Untreated or active central nervous system metastases Active or untreated central nervous system (CNS) metastases Primary central nervous system (CNS) malignancy, or untreated/active CNS metastases Any untreated central nervous system (CNS) lesion. Active or untreated central nervous system (CNS) metastases Patients with untreated central nervous system metastases Untreated central nervous system (CNS) metastases Known, current central nervous system disease involvement or untreated brain metastases Untreated central nervous system (CNS) metastases Active or untreated central nervous system (CNS) metastases Exclusions Related to Cardiovascular Disease Active, untreated central nervous system (CNS) metastases Patients with active and/or untreated central nervous system (CNS) lymphoma will not be eligible Patients with known brain metastases, active infection, or untreated central nervous system (CNS) leukemia Untreated or active central nervous system metastases - Ongoing or recent (within years) evidence of significant autoimmune disease Patients with untreated brain metastases/central nervous system (CNS) disease will be excluded Active or untreated central nervous system (CNS) metastases Active, untreated central nervous system metastases. Known untreated central nervous system (CNS) metastases; leptomeningeal disease will be an absolute exclusion criterion due to limited life expectancy Active, untreated central nervous system metastases. Known active or untreated central nervous system (CNS) metastases. - Pregnant, planning to become pregnant within months of treatment, or nursing. Primary central nervous system (CNS) malignancy, or untreated/active CNS metastases Known and untreated brain metastases. Patients with primary CNS (central nervous system) malignancies are excluded. Known and untreated, or active central nervous system (CNS) metastases (progressing or requiring treatment) Primary central nervous system (CNS) malignancy, or untreated/active CNS metastases Participant has untreated central nervous system (CNS) metastases. Untreated or active/progressing Central Nervous system (CNS) metastases No untreated central nervous system metastases, or if treated must be neurologically stable for at least weeks prior to enrollment Known untreated or active central nervous system (CNS) metastases Known, current central nervous system disease involvement or untreated brain metastases Untreated central nervous system metastatic disease l Untreated central nervous system (CNS) metastases Known active or untreated central nervous system (CNS) metastases Patients with untreated central nervous system (CNS) or epidural tumor Any untreated central nervous system (CNS) lesion Presence of untreated/active central nervous system (CNS) metastases Has active or untreated brain or central nervous system metastases. Active, untreated central nervous system metastases. Active, untreated central nervous system metastases. Active or untreated central nervous system (CNS) metastases Active or untreated central nervous system (CNS) lesions Untreated central nervous system (CNS) metastatic disease Presence of clinically apparent untreated central nervous system metastases. Untreated brain or central nervous system (CNS) metastases Untreated central nervous system metastases Active or untreated central nervous system (CNS) metastases Active or untreated central nervous system (CNS) metastases Untreated or active central nervous system (CNS) metastases. Untreated central nervous system metastases Untreated or active brain metastases or central nervous system cancer, as defined per protocol Untreated or active cerebral nervous system metastases Known untreated or active central nervous system (CNS) metastases Untreated or active central nervous system (CNS) metastases Primary central nervous system (CNS) malignancy or untreated/active CNS metastases Untreated central nervous system (CNS) metastases. Known and untreated, or active central nervous system metastases Known primary central nervous system (CNS) malignancy or untreated or active CNS metastases Subjects with untreated Central nervous system (CNS) metastases are excluded Active, untreated central nervous system metastases. Criteria , Active or untreated central nervous system (CNS) metastases per CT or MRI evaluation during screening