Known contraindications to radiotherapy Patients are known to have contraindications to radiotherapy Have known contraindications or sensitivities to the study drug For Part I: patients with known contraindications to platinum agents are excluded Contraindications to treatment with: Contraindications to radiation Known contraindications to radiotherapy Patients with contraindications to surgery; No known contraindications to intended therapies Known contraindications to peripheral nerve block placement Subject has contraindications for radiation Patients with contraindications to MR Patients with known contraindications for whole body MR imaging (e.g., pacemakers, recent surgery, brain vascular clips, etc.) will be excluded from the study Contraindications for surgery