Persistent uncontrolled hypertension (systolic > mmHg/ diastolic > mmHg Exclusion Criteria Part D Patients with uncontrolled hypertension (>= / mmHg) are NOT eligible for participation Patients with uncontrolled or poorly-controlled hypertension (> mmHg systolic or > mmHg diastolic for > weeks) despite standard medical management Patients with uncontrolled hypertension (> / mmHg) are NOT eligible for participation Uncontrolled or poorly controlled hypertension (> mmHg systolic or > mmHg diastolic for > weeks) despite standard medical management Uncontrolled hypertension (> / mmHg) Hypertension that is not controlled by standard medication (to / mmHg or below), The patient has uncontrolled or poorly controlled hypertension (> mmHg systolic or > mmHg diastolic) at the time of enrollment Poorly controlled diabetes mellitus or hypertension (e.g., systolic > mmHg or diastolic > mmHg) Patients who have uncontrolled hypertension (defined as sustained systolic blood pressure >= mmHg or diastolic >= mmHg) Patients with diagnosed uncontrolled hypertension (> / mmHg) are to be excluded Uncontrolled arterial hypertension defined by blood pressure > mmHg systolic and/or mmHg diastolic at rest (average consecutive readings at least minutes apart) despite appropriate medical therapy The patient has uncontrolled or poorly-controlled hypertension (> mmHg systolic or > mmHg diastolic for > weeks) despite standard medical management Patients who have uncontrolled hypertension (defined as sustained systolic blood pressure >= mmHg or diastolic >= mmHg) Patients who have uncontrolled hypertension (systolic > mmHg and/or diastolic > mmHg); it is permissible to start treatment for hypertension prior to randomization Uncontrolled or poorly-controlled hypertension (> mmHg systolic or > mmHg diastolic for > weeks) despite standard medical management Hypertension that is not controlled by standard medication (to / mmHg or below) Uncontrolled hypertension (> / mmHg) Patients who have uncontrolled or poorly-controlled hypertension (> mmHg systolic or > mmHg diastolic for > weeks) despite standard medical management Uncontrolled arterial hypertension (systolic blood pressure > mmHg or diastolic > mmHg) despite appropriate medical therapy Have uncontrolled hypertension, as defined in CTCAE Version ., prior to initiating study treatment, despite antihypertensive intervention. CTCAE Version . defines uncontrolled hypertension as Grade > hypertension; clinically, the participant continues to experience elevated blood pressure (systolic > millimeters of mercury [mmHg] and/or diastolic > mmHg) despite medications. Patients who have uncontrolled hypertension (defined as sustained systolic blood pressure >= mmHg or diastolic >= mmHg) Uncontrolled hypertension (systolic blood pressure [sBP] > mmHg and/or diastolic BP > mmHg, found on two consecutive measurements separated by a one week period of time despite adequate medical support) Patients with uncontrolled hypertension (>= / mmHg) are NOT eligible for participation Significant uncontrolled pulmonary hypertension defined as: Pulmonary artery peak systolic pressure > mmHg by echocardiogram, or pulmonary artery peak systolic pressure - mmHg by echocardiogram and mean pulmonary artery pressure by right heart catheterization exceeding mmHg at rest (or mmHg with exercise); or NYHA/World Health Organization (WHO), Class III or IV Uncontrolled hypertension defined as systolic greater than and diastolic greater than . Uncontrolled hypertension (diastolic ? mmHg) or hypotension (systolic ? mmHg). Uncontrolled hypertension, defined as SBP ? mmHg and/or DBP ? mmHg with optimized anti-hypertensive therapy Known history of malignant hypertension (severe hypertension >/ mmHg with end organ involvement. Uncontrolled hypertension (diastolic greater to or equal to mmHg) or hypotension (systolic less than or equal to mmHg) Patients who have uncontrolled hypertension (defined as sustained systolic blood pressure >= mmHg or diastolic >= mmHg) Patients with uncontrolled hypertension (systolic > , diastolic > ) despite antihypertensive therapy No uncontrolled hypertension (systolic blood pressure =< millimeters of mercury [mmHg] or diastolic =< mmHg); patients with hypertension must be adequately controlled with appropriate anti-hypertensive therapy or diet Severe untreated resting arterial hypertension (> mmHg systolic, > mmHg diastolic) at the time of enrollment Uncontrolled hypertension (defined as consecutive readings over the past year of over systolic, and over diastolic) Uncontrolled arterial hypertension (systolic blood pressure > mmHg, diastolic > mmHg) Uncontrolled severe hypertension (systolic > mmHg or diastolic > mmHg) Subjects who have diabetes or uncontrolled hypertension are not eligible; NOTE: for the purposes of this study, uncontrolled will be defined as diastolic pressure over mmHg Uncontrolled hypertension (mmHg > systolic or > diastolic)