Patients status post a negative lymph node dissection are not eligible
Pathologically proven to be lymph node negative by pelvic lymphadenectomy (pN) or lymph node status pathologically unknown (undissected pelvic lymph nodes [pNx])
Patients must have undergone radical hysterectomy (open, laparoscopically or robotic) and staging including pelvic node sampling or dissection for cervical carcinoma within  days prior to study entry (NOTE: if the patient did not have a para-aortic lymph node sampling/dissection, but had common iliac node dissection that was negative, a positron emission tomography [PET]-computed tomography [CT] is recommended, but not required; a negative pre or post-operative PET scan or PET-CT scan of the paraaortic nodes is required if the patient did not undergo para-aortic or common iliac nodal sampling/dissection)
Number of allowable metastases:\r\n* =<  metastases seen on standard imaging within  days prior to registration when all metastatic disease is located within the following sites:\r\n** Peripheral lung \r\n** Osseous (bone)\r\n** Spine\r\n** Central lung\r\n** Abdominal-pelvic metastases (lymph node/adrenal gland)\r\n** Liver\r\n** Mediastinal/cervical lymph node
Subject meets one of the following criteria:\r\n* Evidence of active TLS during screening\r\n* A measurable lymph node with diameter >=  cm, or\r\n* A measurable lymph node with diameter >=  cm and an absolute lymphocyte count (including atypical lymphocytes and circulating lymphoma cells) >=  x ^/L
Histologically confirmed MCC metastases in clinically detected lymph node(s)\r\n* Confirmation of the MCC diagnosis in the clinically suspicious lymph node(s) is mandatory for trial participation\r\n* Subjects must have had clinically-detected (i.e. either palpable or radiologically abnormal) lymph nodal metastasis\r\n* (NOTE: In-transit metastases without regional nodal involvement could be allowed, but only after written approval of the medical monitor)
Suspicion or known history of distant metastatic MCC, which is not classifiable as local recurrence or regional metastasis\r\n* (NOTE: Patients presenting with nodal metastases in one lymph node basin and no known primary tumor are allowed to enroll)
Must be willing to undergo an incisional, excisional, or core needle lymph node or tissue biopsy or provide a lymph node or tissue biopsy from the most recent available archival tissue.
Unresectable ICC, with less than % of the liver involved, and without clinically significant extra-hepatic disease (regional lymph node lesions [?  cm] are acceptable) based on CT
Must have one of the following risk factors:\r\n* Lymph node >  cm\r\n*  or more positive lymph nodes\r\n* Perineural invasion\r\n* Lymphovascular space invasion\r\n* T or primary disease\r\n* Lymph node extracapsular extension
Gross tumor (primary tumor or involved lymph node) must be within  cm of esophagus on the most recent chest CT scan
Progressive lymphadenopathy including bulky disease as defined by mass, lymph node or lymph node cluster >  cm.
Patients must have at least one axillary and/or inguinal lymph node basin that is intact (no prior excisional biopsy of a node or complete lymph node dissection).
Lymph node only metastases even if considered M disease by official staging criteria.
Malignant, measurable lymph node is defined as a lymph node that must be >=  mm in short axis when assessed by CT scan
Clinical stage Ma (distant lymph node positive), or Mb (bone metastasis)
Pathology review at MD Anderson Cancer Center. The volume of disease must be high enough for the surgeon to agree to include an extended template pelvic lymph node dissection
Patients who have p negative squamous cell carcinoma of unknown primary in cervical lymph node
Lumpectomy with negative lymph node on surgical evaluation (isolated tumor cells in lymph nodes will be permitted); patients with invasive carcinoma >=  yrs and with estrogen receptor (ER)+ positive tumor =< . cm may enroll without surgical lymph node evaluation; patients with ductal carcinoma in situ (DCIS) of the breast only may enroll without surgical lymph node evaluation
Bladder cancer that was muscle invasive or positive for lymph node or distant metastasis
Pathologic or imaging evidence of lymph node involvement
All patients must have lymph node evaluation of contralateral stations  and/or  to exclude N disease
Subjects must not have presence of histologically proven lymph node disease
Patients with extra-pulmonary metastases aside from lymph node involvement or with a surgically unresectable primary lesion
No complete surgical resection for a head and neck cancer within  weeks of enrollment (although lymph node biopsy including excision of an individual node with presence of residual nodal disease, or surgical biopsy/excision of the tumor with residual disease is acceptable)
The primary tumor or lymph node must be readily biopsied by surgery or radiology teams
Patient must be willing to undergo additional biopsy of breast tumor or lymph node
If there is borderline lymphadenopathy, defined as the largest retroperitoneal lymph node measuring . - . cm in the greatest dimension, an abdominal computed tomography (CT) scan should be repeated (recommend interval of  -  weeks); the same lymph node must demonstrate growth to >= . cm in the greatest dimension
Histopathologically confirmed melanoma with an injectable cutaneous or lymph node metastasis that has progressed in the opinion of the treating investigator despite administering a Food and Drug Administration (FDA) approved anti-PD agent, with or without ipilimumab.
Presence of known lymph node involvement or distant metastases
Pathologic or clinical evidence for a stage Nb, Nb, or Nc breast cancer (supraclavicular, or internal mammary lymph node involvement)
Patients with previous inguinal lymph node dissection, radiosurgery, brachytherapy, or radiolabeled monoclonal antibodies
All treated patients have the option to undergo pre-treatment biopsy (liver, omentum, lung or lymph node) to be eligible
Have measurable disease based on Response Evaluation Criteria in Solid Tumors (RECIST) . including at least two tumor lesions that meet criteria for multi-organ site ablative radiation therapy (MOSART) SBRT radiation\r\n* . cc to  cc of viable tumor (i.e. primary disease or metastases) approximately  cm in maximal dimension; tumors larger than  cc can be partially treated\r\n* Metastases located in lung, liver, mediastinal/cervical node, spinal/paraspinal, osseous, abdominal-pelvic (lymph node/adrenal gland)
Prior inguinal lymph node dissection
Malignant melanoma present in an inguinal nodal basin requiring superficial inguinal lymph node (LN) dissection
Clinical or radiographic evidence of superficial inguinal LN disease or a prior positive sentinel lymph node (SLN) biopsy of the superficial inguinal basin as an indication for superficial inguinal lymph node disease is acceptable
Prior ipsilateral superficial inguinal lymph node dissection
Rectal cancer originally staged as T, T, or T, node negative (N) or node positive (N, N) by pelvic magnetic resonance imaging (MRI)
Surgery must have included a hysterectomy and bilateral salpingooophorectomy. Pelvic lymph node sampling and para-aortic lymph node sampling are optional.
N patients are ineligible, as are those with lymph node (LN) enlargement > . cm by CT or MRI of the pelvis, unless the LN is biopsy proven to be negative
Patients are eligible for this trial either at presentation for primary melanoma with concurrent regional nodal and/or in-transit metastasis, or at the time of clinically detected nodal and/or in-transit recurrence and may belong to any of the following groups:\r\n* Primary melanoma with clinically apparent (overt) regional lymph node metastases\r\n* Clinically detected recurrence of melanoma at the proximal regional lymph node(s) basin\r\n* Clinically detected primary melanoma involving multiple regional nodal groups\r\n* Clinically detected single site of nodal metastatic melanoma arising from an unknown primary\r\n* Patients with intransit or satellite metastases with or without lymph node involvement are allowed if they are considered potentially surgically resectable at baseline\r\n** NOTE: a patient should be determined to be potentially surgically resectable at baseline to be eligible for this neoadjuvant study
Regional lymph node involvement
Extensive extra hepatic spread of hepatocellular carcinoma; patients with limited metastatic disease may be enrolled as defined as;\r\n* Lymph node disease \r\n* Pulmonary nodules <  mm in size \r\n* - bone metastases
No pre-operative evidence of cervical lymph node metastases on neck ultrasound (Randomization arms ONLY)
Patients status-post a negative lymph node dissection are not eligible
Surgical staging to include total hysterectomy, +/- removal of ovaries and fallopian tubes, +/- lymph node sampling
Regional lymph node involvement
Evidence of extent of pancreatic cancer beyond that defined as \borderline resectable\ above (locally advanced or distant disease); peripancreatic lymph node involvement, either confirmed or suspected, will not be considered distant disease unless the lymph node involvement extends outside of the field of resection
Risk of malignant lymph node involvement < % as calculated on Partin tables
Risk of malignant lymph node involvement > % as calculated on Partin tables
All patients must have thorough tumor staging and meet at least one of the following criteria:\r\n* Either lymph node biopsy or lymph node dissection demonstrating lymph node metastasis by prostate cancer\r\n* Non-bulky (<  cm) regional pelvic or distant lymphadenopathy visualized on computed tomography (CT)/magnetic resonance imaging (MRI) scan; lymph node biopsy is required if < . cm or in atypical distribution\r\n* Primary tumor Gleason score >=  and serum prostate-specific antigen (PSA) concentration >=  ng/mL, indicating high risk of occult lymph node metastases\r\n* Primary clinical tumor stage of T and Gleason score >= , indicating high risk of occult lymph node metastases\r\n* Primary tumor stage T, indicating high risk of occult lymph node metastases; patients in any of these groups and less than  sites of non-predominantly lytic bone metastasis will be still considered eligible for the trial; the  American Joint Committee on Cancer (AJCC) staging system will be followed
Clinical stages Ta-Tb N M (American Joint Committee on Cancer [AJCC] Criteria th Ed.); for any pelvic lymph node >= .cm, biopsy of the lymph node is suggested
Evidence of lymph node involvement
History and/or clinical evidence of lymph node involvement (N)
Radiation and/or surgery (except lymph node or other diagnostic biopsies) within  days prior to day  of protocol therapy
Enlarged lymph node and/or clip targetable with image guidance
Has bulky tumor (define as N lymph node or equivalent lymph conglomerate (>=  cm in one dimension), or primary tumor >  cm); cystic HPV+ lymph nodes should be assessed in tumor board and may not be considered bulky
Patients who will undergo surgical treatment with either segmental resection or total mastectomy with lymph node evaluation
Successful removal of melanoma-draining lymph node (MDLN)
Breast imaging should include imaging of the ipsilateral axilla; for subjects with a clinically positive axilla by physical examination or clearly positive by imaging, axillary tissue acquisition is not required; for patients with a clinically negative axilla by examination and imaging, tissue acquisition is not required; for equivocal imaging findings, tissue acquisition (a needle aspiration, core biopsy) is required; sentinel lymph node (SLN) biopsy before neoadjuvant therapy is not allowed;\r\n* For a positive lymph node status by imaging and positive lymph node status by physical exam, a lymph node (LN) sampling not required but can be performed per physician discretion\r\n* For a positive lymph node status by imaging and negative lymph node status by physical exam, a LN sampling required\r\n* For a negative lymph node status by imaging and positive lymph node status by physical exam, a LN sampling required\r\n* For a negative lymph node status by imaging and negative lymph node status by physical exam, a LN sampling not required\r\n** Participants with axillary adenopathy only are not eligible for this study
Patients with disease recurrence after adequate surgical excision of the original primary cutaneous/unknown primary melanoma are allowed even if they dont fit the strict staging criteria, but only as follows:\r\n* Recurrence in a regional lymph node basin after a prior complete lymph node dissection; relapsed disease must be completely surgically resected with free margins\r\n* Recurrence in the form of in-transit or satellite metastases or distant skin/subcutaneous, nodal, or lung metastases that are completely surgically resected with free margins\r\n* Recurrence in a regional lymph node basin; relapsed disease must be completely surgically resected with free margins
Lymph node biopsy must be done < days prior to registration if used as an\n                  eligibility criterion for study entry.
Tumor or lymph node masses >  cm
Stage:\r\n* any T, N (i.e. a palpable mobile unilateral inguinal lymph node), M, or;\r\n* any T, N (i.e. palpable mobile multiple or bilateral inguinal lymph nodes), M, or;\r\n* any T, N (i.e. fixed inguinal nodal mass or any pelvic lymphadenopathy), M
Evidence (including Baseline MRI and bone scan) of extracapsular extension, sphincter involvement, seminal vesicle invasion, lymph node invasion or metastases
Clinical or pathological lymph node involvement (N)
Node positive disease (N or N) as designated in American Joint Committee on Cancer (AJCC) version ; either at least one pathologically confirmed positive lymph node or NC (defined as tumor deposit(s) in the subserosa, mesentery, or nonperitonealized pericolic or perirectal tissues without regional lymph node metastases); patients with resected stage IV disease are not eligible
No evidence of residual involved lymph node disease or metastatic disease at the time of registration
One of the following pathologic N-classifications: pN, pNX\r\n* If a lymph node dissection is performed, the number of lymph nodes removed per side of the pelvis and the extent of the pelvic lymph node dissection (obturator versus (vs.) extended lymph node dissection) should be noted whenever possible
More than three lesions per organ for visceral metastases except for lung or lymph node sites
Recent major surgery within  weeks prior to Cycle , Day , other than superficial lymph node biopsies for diagnosis
All patients must have lymph node evaluation of contralateral stations  and/or  to exclude N disease
Patient requires regional lymph node irradiation therapy
History of or current clinical, radiographic, or pathologic evidence of recurrent lymph node involvement after resection of a primary melanoma with lymph node involvement at any time in the past
Any node-negative tumor
Evidence for seminal vesicle/lymph node involvement of cancer.
If radiologic evaluation of a lymph node is interpreted as positive, this must be evaluated further either by lymphadenectomy or by percutaneous needle biopsy; patients with histologically or cytologically confirmed node metastases will not be eligible
Lymph Node Cancer Stage: N
Patient has undergone surgery on a separate occasion to clear the lymph nodes of the probable draining lymphatic field, including sentinel lymph node biopsy, of the index melanoma.
Patients are not permitted to have had any other conventional therapeutic intervention other than steroids prior to enrollment outside of standard of care chemotherapy and radiation therapy; patients who receive previous inguinal lymph node dissection, radiosurgery, brachytherapy, or radiolabeled monoclonal antibodies will be excluded
The primary and nodal involvement must be assessable on clinical exam (mucosal and lymph node exam)
No surgical resection for a head and neck cancer within  weeks of enrollment (although lymph node biopsy including excision of an individual node with presence of residual nodal disease, or surgical biopsy of the tumor is acceptable)
Palpable lymph node ?. cm in diameter (unless the lymph node has been biopsied and designated as Stage IA-IIA disease)
Residual invasive disease in the breast measuring at least cm with any lymph node involvement (does not include metastases in lymph node which are only detected by immunohistochemistry).
Must have one of the following risk factors:\r\n* Lymph node >  cm\r\n*  or more positive lymph nodes\r\n* Perineural invasion\r\n* Lymphovascular space invasion\r\n* T or microscopic Ta primary disease\r\n* Lymph node extracapsular extension
Patients must have biopsy-proven cyclin-dependent kinase inhibitor A (p)+ oropharynx cancer; the histologic evidence of invasive squamous cell carcinoma may have been obtained from the primary tumor or metastatic lymph node; it is required that patients have a positive p immunohistochemistry (IHC) (as surrogate for HPV) status from either the primary tumor or metastatic lymph node
Histopathologic assessment of surgical pathology must include examination for perineural invasion (PNI) and lymphovascular invasion (LVI) and reported as absent or present; the absence or presence of extracapsular extension (ECE) requires gross and microscopic assessment and is defined to be:\r\n* Absent (negative or nodal metastasis with smooth/rounded leading edge confined to thickened capsule/pseudocapsule),\r\n* Present - minimal (tumor extends =<  mm beyond the lymph node capsule), or\r\n* Present - extensive (gross, tumor extends >  mm beyond the lymph node capsule [includes soft tissue metastasis])
Patient must have metastasis at one or more of the following sites: bone, liver, lymph node and/or lung; no more than five lesions will be treated
Tumor  lymph node  (TN) disease or TN disease
Histologic diagnosis of melanoma belonging to the following American Joint Committee on Cancer (AJCC) primary tumor, lymph node, metastasis (TNM) stages:\r\n* Tx or T- and\r\n* Nb, or Nb, or Nc, or N and\r\n* M  \r\n* That may present as any of the following groups:\r\n** Primary melanoma with clinically apparent (overt) regional lymph node metastases, confirmed by pathological diagnosis (biopsy)\r\n** Clinically detected recurrence of melanoma at the proximal regional lymph node(s) basin, confirmed by pathological diagnosis (biopsy)\r\n** Clinically or histologically detected primary melanoma involving multiple regional nodal groups, confirmed by pathological diagnosis (biopsy)\r\n** Clinically detected single site of nodal metastatic melanoma arising from an unknown primary, confirmed by pathological diagnosis (biopsy)\r\n** Patients with intransit or satellite metastases with or without lymph node involvement are allowed if they are considered surgically resectable at baseline by the treating medical oncologist and surgical oncologist\r\n* NOTE: all patients must be determined to be surgically resectable at baseline to be eligible for this neoadjuvant study
Pelvic lymph node dissection for the diagnosis of seminoma
Indication for lymph node radiation (i.e. evidence of lymph node [LN] metastases)
Major surgery (excluding lymph node biopsy) within  days prior to signing informed consent.
Women with FDG PET positive high common or paraaortic lymph node metastasis confirmed by biopsy
Patients must have histologically confirmed, unresected cancer of the pancreas or ampulla; the cancer may include any invasive histology (e.g. adenocarcinoma, neuroendocrine carcinoma); patients with lymph node involvement or distant metastasis may be included if it is felt that local control of the primary site of disease would help reduce, or prevent the development of, local symptoms
Patients must have completed local therapy by surgery and/or ablative radiation therapy at least  months prior to entry, with removal or ablation of all visible disease, including seminal vesical and/or local lymph node involvement
Histologically documented melanoma with local lymph node stage III metastases
There must be plans for the cystectomy and lymph node dissection (LND) to be performed within  calendar days following registration; laparoscopic surgery is not allowed
Patients must not have intra-operative evidence of pelvic lymph node involvement (confirmed by frozen section) at or above the bifurcation of the common iliac vessels in any of the extended template
The participant must have axillary lymph node involvement by tumor and have one of the following indicating a higher risk of relapse:
Participants must be willing to undergo an incisional or excisional lymph node or tissue biopsy or provide a lymph node or tissue biopsy from the most recent available archival tissue.
Any lymph node with histologic extracapsular extension (ECS)
Patients with pancoast tumors, supraclavicular, or contralateral hilar lymph node involvement will be excluded if normal tissue constraints within the tolerance limits cannot be achieved at a dose per fraction of .- Gy to a total dose of  Gy
Patients must be women with a histologically confirmed diagnosis of breast cancer that is more than  cm and or lymph node positive
High risk of breast cancer recurrence, defined as documented evidence of one or more of the following criteria: i) Biopsy evidence of breast cancer in regional lymph node(s) LN (node- positive disease) Nodal micrometastases only are not considered node positive ii) Tumor size > cm (T) or locally advanced disease (T)
Regional lymph node involvement
The patient must have imaging documenting a primary tumor, or involved lymph node, >= . cm in greatest dimension
Histologic or cytologic diagnosis of stage III non-small cell lung cancer; patients will need to meet the following criteria for stage IIIA or IIIB diagnosis:\r\n* IIIA\r\n** Histologic or cytologic diagnosis of ipsilateral mediastinal lymph node involvement, or\r\n** Tumors greater than  cm or with chest wall invasion, or involvement of one of the following diaphragm, phrenic nerve, mediastinal pleura or parietal pericardium with hilar or mediastinal lymph node involvement\r\n** More than one mediastinal lymph node enlarged on computed tomography (CT) scan and the same lymph nodes positive on positron emission tomography (PET) scans or\r\n** Paralyzed left vocal cord with separate lung primary distinct from the aorto-pulmonary lymph nodes on the CT scan\r\n* IIIB\r\n** Histologic or cytologic diagnosis of N lymph node involvement; or\r\n** Enlarged N lymph nodes on CT scan that are positive on PET scan as well; patient must not have extension of lymph node involvement to cervical lymph nodes other than supraclavicular lymph nodes; or\r\n** Right sided primary with left vocal cord paralysis; or\r\n** Evidence of tumor extension into the mediastinum and/or mediastinal structures either at the time of mediastinoscopy, bronchoscopy or on CT scans\r\n** Patients with a nodules in the same lung but no other areas of involvement\r\n** Patients with prior surgically resected stage I NSCLC who did not receive any adjuvant therapy, who now have stage IIIA or B NSCLC will be eligible
Patients may have lymph node positive or negative disease, as long as they have clinical or pathologic stage II or III breast cancer; patients may have the lymph nodes assessed by any method deemed appropriate by the treating physicians, including pre-neoadjuvant therapy sentinel lymph node biopsy
Histologic diagnosis of melanoma belonging to the following American Joint Committee on Cancer (AJCC) TNM stages:\r\n* Tx or T- and\r\n* Nb, or Nb, or Nc, or N and/or\r\n* M  or M (if considered surgically operable)\r\n** Patients are eligible for this trial either at presentation for primary melanoma with concurrent regional nodal and/or in-transit metastasis and/or distant metastasis, or at the time of clinically detected nodal and/or in-transit recurrence and/or distant metastasis and may belong to any of the following groups: \r\n** Primary melanoma with clinically apparent (overt) regional lymph node metastases\r\n** Clinically detected recurrence of melanoma at the proximal regional lymph node(s) basin\r\n** Clinically detected primary melanoma involving multiple regional nodal groups\r\n** Clinically detected site of nodal metastatic melanoma arising from an unknown primary\r\n** Patients with intransit or satellite metastases with or without lymph node involvement are allowed if they are considered surgically resectable at baseline\r\n** Patients with distant metastases with or without intransit or lymph node involvement are allowed if they are considered potentially surgically resectable at baseline\r\n** NOTE: All patients must be determined to be surgically resectable at baseline to be eligible for this neoadjuvant study
Diagnosis of urothelial carcinoma with stage T or greater disease without lymph node involvement where neoadjuvant chemotherapy of cisplatin and gemcitabine are indicated
Lymph node positive urothelial carcinoma
Subjects with FIGO Clinical Stage I endometrial cancer undergoing minimally invasive hysterectomy with lymph node mapping.
Any lymph node >  cm or multistation N lymphadenopathy
At least one enlarged lymph node that is considered accessible for percutaneous injection by the investigator and that is at least  cm in longest dimension
Lymphoma patients in which the delay of surgery until the lymph node resection date or other factors associated with the study are not feasible
Note: Skin, lymph node, or soft tissue involvement; carpal tunnel syndrome; or bone marrow amyloid as the sole clinical manifestations of amyloidosis are not sufficient for inclusion.
Participants with enlarged para-aortic lymph node involvement on imaging that is suspicious for metastasis
CD+ B cells in lymph node biopsy or other lymphoma pathology specimen.
Subjects must have provided written, informed consent prior to any study procedures: collection of blood and lymph node (LN) tissue specimens for this protocol
Patients must have histologically or cytologically confirmed prostate cancer with EXTENSIVE metastatic disease and have been on androgen deprivation therapy for <  days; hormonal therapy must not have commenced more than  days prior to study\r\n* Definition of extensive disease: Metastases involving at least one lesion in any bony structures beyond the vertebral column and pelvic bone or any involvement with viscera; in the absence of visceral lesion, there must be four or more bone lesions; patients with disease limited to vertebral column and/or pelvis alone with or without lymph mode or lymph node only disease involvement are not eligible for this trial
Patients who are required because of their disease to see primarily oncologists for follow-up will be excluded (i.e., those diagnosed with lymph node or distant metastasis, those with a new primary cancer)
The patient is a candidate for surgical intervention, with lymph node mapping being a part of the surgical plan
Lymph node-positive breast cancer or high-risk lymph node-negative breast cancer. The latter is defined by any one of the following criteria:
Node-positive disease
The patient is a candidate for surgical intervention, with lymph node dissection being a part of the surgical plan
Healthy adult patients who are undergoing LEFT modified radical or selective (including zone IV) lymph node dissection for any indication; this includes patients who have had prior neck surgery
No prior salvage therapies (including salvage radiotherapy and/or salvage lymph node dissection)
Planned prostatectomy with lymph node dissection
Planned prostatectomy with lymph node dissection
Subjects with known or suspected lung cancer with mediastinal adenopathy as defined by a mediastinal lymph node > . cm in short axis on EBUS or any lymph node with uptake on fludeoxyglucose F- (FDG)-positron emission tomography (PET) scan that is higher than background PET activity
Planned prostatectomy with lymph node dissection
Radiographic evidence of at least one bone, lymph node, or liver metastasis, that is amenable to iodinated contrast injection, as judged by the study radiologist
Patient with indications for mediastinal lymph node (LN) sampling per th American College of Clinical Pharmacy (ACCP) guidelines
Planned prostatectomy with lymph node dissection
Node positive
Planned prostatectomy with lymph node dissection
Lymph node not amenable to core biopsy
Patient is unlikely to undergo lymph node excision (i.e. elderly patient)
Any patient who has bilateral lymph node mapping or dissection
Subject has been diagnosed with melanoma, rhabdomyosarcoma, or other tumor where tumor resection or biopsy is planned and lymph node mapping is appropriate
Has had previous surgery or radiation to node basins that would be involved in the intraoperative lymph node mapping (ILM) procedure
Be scheduled for staging endoscopic ultrasound with the intent for lymph node evaluation.
Subjects with known or suspected lung cancer with mediastinal adenopathy as defined by a mediastinal lymph node >  cm in short axis or a normal sized lymph node with uptake on fludeoxyglucose (FDG)-positron emission tomography (PET) scan that is higher than background PET activity
Patients in which only one lymph node station is expected to be sampled by the performing clinician
Metastatic disease on standard staging imaging (beyond regional lymph node involvement)\r\n* Absence of metastatic disease (beyond regional lymph node involvement) as defined by a negative bone scan, NaF PET, CT chest/abdomen/pelvis, or total body MRI
Has cervical cancer and is a candidate for surgical intervention, with lymph node dissection being a part of the surgical plan.
Patients referred for EUS-guided tissue acquisition because of a (I) pancreatic mass lesion or (II) lymph node
Subject has a clinical negative node status (i.e. T-, N, M).
Patients with a new diagnosis of soft tissue sarcoma, with a clinically palpable or radiographically concerning node (>  mm, positron emission tomography [PET] avid, or of unusual shape on any imaging modality) who will undergo lymph node biopsy (sentinel node biopsy, dissection, lymph node sampling etc); these patients can be pediatric or adult patients
Prior chemotherapy or radiotherapy (to the lymph node basin)
Primary papillary thyroid cancer (PTC), which appears to be stage T or T on imaging or with macroscopic lymph node involvement AND requires surgical resection
Persistent or locally recurrent PTC with macroscopic lymph node involvement which requires surgical resection
No evidence of distant metastatic disease; patients with regional lymph node involvement are eligible
Will have administration of methylene blue or any blue dye for sentinel lymph node mapping on the day of the surgery prior to imaging the lumpectomy cavity with the LUM Imaging Device.
Medical conditions and/or prior surgical procedures that have the potential to substantially alter the lymphatic drainage pattern from the primary tumor to the lymph node basin.
Inability to localize  or  lymph node drainage basin(s) via lymphatic mapping.
Women with node negative disease
Patients with clinically detected or suspicious lymph node involvement not readily amenable to surgical treatment (>= cN disease)