Patients must have histologically confirmed invasive breast cancer with stage IV disease, either biopsy proven or with unequivocal evidence of metastatic disease by physical examination or radiological study Presence of metastatic disease (stage IV NSCLC) is not allowed; subjects must be evaluated with a CT or PET scan prior to registration for protocol therapy to exclude metastatic disease SAFETY RUN-IN: Disease stage: unresectable metastatic disease RANDOMIZED PHASE II CLINICAL TRIAL: Disease stage IV, metastatic unresectable disease Prior exposure to cetuximab in the metastatic (stage IV) setting Stage IV disease (metastatic or surgically unresectable, cTb, N+, or M+ cancer) Metastatic (stage IV) triple negative breast cancer that has progressed after at least one prior chemotherapy regimen in the metastatic setting; non-measurable disease (i.e. bone metastases) is permitted Stage IV metastatic disease with intracranial disease visible with magnetic resonance image (MRI) Patients with a history of stage IV or metastatic disease Patient has stage N or M (metastatic) disease Stage IV metastatic disease (only during the phase II) Patients who have received previous treatment for metastatic or stage IV disease Stage IV (metastatic) disease. Stage IV (metastatic) disease Patients with distant metastatic disease (stage IVC) Previously untreated stage III/IV advanced or metastatic MEL (Part C only) No stage IV (metastatic) disease, however no specific staging studies are required in the absence of symptoms or physical exam findings that would suggest distant disease. Presence of metastatic disease (stage IV NSCLC) is not allowed. Subjects must be evaluated with a PET scan within days prior to registration for protocol therapy to exclude metastatic disease Have metastatic disease (stage IV) confirmed surgically, by imaging or pathologically Evidence of metastatic disease (stage M) Patient presents with Stage pulmonary metastatic disease with metastatic disease previously confirmed by prior biopsy; or Patient presents with Stage pulmonary metastatic disease previously confirmed on imaging (e.g. computerized tomography or CT) with histology proven primary cancer. No stage IV (metastatic) disease, however no specific staging studies are required in the absence of symptoms or physical exam findings that would suggest distant disease. Patients with metastatic disease involving viscera or bones are ineligible; patients with extensive nodal involvement alone classified as stage IV disease, are eligible Metastatic (stage IV) disease (including involvement of the colon, adrenals, or kidney, or radiographic evidence of peritoneal seeding or pulmonary metastases) Patients with known brain metastases should be excluded as this would qualify as stage IV/metastatic disease Patients with histologically documented metastatic melanoma with:\r\n* (Metastatic disease cohort) measurable disease, stage IIIB, IIIC (in transit lesions with or without nodal metastases) that includes lesions accessible for biopsies or IV MB\r\n* (Adjuvant cohort) subjects who are no evidence of disease (NED) and stage III or IV; this includes patients with stage IV disease resected to NED; stage IIB or IIC patients will be enrolled after review and approval by the PI Metastatic disease (Stage IV) OR Newly diagnosed untreated stage IV and/or recurrent after adjuvant therapy with metastatic disease Advanced (FIGO stage III or IV), recurrent or metastatic disease. Initial presentation: stage IV or metastatic disease, enrolled prior to any cytoreductive therapy Inoperable or metastatic extra cranial stage III or IV disease Metastatic (stage IV) BCa Confirmed diagnosis of metastatic or stage IV BC Metastatic disease (Stage IV C) Staging to rule out metastatic disease is recommended for subjects with clinical stage III disease Has metastatic disease (M) Stage IV C Metastatic disease (Stage IV C) Stage IV or distant metastatic disease Subject has metastatic disease (M) Stage IV-C. Participants with known metastatic (stage IV) prostate cancer Patients with in situ cancers (Stage ) and those with metastatic disease (Stage IV); Stage IV cancer or evidence of metastatic disease at any time point