Uncontrolled hypertension defined as sustained systolic blood pressure (BP) > mmHg or diastolic BP > mmHg; (patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria) Uncontrolled high blood pressure defined as systolic blood pressure (BP) > mmHg or diastolic BP mmHg with or without anti-hypertensive medication; patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria Uncontrolled high blood pressure defined as systolic blood pressure (BP) greater than or equal to mmHg or diastolic BP greater than or equal to mmHg with or without anti-hypertensive medication. Patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria. Uncontrolled hypertension, defined as systolic blood pressure (BP) > mmHg or diastolic BP > mmHg. Uncontrolled or poorly controlled hypertension (systolic blood pressure [BP] >= mmHg or diastolic BP >= mmHg); Note: an isolated reading that is not sustained will be permitted Uncontrolled hypertension defined as sustained systolic BP > mmHg or diastolic BP > mmHg. (Patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria.) Patients requiring greater than or equal to BP medications are not eligible. Systolic blood pressure (BP) not deemed clinically controlled by the investigator. No grade or hypertension (systolic blood pressure [BP] > and or diastolic BP > ) that cannot be controlled with medication prior to registration Uncontrolled hypertension, i.e., blood pressure (BP) of >= /; patients who have a history of hypertension controlled by medication must be on a stable dose (for at least one month) and meet all other inclusion criteria; or Uncontrolled hypertension (blood pressure [BP] > / mmHg) Uncontrolled hypertension (systolic blood pressure [BP] > mmHg or diastolic BP > mmHg) Uncontrolled hypertension. Patients with a history of hypertension are allowed provided blood pressure is controlled by anti-hypertensive therapy. Note that this is NOT a criterion related to particular blood pressure (BP) results at the time of assessment for eligibility, nor does it apply to acute BP excursions that are related to iatrogenic causes, acute pain or other transient, reversible causes Chronically uncontrolled hypertension, defined conventionally as consistent systolic pressures above or diastolic pressures above despite anti-hypertensive therapy. Note that this is NOT a criterion related to particular blood pressure (BP) results at the time of assessment for eligibility, nor does it apply to acute BP excursions that are related to iatrogenic causes, acute pain or other transient, reversible causes. (for example doctors visit related stress i.e. \white coat syndrome\. Uncontrolled cardiac disease, including unstable angina, uncontrolled hypertension (i.e. sustained systolic BP > mmHg or diastolic BP > mmHg), or need to change medication due to lack of disease control within weeks prior to the provision of consent; Uncontrolled hypertension defined as a systolic blood pressure (BP) > mmHg or diastolic BP > mmHg, with or without anti-hypertensive medications Uncontrolled hypertension (HTN); sustained blood pressure (BP) greater than / mmHg Blood pressure (BP) < mmHg (systolic) and < mmHg (diastolic); initiation or adjustment of BP medication is permitted prior to registration provided that the average of three BP readings at a visit prior to registration is < / mmHg; NOTE: all patients with secretory pheochromocytoma or paraganglioma are REQUIRED to: ) be evaluated in consultation by a hypertension specialist with specific experience in the management of hypertension in the setting of catecholamine-secreting tumors (usually an endocrinologist, nephrologist, or a cardiologist), and in the setting of hormone-associated hypertension) receive alpha- and beta-adrenergic blockade for at least - days prior to initiation of lenvatinib; the hypertension specialist of record for each patient should be committed to closely following the patient during the clinical study with evaluation by said specialist required at cycle and and thereafter on an as needed basis Uncontrolled hypertension (systolic blood pressure [BP] >= mmHg or diastolic BP >= mmHg) or other medical condition that could jeopardize the assessment of toxicity on study Uncontrolled hypertension (systolic blood pressure [BP] >= mmHg or diastolic BP >= mmHg); patients with a history of hypertension are allowed provided blood pressure is controlled by anti-hypertensive treatment Systolic blood pressure (BP) > mmHg or diastolic BP > mmHg despite optimal medical management Uncontrolled hypertension, i.e., blood pressure (BP) of >= /; patients who have a history of hypertension controlled by medication must be on a stable dose and meet all other inclusion criteria; or Resting systolic blood pressure (BP) < mmHg Hypertension defined as systolic BP >= mmHg or diastolic BP >= mmHg despite optimal medical management Uncontrolled hypertension defined as a systolic BP greater than mmHg or diastolic BP greater than mmHg, with or without anti-hypertensive medications. (Patients with hypertension that is well controlled on medication are eligible.) Severe hypertension (diastolic BP > on medication). Uncontrolled hypertension (systolic blood pressure [BP] >= mmHg or diastolic BP >= mmHg); patients with a history of hypertension are allowed provided blood pressure is controlled by anti-hypertensive treatment Uncontrolled high blood pressure defined as systolic BP greater than or equal to mmHg or diastolic BP greater than or equal to mmHg with or without anti-hypertensive medication. Patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria. uncontrolled hypertension (systolic BP> mmHg or diastolic BP > mmHg despite antihypertensive treatment); Severe hypertension (diastolic BP > on medication) Uncontrolled hypertension defined as sustained systolic blood pressure (BP) > mmHg or diastolic BP > mmHg; (patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria) Patients with uncontrolled hypertension (requirement for more than blood pressure [BP] medications or grade or higher BP elevation while on adequate doses of not more than antihypertensive agents) are excluded from the study Mean arterial blood pressure (BP) of less than mmHg No history of the following\r\n* Prior brain metastases\r\n* Leptomeningeal disease\r\n* Seizures\r\n* Class or congestive heart failure\r\n* Uncontrolled hypertension (systolic blood pressure [BP] > mmHg or diastolic BP > mmHg) despite optimal medical management\r\n* Major surgery =< weeks of registration Have uncontrolled hypertension (systolic blood pressure [BP] > mmHg or diastolic BP > mmHg). Resting systolic blood pressure (BP) < mmHg Hypertension defined as systolic BP >= mmHg or diastolic BP >= mmHg despite optimal medical management Poorly-controlled hypertension as defined blood pressure (BP) > / mmHg, or systolic (S) BP > mmHg when diastolic (D) BP < mmHg, on at least repeated determinations on separate days within months prior to study enrollment Uncontrolled hypertension defined as sustained systolic blood pressure (BP) > mmHg or diastolic BP > mmHg; (patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria) Blood pressure (BP) > mmHg (systolic) and > mmHg (diastolic); initiation or adjustment of BP medication is permitted prior to registration provided that the average of three BP readings at a visit prior to registration is < / mmHg Uncontrolled hypertension (systolic blood pressure [BP] >= mmHg or diastolic BP >= mmHg); patients with a history of hypertension are allowed provided blood pressure is controlled by anti-hypertensive therapy Systolic blood pressure (BP) > mmHg or diastolic BP > mmHg. uncontrolled hypertension (systolic BP ? mmHg or diastolic BP ? mmHg) at screening, despite optimal antihypertensive therapy, Severe hypertension (diastolic BP > on medication) Uncontrolled hypertension, i.e., blood pressure (BP) of >= /; patients who have a history of hypertension controlled by medication must be on a stable dose (for at least one month) and meet all other inclusion criteria Uncontrolled hypertension (systolic blood pressure [BP] >= mmHg or diastolic BP >= mmHg); patients with a history of hypertension are allowed provided blood pressure is controlled by anti-hypertensive treatment Uncontrolled hypertension (systolic blood pressure [BP] >= mmHg or diastolic BP >= mmHg); patients with a history of hypertension are allowed provided blood pressure is controlled by anti-hypertensive treatment Subjects with uncontrolled hypertension (systolic blood pressure [BP] > mmHg or diastolic BP > mmHg) at screening are excluded. Subjects requiring or more medications to control hypertension are eligible with Medical Monitor approval. Patients with a history of hypertension MUST have hypertension adequately controlled (blood pressure [BP] < /) with appropriate anti-hypertensive therapy or diet prior to study entry; Note: To be eligible a subject must have an average of BP below / based on separate measures; if the subject has a record of BP recordings taken at home, =< % of BPs taken should have numbers > / Patients must have blood pressure (BP) no greater than mmHg (systolic) and mmHg (diastolic) for eligibility; initiation or adjustment of BP medication is permitted prior to study entry provided that the average of three BP readings at a visit prior to enrollment is less than / mmHg Blood pressure (BP) no greater than mmHg (systolic) and mmHg (diastolic) for eligibility; initiation or adjustment of BP medication is permitted prior to study entry provided that the average of three BP readings on baseline assessment prior to enrollment is less than / mmHg Uncontrolled hypertension defined as systolic blood pressure (BP) >= mmHg or diastolic BP >= mmHg with or without antihypertensive medication, based on a mean of measurements at approximately -minute intervals Significant co-morbidity that could affect the safety or evaluability of participants, specifically including: \r\n* Chronically uncontrolled hypertension, defined conventionally as consistent systolic pressures above or diastolic pressures above despite therapy; note that this may be better established with home blood pressure (BP) readings than with clinic visit results; note further that this is NOT a criterion related to particular BP results at the time of assessment for eligibility, nor does it apply to acute BP excursions that are related to iatrogenic causes, acute pain or other transient, reversible causes; the intent is to exclude patients that may have unrecognized renal damage from chronic, uncontrolled hypertension, NOT to exclude patients who may be hypertensive acutely; there are no absolute criteria for BP readings with respect to eligibility (as determined by treating physician)\r\n* Uncontrolled diabetes mellitus, defined as: hemoglobin (Hgb) Ac > .%; or symptomatic hypoglycemic episodes > per week during the two months prior to eligibility evaluation; or more than glucose excursion to > mg/dL in prior two months--unless clearly iatrogenic and the cause has been eliminated \r\n* Lung disease requiring supplemental oxygen \r\n* Known chronic liver disease causing either fibrosis or synthetic dysfunction \r\n* Known human immunodeficiency virus (HIV) infection \r\n* Overt psychosis, mental disability or being otherwise incompetent to grant informed consent or a history of non-compliance with medical care Uncontrolled hypertension (BP ?/ mmHg despite medical therapy) Uncontrolled hypertension (blood pressure [BP] > diastolic despite treatment with maximum doses of at least simultaneous or concurrent antihypertensives over a -month period) Severe hypertension (diastolic blood pressure [BP] > on medication) Uncontrolled hypertension (systolic blood pressure [BP] ? millimeters of mercury [mmHg] or diastolic BP ? mmHg). Uncontrolled hypertension (systolic blood pressure [BP] >= mmHg or diastolic BP >= mmHg); patients with a history of hypertension are allowed provided blood pressure is controlled by anti-hypertensive treatment Mean arterial blood pressure (BP) of less than mmHg. Patients must have resting blood pressure (BP) no greater than mmHg (systolic) or mmHg (diastolic) for eligibility; initiation or adjustment of BP medication is permitted prior to study entry Uncontrolled hypertension, i.e., blood pressure (BP) of >= /; patients who have a history of hypertension controlled by medication must be on a stable dose (for at least one month) and meet all other inclusion criteria Uncontrolled hypertension (systolic blood pressure [BP] >= mmHg or diastolic BP >= mmHg) despite medical treatment; patients with a history of hypertension are allowed provided blood pressure is controlled by anti-hypertension treatment Subjects must have blood pressure (BP) no greater than mmHg (systolic) and mmHg (diastolic) for eligibility; initiation or adjustment of BP medication is permitted prior to study entry provided that the average of three BP readings at the time of enrollment is =< / mmHg Patients must have blood pressure (BP) no greater than mmHg (systolic) and mmHg (diastolic) for eligibility; initiation or adjustment of BP medication is permitted prior to study entry provided that the BP reading prior to enrollment is no greater than / mmHg Uncontrolled hypertension, defined as systolic BP > or diastolic > despite therapy. Uncontrolled hypertension (systolic blood pressure [BP] >= mmHg or diastolic BP >= mmHg); patients with a history of hypertension are allowed provided blood pressure is controlled by anti-hypertensive treatment No uncontrolled hypertension (BP >/mmHg despite full doses of anti-hypertensive medication). Baseline arterial blood pressure (BP) >= / mmHg, despite pharmacologic treatment with antihypertensive agents; if the arterial BP measurements at screening are >= / mmHg in a patient not on pharmacologic treatment for hypertension (HTN), we will initiate pharmacologic therapy and reassess the parameters after week; at that time, patient will be eligible for enrollment on the study if arterial BP is found < / mmHg on antihypertensive therapy Patients with uncontrolled hypertension (defined as sustained stage hypertension, i.e., systolic blood pressure [BP] >= mmHg or diastolic BP >= mmHg) with or without medical therapy Poorly controlled hypertension (systolic blood pressure [BP] >= mmHg or diastolic BP >= mmHg) on three or more readings in the past months Severe hypertension (diastolic BP > on medication) All patients must also have pre-op blood pressures (BP) to average for determining individual perioperative BP goal; it is preferred to utilize office visit BP's to reduce \whitecoat\ effect seen the morning of surgery Uncontrolled hypertension, i.e., blood pressure (BP) of >= /; patients who have a history of hypertension controlled by medication must be on a stable dose (for at least one month) and meet all other inclusion criteria; or Uncontrolled hypertension (systolic blood pressure [BP] > mmHg or diastolic BP > mmHg), or as determined by the investigator during screening. Systolic/diastolic blood pressure (BP) greater than or equal to /, or below / (one re-screen allowed) Uncontrolled high blood pressure (BP) >= /; persons can be re-screened after controlled Severe hypertension (diastolic BP > on medication) Uncontrolled hypertension (systolic blood pressure [BP] >= mmHg or diastolic BP >= mmHg) Uncontrolled hypertension, blood pressure (BP) > / mmHg; patients with elevated BP may enroll once BP is corrected