Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents while on study Patients may not be receiving any other investigational agents while on study Patients must not be receiving or planning to receive any other investigational agents Patients may not be receiving any other investigational agents while on study treatment Patients receiving ongoing treatment with any other investigational agents are not eligible Patients may not be receiving any other investigational agents Patients receiving any other investigational agents are ineligible Patients receiving any other investigational agents are excluded EXCLUSION CRITERIA FOR THIRD-LINE THERAPY: Patients receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients receiving ongoing treatment with any other investigational agents are not eligible Patients who are receiving any other investigational agents Patients receiving any other investigational agents. Patients must not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational therapy Patients who are receiving any other investigational agents Patients receiving any other investigational agents are excluded Patients receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other therapeutic investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents for treatment of their kidney cancer Patients who are receiving other investigational agents Patients who are actively receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents or other tumor-directed therapy. Patients who are receiving any other investigational agents Patients receiving other investigational agents. Patients who are receiving any other investigational agents. Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents. Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents for the treatment of their breast cancer Patients who are receiving any other investigational agents Patients receiving any other investigational agents are ineligible Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients must not be receiving any other investigational agents Patients may not be receiving any other investigational agents within days of registration Patients must not be receiving any other investigational agents Patients receiving other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents. Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents. Patients who are receiving any other investigational agents. Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents =< days prior to study treatment Patients who are receiving any other investigational agents Patients receiving any other investigational agents Patients who are receiving any other investigational agents Patients receiving other investigational agents Patients receiving any other investigational agents Patients who are receiving any investigational agents Patients who are receiving any other investigational agents or other tumor-directed therapy Patients receiving any other investigational agents Patients who are receiving any other investigational agents within days before start of study treatment Patients may not be receiving any other investigational agents =< days from registration Patients who are receiving any other investigational agents or have within the last days Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents are ineligible Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents (with exception of imaging agents) Patients who are receiving any other investigational agents; however, prior enrollment on a study using investigational agents is acceptable Patients who are receiving any other investigational agents within the preceding weeks Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients receiving any other investigational agents Patients receiving any investigational agents Patients receiving any other investigational agents Patients receiving any other investigational agents or immunotherapy Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents within the preceding weeks Patients who are receiving any investigational agents Patients who are receiving any investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents. Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational therapeutic agents Patients who are receiving other investigational therapeutic agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients receiving any other investigational agents. Patients may not be receiving any other investigational agents Patients receiving any other investigational agents Patients may not be receiving any other investigational agents and/or other therapy for their cancer Patients may not be receiving any other investigational cancer treatment agents at the time of enrollment Patients who are receiving any other investigational agents Patients receiving any other study agents Patients who are receiving any other investigational agents EXCLUSION CRITERIA FOR REGISTRATION: patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients receiving any other investigational agents are ineligible Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients receiving any other investigational agents are ineligible Patients receiving any other investigational agents Patients may not be receiving any other investigational agents TUMOR BIOPSY SEQUENCING: Patients who are receiving any other investigational agents; patients on other trials will be eligible as long as they are no longer receiving study treatment TREATMENT: Patients who are receiving any other investigational agents; patients on other trials will be eligible as long as they are no longer receiving study treatment Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients must not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients receiving any other investigational agents Patients who are receiving any other biologic, cytotoxic or investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients receiving any other investigational agents or patients that have received other investigational agents within days of enrollment Patients receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients receiving any other investigational agents are ineligible Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any additional investigational agents or radiation therapy Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents for melanoma Patients who are receiving any other investigational agents Patients receiving any other investigational agents or patients that have received other investigational agents within days of enrollment Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents are not eligible Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents PHASE II: Patients may not be receiving any other investigational agents while on study Patients must not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents for cancer Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients must not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients receiving any other investigational agents or patients that have received other investigational agents within days of enrollment Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients must not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents within weeks prior to registration Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational cancer-directed agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients receiving other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients receiving any other investigational agents or patients that have received other investigational agents within days of enrollment Patients may not be on any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients should not be receiving any other investigational agents Ongoing therapy with other investigational agents. Patients may not be receiving any other investigational agents. Patients who are receiving any other investigational agents Patients receiving any other investigational agents for cancer treatment Patients may not be receiving any other investigational agents while on study treatment Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents while on study Patients who are receiving any investigational agents Patients who are receiving any investigational agents. Patients may not be receiving any other investigational agents Patients receiving any other chemotherapy or investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents. Patients receiving any other investigational agents Patients receiving other investigational agents Patients may not be receiving any other investigational agents Patients should not be receiving any other investigational agents Patients should not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents. Patients receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents or other medications for the treatment of their malignancy Patients receiving any other investigational agents Patients receiving any other investigational agents are ineligible Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents or have received immunotherapy Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients receiving any other investigational agents or patients that have received other investigational agents within days of enrollment Patients may not be receiving any additional investigational agents or radiation therapy Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents within days before start of study treatment Patients should not be receiving any other investigational agents Patients may not be receiving any investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents. Patients receiving any other investigational agents are ineligible Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients receiving any other investigational agents Patients may not be receiving any other investigational agents Patients receiving any other investigational agents Patients who are receiving any other investigational agents Patients planning on receiving other investigational agents while on this study Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents or have received other investigational agents for at least weeks Patients who are receiving any other investigational agents Patients may not be receiving any other investigational agents within days of registration Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients who are receiving any other investigational agents Patients receiving any other investigational agents are ineligible Patients receiving any other study agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients receiving any other investigational agents are ineligible Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients may not be receiving any other investigational agents Patients receiving any other study agents Patients who are receiving any other investigational agents Patients receiving any other investigational agents within weeks of starting the study Patients may not be receiving any other investigational agents Patients who are receiving any other investigational agents Patients receiving Patients who are receiving any other investigational agents