Patients must be able to swallow tablets whole Patients must be able to swallow tablets Patients must be able to swallow tablets Patients must be able to swallow intact tablets Patients must be able to swallow intact tablets Patients must be able to swallow intact tablets Patients must be able to swallow intact tablets Ability to swallow tablets Patients must be able to swallow tablets Ability to swallow the investigational product tablets. Participants must be able to swallow ribociclib capsules or tablets Inability to swallow intact tablets Inability to swallow intact tablets Must be able to swallow ribociclib and everolimus capsules/tablets Must be able to swallow LEE and everolimus capsules/tablets Patients must have the ability to swallow tablets Patients must be able to swallow tablets (or applesauce, if part of bioavailability \crushed\ six patient cohort) Subjects that cannot swallow tablets. Able to swallow tablets. Ability to swallow oral tablets without difficulty Patients must be able to swallow intact tablets Patients who are not able to swallow intact tablets are not eligible Inability to swallow intact tablets Inability to swallow intact tablets Inability to swallow intact tablets Has an inability to swallow tablets or capsules Able to swallow bicalutamide and ribociclib capsules/tablets. Be able to swallow tablets. Are able to swallow capsules and tablets. Patients must be able to swallow intact tablets; patients who cannot swallow intact tablets are not eligible Able to swallow the study drugs whole as tablets Patients must be able to swallow whole tablets CAPMATINIB EXCLUSION CRITERIA: Inability to swallow intact tablets or capsules CERITINIB EXCLUSION CRITERIA: Inability to swallow intact tablets or capsules REGORAFENIB EXCLUSION CRITERIA: Inability to swallow intact tablets or capsules ENTRECTINIB EXCLUSION CRITERIA: Inability to swallow intact tablets or capsules Inability to swallow tablets or capsules Patients who cannot swallow whole tablets (i.e. medication tablets) Willing to take abiraterone acetate on an empty stomach, and should be able to swallow tablets whole, without crushing/chewing tablets; must have the ability to swallow, retain, and absorb oral medication Part E: Are able to swallow capsules or tablets Inability to swallow intact tablets or inability to take pembrolizumab or cabozantinib Ability to swallow epacadostat tablets. In case Incyte at a later time point provides support to administer epacadostat tablets parenterally (via gastrostomy [G]-tube), such administration would also be acceptable as an alternative (once official documentation has been obtained from Incyte) The subject must be able to swallow tablets, or receive tablets crushed and/or dispensed in water via nasogastric or orogastric tube. Patients must be able to swallow tablets and have no significant impairment in gastrointestinal absorption Patients who are not able to swallow capsules or tablets Must be able to swallow ribociclib and tamoxifen capsules/tablets Patients must be able to swallow tablets whole Patients must be able to swallow capsules/tablets Patients must be able to swallow whole tablets; nasogastric or gastrostomy (G) tube administration is not allowed; tablets must not be crushed or chewed For subjects to be enrolled in Cohort : Able to swallow and retain orally administered tablets Patients must have the ability to swallow tablets Are able to swallow capsules and tablets. Any condition causing an inability to swallow tablets. Must be able to swallow ribociclib / placebo capsules/tablets Inability to swallow tablets Inability to swallow tablets or capsules Able to swallow tablets Inability to swallow tablets Patients must be willing and able to swallow oral tablets Patients must have the ability to swallow tablets Inability to swallow tablets or use of a feeding tube Are able to swallow tablets Patients must be able to swallow tablets Patients with an inability to swallow tablets or capsules Are able to swallow capsules or tablets Ability to swallow tablets without difficulty; Patients must be able to swallow tablets Able to swallow tablets Ability to swallow intact palbociclib capsules and bicalutamide tablets Patients must be able to swallow whole tablets (for MK-); nasogastric or gastrostomy (G) tube administration is not allowed; tablets must not be crushed or chewed Patients who are not able to swallow capsules or tablets Ability to swallow tablets. Patients must be able to swallow whole tablets; nasogastric or gastrostomy (G) tube administration is not allowed; tablets must not be crushed or chewed Patients must be able to swallow tablets whole, without crushing Patients must be able to swallow whole tablets; tablets must not be crushed or chewed Patients must be able to swallow whole tablets and capsules Inability to swallow tablets for everolimus arm Patient must be able to swallow whole tablets Patients must be able to swallow tablets Patients must be able to swallow tablets Must be able to swallow tablets and capsules Inability to swallow tablets Inability to swallow tablets Ability to swallow oral tablets Ability to swallow and tolerate oral tablets GENERAL INCLUSION CRITERIA FOR SUBPROTOCOLS: Patients must be able to swallow intact capsules/tablets, unless otherwise specified in the subprotocol to which they are assigned Subjects must be able to swallow capsules/tablets