Within days prior to registration: Creatinine =< . x institutional upper limit of normal (ULN) Creatinine =< . x institutional upper limit of normal within weeks before randomization Serum creatinine =< . x institutional upper limit of normal (ULN), measured within days prior to administration of study treatment Serum creatinine =< . x institutional upper limit of normal (ULN) OR Creatinine within less than the institutional upper limit of normal Creatinine =< . X the institutional upper limit of normal (ULN) Creatinine less than or equal to . x institutional upper limit of normal (ULN), equivalent to the active version of the NCI adverse event (AE) grade Obtained within days prior to registration: Creatinine =< . x the institutional upper limit of normal (ULN) Serum Creatinine ?. institutional upper limit of normal (ULN) Creatinine =< . x institutional upper limit of normal (ULN) Within days of randomization: Creatinine =< . x the institutional upper limit of normal (ULN) Serum creatinine =< x the institutional upper limit of normal. Creatinine =< . x institutional upper limit of normal (ULN), within weeks of registration Creatinine =< . x institutional upper limit of normal Serum creatinine =< upper limit of institutional normal Creatinine =< . x institutional upper limit of normal Serum creatinine level less than or equal to . x institutional upper limit normal (ULN) (CTCAE v. grade ) Phosphorus =< institutional upper limit of normal Creatinine =< . x institutional upper limit of normal (ULN) Creatinine =< . X institutional upper limit of normal Creatinine =< . x institutional upper limit of normal (ULN), within weeks of registration (except where specified otherwise) Creatinine < . X institutional upper limit of normal Creatinine =< . x institutional upper limit of normal Serum creatinine =< . x institutional upper limit of normal Creatinine =< . x institutional upper limit of normal Serum creatinine =< . X institutional upper limit of normal (ULN) PHASE I: Creatinine < . x the institutional upper limit of normal (ULN) Serum creatinine =< . X institutional upper limit of normal (ULN) (measured within days prior to administration of study treatment) Creatinine less than or equal to . x institutional upper limit of normal (ULN), CTCAE version grade Creatinine =< . x institutional upper limit of normal Serum creatinine less than or equal to . x institutional upper limit of normal for age Creatinine =< . x upper limit of institutional normal (ULN) Creatinine =< . x institutional upper limit of normal Creatinine less than or equal to . x institutional upper limit of normal (ULN) Serum creatinine =< . x the institutional upper limit of normal Patients must have adequate hepatic function as documented by a bilirubin ? x the institutional upper limit of normal, an alkaline phosphatase ? x the institutional upper limit of normal, and an SGOT and SGPT ? x the institutional upper limit of normal all obtained within days prior to enrollment. Creatinine =< . X institutional upper limit of normal (ULN) Serum creatinine =< . x institutional upper limit of normal (IULN) Patients must have normal organ function as defined below:\r\n* Serum creatinine < . x institutional upper limit of normal (ULN)\r\n* International normalized ratio (INR) < . x institutional ULN Creatinine =< institutional upper limit of normal Creatinine =< . mg/dL for patients over years or =< . x institutional upper limit of normal (ULN) for age, measured prior to conditioning chemotherapy Creatinine =< institutional upper limit of normal OR Creatinine: < . x institutional upper limit of normal Renal function: creatinine ? . x institutional upper limit of normal (ULN); Creatinine =< . X institutional upper limit of normal Creatinine =< X institutional upper limit of normal Creatinine =< . x institutional upper limit of normal Serum creatinine =< . x upper limit of institutional normal Creatinine =< institutional upper limit of normal OR Serum creatinine =< . x institutional upper limit of normal Note: ULN is institutional or laboratory upper limit of normal Creatinine =< . mg/dL x the institutional upper limit of normal Secondary Registration: serum creatinine =< . x institutional upper limit of normal Serum creatinine =< . x institutional upper limit of normal Subjects must have normal organ and marrow function as defined below:\n\n . Absolute neutrophil count ? /cmm\n\n . Platelets ? ,/cmm\n\n . Total bilirubinwithin normal limits of the institution\n\n . AST/ALT ? . X institutional upper limit of normal (ULN) or ? X institutional\n upper limit of normal (ULN) in the presence of liver metastases\n\n . Creatinine ? . X institutional upper limit of normal (ULN) Serum creatinine < . x the institutional upper limit of normal Creatinine =< X institutional upper limit of normal Creatinine =< . x institutional upper limit of normal Creatinine =< . X institutional upper limit of normal OR Serum creatinine =< the institutional upper limit of normal Creatinine < . x institutional upper limit of normal OR Serum creatinine =< . x institutional upper limit of normal (ULN), measured within days prior to administration of study treatment Regimens I and II: Creatinine =< . x institutional upper limit normal (ULN), CTCAE grade \r\n* Regimen III: Creatinine no greater than the institutional upper limits of normal Creatinine (non-isotope dilution mass spectrometry [IDMS]) =< . x institutional upper limit normal (ULN), CTCAE grade Serum creatinine < . X upper limit of normal (ULN) (institutional) Creatinine less than or equal to . x institutional upper limit of normal (ULN) Serum creatinine =< . mg/dL for patients over years or =< . x institutional upper limit of normal (ULN) for age Serum creatinine should be within normal limits as specified by institutional guidelines; for patients with serum creatinine > upper limit of normal, a -hour creatinine clearance will be performed and should be equal to or more than the lower limit of normal Creatinine =< . x institutional/laboratory upper limit of normal (ULN) Creatinine =< . x the institutional normal upper limit Creatinine =< . x institutional upper limit of normal Serum creatinine < . X institutional upper limit of normal Creatinine =< x institutional upper limit of normal if patient has chronic renal insufficiency and creatinine has been stable x > months Creatinine =< x institutional upper limit of normal Creatinine =< . x upper limit of normal (ULN); institutional norms are acceptable Serum creatinine =< . x the institutional upper limit of normal obtained within days prior to start of therapy Creatinine =< . x upper limit of normal (institutional ULN) Serum creatinine =< . X institutional upper limit of normal Creatinine =< . x institutional upper limit of normal OR Creatinine =< X institutional upper limit of normal Creatinine =< . x institutional upper limit of normal (ULN), CTCAE grade Creatinine =< X institutional upper limit of normal Serum creatinine =< . x institutional upper limit of normal (ULN), obtained within days prior to first treatment Patients must have normal organ and marrow function as defined below: leukocytes >,/mcL; absolute neutrophil count >,/mcL; platelets >,/mcL; total bilirubin <. X institutional upper limits of normal; AST(SGOT)/ALT(SGPT) <. X institutional upper limit of normal; Alkaline phosphatase (AP) <. X institutional upper limit of normal; creatinine <.X institutional upper limit of normal OR creatinine clearance > mL/min/. m for patients with creatinine levels above institutional normal Creatinine < . institutional upper limit of normal OR Serum creatinine concentration < X the institutional upper limit of normal (ULN) Creatinine less than or equal to . x institutional upper limit normal (ULN), CTCAE v. grade Creatinine =< . x institutional upper limit of normal Serum creatinine =< . the institutional upper limit of normal Creatinine =< . X institutional upper limit of normal Serum creatinine less than or equal to . x institutional upper limit normal (ULN) Creatinine =< . x upper limit of institutional normal for age Serum creatinine =< . X institutional upper limit of normal Creatinine =< x institutional upper limit of normal Creatinine =< . x institutional upper limit Serum creatinine < x institutional upper limit of normal OR LDH < . X institutional upper limit of normal Creatinine =< . x institutional upper limit of normal (ULN), CTCAE grade Creatinine < . x institutional upper limit of normal (ULN) Serum creatinine < institutional upper limit of normal (ULN) Creatinine =< institutional upper limit of normal (ULN) Serum creatinine within . x upper limit of institutional normal Creatinine =< . x institutional upper limit of normal (ULN) obtained =< days prior to randomization Creatinine =< . x institutional upper limit of normal Creatinine =< . x the institutional upper limit of normal (ULN), obtained within days prior to treatment start Creatinine =< institutional upper limit of normal OR Measured within days prior to administration of study treatment: Serum creatinine =< . x institutional upper limit of normal (ULN) Creatinine =< twice upper limit institutional normal Serum creatinine less than or equal to . x institutional upper limit normal (ULN) Creatinine =< . x the institutional upper limit of normal Serum ferritin < . X institutional upper limit of normal Serum ferritin < . X institutional upper limit of normal Serum creatinine =< institutional upper limit of normal (IULN) Significant history or current renal insufficiency (serum creatinine > . institutional upper limit of normal) Have a serum creatinine above . upper limit of normal (ULN) (collected within the past weeks); ULN is per institutional definition