History of malabsorption syndrome or other condition that would interfere with enteral absorption Active gastrointestinal disease or other malabsorption syndromes Malabsorption syndrome or other condition that would interfere with enteral absorption Subject has malabsorption syndrome or other condition which may affect an enteral route of administration Malabsorption syndrome or other condition that would interfere with enteral absorption Malabsorption syndrome or other conditions that preclude enteral route of administration History of malabsorption or other condition that would interfere with absorption of study drugs Malabsorption syndrome or other condition that precludes enteral route of administration Any malabsorption condition Malabsorption condition that would alter the absorption of orally administered medications History of malabsorption syndrome or other condition that would interfere with enteral absorption Malabsorption syndrome or other condition precluding enteral route of administration Any malabsorption condition Any malabsorption condition Malabsorption syndrome or other conditions that would interfere with intestinal absorption Any malabsorption condition History of known malabsorption syndrome or prior surgery(ies) that may lead to malabsorption Malabsorption syndrome or other condition that precludes oral route of administration of lenalidomide. Malabsorption syndrome or other condition that precludes enteral route of administration Subject has a malabsorption syndrome or other condition that precludes enteral route of administration Malabsorption syndrome or other condition that precludes enteral route of administration Malabsorption condition that would alter the absorption of orally administered medications Participant has a malabsorption syndrome or other condition that precludes enteral route of administration. History of malabsorption or other condition that would interfere with absorption of cobimetinib. History of malabsorption syndrome or other condition that would interfere with enteral absorption Malabsorption syndrome or other condition that precludes enteral route of administration Any malabsorption condition Participant has a malabsorption syndrome or other condition that precludes enteral route of administration. Any malabsorption condition malabsorption syndromes Malabsorption syndrome or other condition that precludes enteral route of administration Any malabsorption problem Patients must not have clinically significant malabsorption syndrome or history Malabsorption syndrome or other condition that precludes enteral route of administration History of malabsorption or other condition that would interfere with absorption of vemurafenib Malabsorption syndrome or other condition that precludes enteral route of administration Known or suspected malabsorption condition or obstruction Patients with hypercalcemia and/or any condition resulting in malabsorption Malabsorption syndrome or other condition that would interfere with intestinal absorption are excluded Any malabsorption condition. Participants with malabsorption syndrome or any other condition that precludes enteral administration. Known or suspected malabsorption condition or obstruction; Note: Use of pancreatic enzyme supplements is allowed to control malabsorption Malabsorption syndrome or other condition that precludes enteral route of administration Malabsorption syndrome or other conditions that preclude enteral route of administration Suspected malabsorption or obstruction; note: use of pancreatic enzyme supplements is allowed to control malabsorption Any malabsorption condition Malabsorption syndrome, such as Crohns disease Any malabsorption problem Any malabsorption condition Clinically significant malabsorption syndrome Known or suspected malabsorption condition or obstruction Clinically significant malabsorption syndrome Any malabsorption condition Malabsorption syndrome or other condition that would interfere with intestinal absorption Patients with malabsorption syndrome or other condition that would interfere with intestinal absorption Any malabsorption problem Any malabsorption condition Have malabsorption syndrome or other gastrointestinal (GI) illness or condition. Any malabsorption condition. Any malabsorption condition Any malabsorption condition. History of malabsorption syndrome or other condition that would interfere with enteral absorption Malabsorption syndrome or other condition that precludes enteral route of administration Any malabsorption condition Any malabsorption condition Any malabsorption condition Participant has a malabsorption syndrome or other condition that precludes enteral route of administration. Subject has malabsorption syndrome or other condition that precludes enteral route of administration Any malabsorption condition Any malabsorption condition Any malabsorption problem PHASE I: Clinically significant malabsorption syndrome Malabsorption syndrome or other condition that precludes enteral route of administration History of malabsorption syndrome or other condition that would interfere with enteral absorption Exclusion Criteria Related to Medications: Malabsorption syndrome or other conditions that would interfere with intestinal absorption Any malabsorption condition Any malabsorption condition Malabsorption problem that may limit or inhibit the absorption of MEK Any malabsorption condition Any malabsorption condition No known malabsorption syndrome Any malabsorption conditions History of malabsorption or other condition that would interfere with absorption of vemurafenib/cobimetinib A history of malabsorption or other condition that would interfere with absorption of vemurafenib or cobimetinib. History of malabsorption syndrome or other condition that would interfere with enteral absorption History of malabsorption or other condition that would interfere with enteral absorption Malabsorption syndrome or other condition that would interfere with enteric absorption Patients with uncontrolled malabsorption syndromes Any malabsorption condition Participants with malabsorption syndrome or any other condition that precludes enteral administration. History of malabsorption or other condition that would interfere with enteral absorption Malabsorption syndrome Malabsorption ; History of malabsorption syndrome or other condition that would interfere with enteral absorption Any malabsorption problem Any malabsorption problem Any malabsorption problem History of malabsorption syndrome or other condition that would interfere with enteral absorption Any malabsorption problem Malabsorption syndrome or other condition that would interfere with enteral absorption Any malabsorption disease/syndrome Clinically significant gastrointestinal malabsorption syndrome