to the initiation of investigational treatment; Chemotherapy or other investigational therapy within days prior to the start of Cycle Receipt of any other investigational agents within weeks preceding the start of study treatment Participants who received any investigational treatment within weeks of study start If a subject previously received investigational treatment, the last dose of investigational treatment was administered within weeks of Day of the study or adverse event(s) attributable to investigational treatment have not resolved to Grade or better. Patients who are using other investigational agents or who had received investigational drugs =< weeks prior to study treatment start Chemotherapy or other investigational therapy within days prior to the start of Cycle Any investigational treatments for any condition within weeks prior to the start of study treatment. Exposure to another investigational drug within weeks prior to start of study treatment. Investigational agents within weeks before start of study therapy Concomitant or recent treatment with other investigational drug (within weeks or elimination half life times prior to anticipated start of study treatment). Treatment with any chemotherapy or investigational agents within weeks of the start of study treatment; subjects must have recovered from toxicities of prior therapy Any treatment with investigational drugs within days before the start of the study Use of any investigational drug within the past weeks before start of study medication or concomitantly with this study except for investigational immune-stimulatory therapy (e.g. checkpoint-regulator targeted treatment). The minimum washout period should be weeks before starting the study medication. Patients who have received any investigational medication within weeks of enrollment, or who are scheduled to receive an investigational drug during the course of the study Received any investigational treatment within weeks prior to the start of study medication; Patients who have received any investigational medication within weeks of enrollment, or who are scheduled to receive an investigational drug during the course of the study Treatment with investigational or approved anti-cancer drugs within weeks before the start of BAY treatment and during the study (glioma patients must have completed chemoradiotherapy at least weeks prior to screening and their baseline scan; see inclusion criteria #)