Patients receiving any medications or substances that are inhibitors or inducers of CYPA, or CYPA substrates need to be reviewed by the principal investigator; continuation of such medications will be at the discretion of the principal investigator; concomitant use of aprepitant or fosaprepitant is prohibited; as grapefruit and Seville oranges are known to contain moderate inhibitors of CYPA, these fruits or their products (including marmalade, juice, etc.) should be avoided while taking AZD; the use of sensitive substrates of CYPA, such as atorvastatin, simvastatin and lovastatin, is also prohibited in this study; herbal preparations are not allowed throughout the study; these herbal medications include but are not limited to: St. John's wort, kava, ephedra (mahung), gingko biloba, dehydroepiandrosterone (DHEA), yohimbe, saw palmetto and ginseng
Patients who have taken herbal medications and certain fruits within  days prior to starting study drug; herbal medications include, but are not limited to St. Johns wort, Kava, ephedra (ma huang), Gingko biloba, dehydroepiandrosterone (DHEA), yohimbe, saw palmetto, and ginseng; fruits include the cytochrome P, family , subfamily A (CYPA) inhibitors Seville oranges, grapefruit, pummelos, or exotic citrus fruits
Patients who have taken herbal medications and certain fruits within  days prior to starting study drug; herbal medications include, but are not limited to St. Johns wort, Kava, ephedra (ma huang), gingko biloba, dehydroepiandrosterone (DHEA), yohimbe, saw palmetto, and ginseng; fruits include the CYPA inhibitors Seville oranges, grapefruit, pummelos, or exotic citrus fruits
Patients who have taken herbal medications and certain fruits within  days prior to starting study drug; herbal medications include, but are not limited to St. John's wort, kava, ephedra (ma huang), gingko biloba, dehydroepiandrosterone (DHEA), yohimbe, saw palmetto, and ginseng; fruits include the cytochrome P, family , subfamily A (CYPA) inhibitors Seville oranges, grapefruit, pummelos, or exotic citrus fruits
Patients who have taken herbal medications and certain fruits within  days prior to starting study drug; herbal medications include, but are not limited to St. Johns wort, Kava, ephedra (ma huang), gingko biloba, dehydroepiandrosterone (DHEA), yohimbe, saw palmetto, and ginseng; fruits include the cytochrome P subfamily A (CYPA) inhibitors Seville oranges, grapefruit, pummelos, or exotic citrus fruits
Patients who have taken herbal medications and certain fruits within  days prior to study enrollment are not eligible; herbal medications include, but are not limited to, St Johns wort, Kava, ephedra (ma huang), gingko biloba, dehydroepiandrosterone (DHEA), yohimbe, saw palmetto, tangelos and ginseng; exclusionary fruits include the cytochrome P family , subfamily A (CYPA) inhibitors Seville oranges, grapefruit, pummelos, or exotic citrus fruits
Patients who have taken herbal medications and certain fruits within  days prior to starting study drug; herbal medications include, but are not limited to St. Johns wort, Kava, ephedra (ma huang), gingko biloba, dehydroepiandrosterone (DHEA), yohimbe, saw palmetto, and ginseng; fruits include the cytochrome P, family , subfamily A (CYPA) inhibitors Seville oranges, grapefruit, pomelos, or exotic citrus fruits
Patients who have taken herbal medications and certain fruits within  days prior to starting study drug; herbal medications include, but are not limited to St. Johns Wort, Kava, and ephedra (ma huang), dehydroepiandrosterone (DHEA), gingko biloba, yohimbe, saw palmetto, and ginseng; fruits include the cytochrome P, family , subfamily A (CYPA) inhibitors Seville oranges, grapefruit, pummelos, or exotic citrus fruits
Patients who have taken herbal medications and certain fruits within  days prior to starting study drug, see section ....
Taking herbal medications and certain fruits and juices within  days prior to starting study drug; herbal medications include, but are not limited to St. Johns wort, Kava, ephedra (ma huang), gingko biloba, dehydroepiandrosterone (DHEA), yohimbe, saw palmetto, and ginseng; fruits and juice include the cytochrome P A (CYPA) inhibitors: Seville oranges, grapefruit, and pomelos
Patients who have taken herbal medications and certain fruits within  days prior to starting study drug; herbal medications include, but are not limited to St. Johns wort, Kava, ephedra (ma huang), gingko biloba, dehydroepiandrosterone (DHEA), yohimbe, saw palmetto, and ginseng; fruits include the cytochrome P, family , subfamily A (CYPA) inhibitors Seville oranges, grapefruit, pummelos, or exotic citrus fruits
Herbal preparations are not allowed throughout the study; these herbal medications include, but are not limited to: St. Johns wort, kava, ephedra (ma huang), gingko biloba, dehydroepiandrosterone (DHEA), yohimbe, saw palmetto, and ginseng; not willing to avoid grapefruit, grapefruit juices, grapefruit hybrids, Seville oranges, pummelos, and exotic citrus fruits from  days prior to the dose of study medication and during the entire study due to potential CYPA interaction with the study medication; orange juice is allowed