Significant medical comorbidities, including uncontrolled hypertension (diastolic blood pressure greater than  mm Hg), unstable angina, congestive heart failure (greater than New York Heart Association class II), severe uncontrolled ventricular arrhythmias, or electrocardiographic evidence of acute ischemia, poorly controlled diabetes, severe chronic pulmonary disease, coronary angioplasty, or myocardial infarction within  months prior to screening, or uncontrolled atrial or ventricular cardiac arrhythmias.
Patients with significant medical comorbidities, including uncontrolled hypertension (diastolic blood pressure [BP] >  mmHg), unstable angina, congestive heart failure (> New York Heart Association [NYHA] class II), poorly controlled diabetes, severe chronic pulmonary disease, coronary angioplasty or myocardial infarction within the last  months, or uncontrolled atrial or ventricular cardiac arrhythmias
Significant medical comorbidities, including uncontrolled hypertension (diastolic blood pressure > mm Hg), unstable angina, congestive heart failure (greater than New York Heart Association class II), severe uncontrolled ventricular arrhythmias, electrocardiographic evidence of acute ischemia, poorly controlled diabetes, severe chronic pulmonary disease, coronary angioplasty, myocardial infarction within  months prior to Screening, or uncontrolled atrial or ventricular cardiac arrhythmias.
Significant medical comorbidities, including uncontrolled hypertension (diastolic blood pressure greater than  mm Hg), unstable angina, congestive heart failure (greater than New York Heart Association class II), severe uncontrolled ventricular arrhythmias, or electrocardiographic evidence of acute ischemia, poorly controlled diabetes, severe chronic pulmonary disease, coronary angioplasty, or myocardial infarction within  months prior to screening, or uncontrolled atrial or ventricular cardiac arrhythmias.
Significant medical comorbidities, including uncontrolled hypertension (diastolic blood pressure > mm Hg), unstable angina, congestive heart failure (greater than New York Heart Association class II), severe uncontrolled ventricular arrhythmias, electrocardiographic evidence of acute ischemia, poorly controlled diabetes, severe chronic pulmonary disease, coronary angioplasty, myocardial infarction within  months prior to Screening, or uncontrolled atrial or ventricular cardiac arrhythmias.