Creatinine =< . X ULN or calculated creatinine clearance (CrCl) > mL/min using the Cockcroft-Gault formula less than eight days prior to start of treatment within days of starting cycle day treatment Calculated creatinine clearance (CrCl) of ? mL/min by the Cockcroft-Gault formula. Serum creatinine =< . mg/dL OR measured creatinine clearance (CrCl) >= mL/min as calculated by the Cockcroft-Gault method OR -hour measured urine CrCl >= mL/min ARM - A: Calculated GFR > cc/min; creatinine clearance (CrCl) by Cockcroft Gault will be used to estimate GFR PHASE I: Calculated creatinine clearance (CrCl) >= mL/min calculated by Cockcroft-Gault formula PHASE IB: Calculated creatinine clearance (CrCl) >= mL/min calculated by Cockcroft-Gault formula CrCl of >= (as calculated by Cockcroft-Gault formula) Creatinine clearance (CrCL) >= mL/min/. m^ calculated by Cockcroft-Gault Creatinine =< X ULN or calculated creatinine clearance (CrCl) > mL/min using Cockcroft- Gault formula Body surface area (BSA)-normalized creatinine clearance >= mL/min/. m^ (using Cockcroft-Gault creatinine clearance [CrCl]) Creatinine clearance (CrCl) > mL/min, calculated using the Cockcroft-Gault formula Creatinine clearance (CrCL) > mL/min as measured via Cockcroft-Gault Serum creatinine < . x ULN or creatinine clearance (CrCl) > mL/min (measured or calculated using the Cockcroft-Gault formula) Creatinine clearance of >= mL/min; creatinine clearance (CrCl) should be calculated suing the Cockcroft-Gault formula Calculated creatinine clearance (CrCl) >= mL/min (if using the Cockcroft-Gault formula) Serum creatinine =< . x ULN or creatinine clearance (CrCl) >= mL/min should be obtained within days prior to enrollment\r\n* Use the Cockcroft-Gault formula \r\n* Alternatively to Cockcroft-Gault formula of CrCl, hour (hr) urine CrCl can be used Completed within days of surgery: Calculated creatinine clearance ? mL/min; the creatinine clearance CrCl is determined by the Cockcroft-Gault formula Calculated creatinine clearance (CrCl) or -hour urine CrCl > mL/min (Cockcroft-Gault formula will be used to calculate CrCl) (within days prior to registration) Calculated creatinine clearance (CrCl) or -hour urine CrCl > mL/min Cockcroft-Gault formula (using actual body weight) will be used to calculate CrCl, except for patients (pts) with osteosarcoma who will be allowed to participate with an estimated creatinine clearance (CrCl) of > mL/min, as calculated by the Cockcroft-Gault equation Creatinine clearance (CrCl) < ml/min by Cockcroft-Gault formula Creatinine clearance (CrCl) >= mL/min calculated by the Cockcroft-Gault method Calculated or measured creatinine clearance (CrCL) >= mL/min using modified Cockcroft and Gault formula A pretreatment creatinine clearance (CrCl) of >= mL/minute (min), calculated by Cockcroft Gault The estimated creatinine clearance (CrCl) must be equal or greater than mL/min/. m^ as calculated by the Cockcroft-Gault Formula Serum creatinine =< . x ULN, or measured creatinine clearance (CrCl) >= mL/min as calculated by the Cockcroft-Gault method or -hour measured urine CrCl >= mL/min Calculated creatinine clearance (CrCl) >= mL/min (Cockcroft-Gault method) Calculated creatinine clearance (CrCl) > cc/min/. m^, using the Cockcroft-Gault equation; note: a measured CrCl from a hour urine collection may also be used Creatinine clearance (calculated creatinine clearance is permitted) < mL/min based on Traditional Cockcroft-Gault formula\r\n* For patients < years: creatinine clearance (CrCl) will be estimated by the Schwartz formula; a measured CrCl or a glomerular filtration rate (GFR) may be substituted to determine the subjects CrCl Creatinine clearance (CrCl) >= mL/min as calculated by the Cockcroft-Gault method Renal function assessed by calculated creatinine clearance (CrCl) must be >= ml/min by Cockcroft-Gault formula Serum creatinine ?. x the ULN and a calculated creatinine clearance (CrCl) ? mL/min by the Cockcroft-Gault method. Creatinine clearance (CrCl) < mL/min (Cockcroft-Gault formula) at screening Body surface area (BSA)-normalized creatinine clearance >= mL/min/. m^ (using Cockcroft-Gault creatinine clearance [CrCl]) Creatinine clearance >= ml/min; creatinine clearance (CrCl) will be calculated by Cockcroft-Gault method Serum creatinine < . mg/dL or calculated creatinine clearance (CrCl) > mL/min (Cockcroft-Gault) Calculated creatinine clearance (CrCl) > mL/min using Cockcroft-Gault formula Patients must be ineligible for treatment with cisplatin, based on one of:\r\n* Calculated creatinine clearance (CrCl) >= and < mL/min (Cockcroft-Gault)\r\n* CTCAE grade (Gr) >= hearing loss\r\n* CTCAE Gr >= neuropathy Serum creatinine =< . g/dL or calculated creatinine clearance (CrCl) >= mL/min (Cockcroft-Gault method) Calculated or measured creatinine clearance (CrCl) rate of ? mL/min calculated using the formula of Cockcroft and Gault [( ? age) mass (kg) / ( serum creatinine mg/dL)]. Multiply result by . if female. Creatinine clearance (CrCl) >= mL/min by Cockcroft-Gault calculation Creatinine clearance (CrCl) >= mL/min per Cockcroft-Gault Creatinine clearance (CrCL) >= mL/min as measured via Cockcroft-Gault Patients must have calculated creatinine clearance >= ml/min by Cockcroft-Gault formula or hour urine demonstrating creatinine clearance (CrCl) >= ml/min Calculated creatinine clearance (CrCl) >= mL/min (Cockcroft-Gault formula), patients with a CrCl >= mL/min can be considered for the trial if patients are not in active renal failure and after discussion with the principal investigator (PI) Creatinine clearance >= ml/min; creatinine clearance (CrCl) can be measured or estimated using Cockcroft-Gault method Adequate renal function as assessed by calculated creatinine using Cockcroft-Gault estimation of creatinine clearance (CrCl); subjects must have calculated CrCl >= ml/min by Cockcroft-Gault formula Calculated creatinine clearance (CrCl) >= mL/min (using Cockcroft & Gault method) Renal: Serum creatinine ? . x ULN OR calculated creatinine clearance (CrCl) > ml/min as calculated by the Cockcroft-Gault method Calculated (method of Cockcroft-Gault) creatinine clearance (CrCl) >= mL/min (creatinine clearance may also be obtained by the -hour collection method at the investigators discretion) Creatinine clearance (CrCl) >= mL/min (modified Cockcroft-Gault) Serum creatinine ?. x ULN and a calculate creatinine clearance (CrCl) ? mL/min by the Cockcroft-Gault method Renal: Serum creatinine ? . x ULN or creatinine clearance (CrCl) ? ml/min as calculated by the cockcroft-gault method Serum creatinine ? . ULN OR calculated creatinine clearance (CrCl) or -hour urine CrCl ? mL/minute ? Cockcroft-Gault formula will be used to calculate CrCl; -hour urine CrCl will be derived using the measured creatinine clearance formula Serum Creatinine Clearance(CrCl) ? mL/min, either measured or calculated using a standard formula (e.g. Cockcroft and Gault) Calculated or measured creatinine clearance (CrCl) of ? mL/min within days prior to randomization. Calculation should be based on standard formula such as the Cockcroft and Gault: [( - Age) x Mass (kg) / ( x Creatinine mg/dL)]; multiply result by . if female. The estimated creatinine clearance (CrCl) must be equal or greater than mL/min/. m^ as calculated by the Cockcroft-Gault formula