Subject has had major surgery within weeks prior to Cycle Day- (subjects must have completely recovered from any previous surgery prior Cycle Day-). Major surgery within days before Cycle Day Major surgery within days prior cycle , day Has had major surgery within days before cycle , day Participant had major surgery within days prior to Study Day . Subject has had major surgery within days prior to study day Major surgery within days of study day with the exception of biopsy and long line insertion Has had major surgery within days before cycle , day . Major surgery within weeks prior to study day (subjects must have completely recovered from any previous surgery prior to study day ) Major surgery or radiotherapy within days prior to Day of Cycle or anticipation of needing such procedure while receiving study treatment A minimum of weeks from any major surgery prior to cycle day Patients must have recovered from the effects of surgery; there must be a minimum of days from the day of surgery to the day of protocol treatment Major surgery within days prior to day of study treatment from which the patient has not completely recovered Patients who have had major surgery within days before cycle , day Has had major surgery within days before cycle , day Subject has had major surgery within days prior to study day Major surgery requiring a prolonged hospitalization or recovery within days before day of study drug Major surgery within four weeks before cycle day Systemic radiation therapy or major surgery < days prior to study Day as well as focal radiotherapy < days prior to study Day . Major surgery (as defined by the investigator) within the days prior to day of protocol therapy Planned major surgery during the study or within weeks of Cycle , Day Major surgery within weeks prior to study day (subjects must have completely recovered from any previous surgery prior to study day ) Major surgery within weeks prior to study day (patients must have recovered completely from any previous surgery prior to study day ). Subject has received prior therapy for cancer or major surgery within days, or days for nitrosourea or mitomycin C, prior to Cycle Day , or days for tamoxifen; Has had major surgery within days before cycle day Major surgery within days of study day Major surgery within days before Cycle Day Major surgery within weeks prior to study day (subjects must have completely recovered from any previous surgery prior to study day ) Patients with recent major surgery within days prior to cycle , day Major surgery within three weeks before cycle day Major surgery within days prior to the first day of treatment Received monoclonal antibodies or had major surgery within days of the first dose of brigatinib (Day , Cycle ). Major surgery or radiation therapy within weeks of cycle , day No major surgery within days and minor surgery within days prior to cycle day Major surgery within days of Day Major surgery within days and minor surgery within days prior to cycle day Has had major surgery (requiring at least a day hospital stay) in the past days Major surgery within days of study day Major surgery within weeks before cycle day Major surgery within days before day . Major surgery, chemotherapy, investigational agent, or radiation within days of Day Major surgery within days before Cycle Day Major surgery within days of study day Major surgery within days before Study Day ; Major surgery, chemotherapy, investigational agent, or radiation within days of Day Major surgery within days of study day Major surgery within four weeks before cycle , day Patient received radiation therapy or major surgery within one month of Cycle Day Have had major surgery within days prior to the start of Day ; Use of dexmedetomidine within days prior to day of surgery Major surgery within days of day of trial Major surgery within days before Cycle Day