Histologic diagnosis is mandatory for all patients prior to study entry; study eligibility will be based on institutional pathology; however, performance (and ultimate submission for Central Pathology review) of immunohistochemically (IHC) stained slides for INI (to rule out CNS AT/RT), GFAP, EMA, neuronal markers (synaptophysin) for all tumors, as well as a reticulin stain for medulloblastomas displaying any degree of desmoplasia on conventional microscopy, is required; in addition, requested, but not required, are IHC slides for P and MIB-/Ki- for all tumors
Histology slides reviewed and agreement between two clinical pathologists (not required to be at same institution) that pathology fulfills COMET eligibility criteria. In cases of disagreement between the two pathology reviews about whether or not a case fulfills the eligibility criteria, a third pathology review will be required.
Submission of tumor tissue is required for all patients; investigators should check with their site pathology department regarding release of biospecimens before approaching patients about participation in the trial
United States (US) and Canadian sites:\r\n* This review is mandatory prior to registration to confirm eligibility; patients must be willing to submit tissue samples for mandatory central pathology review submission; it should be initiated as soon after surgery as possible
Patients must have paraffin tissue from the diagnostic or relapse biopsy available to be submitted for central pathology review and integral molecular subtyping; this review is mandatory prior to registration to confirm eligibility and should be initiated as soon as possible; determination of cell-of-origin subtype will be performed using the lymphoma subtyping test (LST) assay
Tumor tissue must be available for submission for central pathology review\r\n* Timing requirements:\r\n** If MGMT has been assessed locally by LabCorps or MD Anderson Cancer Center Molecular Diagnostics Lab (MDACC-MDL):\r\n*** Tissue for central pathology review and central MGMT assessment and the official LabCorps or MDACC-MDL MGMT result must be received by the NRG Oncology Biospecimen Bank on or before postoperative calendar day \r\n*** The sites local MGMT report from LabCorp or MDACC-MDL will then be used to stratify the patient; a post-stratification MGMT central review will be performed, but step  registration and protocol treatment can proceed without central review of MGMT\r\n*** Patients whose tissue for central pathology review and official LabCorps or MDACC-MDL MGMT result cannot be received by NRG Oncology Biospecimen Bank on or before  calendar days after surgery may NOT enroll on this trial\r\n** If MGMT has not been assessed locally by LabCorps or MDACC-MDL:\r\n*** Tissue for central pathology review and central MGMT assessment must be received by the NRG Oncology Biospecimen Bank on or before postoperative calendar day \r\n*** Central MGMT analysis will be performed at MDACC-MDL and used for patient stratification; results will be conveyed to NRG Oncology within  business days of receipt of the tissue\r\n*** Patients who have not had local MGMT assessment by LabCorps or MDACC-MDL and whose tissue for central pathology review cannot be received by NRG Oncology Biospecimen Bank on or before  calendar days after surgery may NOT enroll on this trial\r\n* Tissue Requirements:\r\n** Patients must have at least  block of tumor tissue; submission of  blocks is strongly encouraged to maximize the chances of eligibility; in total, at least  cubic centimeter of tissue composed primarily of tumor must be present\r\n** Submission of an accompanying hematoxylin and eosin H&E slide(s) is MANDATORY\r\n** Diagnosis must be made by surgical excision, either partial or complete; stereotactic biopsy and cavitronic ultrasonic surgical (CUSA) techniques are not allowed
Tumor tissue that is determined by central pathology review prior to step  registration to be of sufficient quantity for central analysis of MGMT status
Patients must have specimens available and institutions must be planning to submit for centralized pathology review and for integrated translational medicine objectives
Patients must have had all visible tumor resected completely within  days prior to registration; CIS disease is not expected to be completely excised; all patients must have tumor tissue from the histologic diagnosis of recurrence available for central pathology review submission; failure to submit these materials will make the patient ineligible for this study
The patient must have a newly diagnosed unifocal intracranial meningioma, gross totally resected, and histologically confirmed as WHO grade II based upon pathology findings at the enrolling institution; WHO grade will be assigned according to WHO  criteria
NOTE: Central pathology review must occur between steps  and  of registration; once appropriate pathology specimens are received, central pathology review will occur within  days, and must confirm WHO grade II meningioma before the patient can proceed to step  registration and randomization
Pre-registration: Patients must have local diagnosis of papillary craniopharyngioma and have tissue slides available for submission to central pathology review; central pathology review will include immunohistochemistry (IHC) testing for BRAF VE mutation (VE clone) and beta-catenin IHC (membranous, non-nuclear pattern) if needed to confirm diagnosis of papillary craniopharyngioma
Patients must be newly diagnosed with histologically-proven primary pediatric hepatic malignancies including hepatoblastoma or hepatocellular carcinoma, except as noted below; note that rapid central pathology review is required in some cases; please note: all patients with histology as assessed by the institutional pathologist consistent with pure small cell undifferentiated (SCU) HB will be required to have testing for INI/SMARCB by immunohistochemistry (IHC) according to the practices at the institution
The pathology from the primary surgery must be reviewed and finalized at either Dana-Farber Cancer Institute/Brigham & Women's Hospital or the pathology department at any participating institutions
Biopsy-proven, systemic DLBCL with a proliferation rate =< %, that has been confirmed by an acquired immune deficiency syndrome (AIDS) Malignancy Clinical Trial Consortium (AMC)-approved site pathologist using hematoxylin and eosin (H&E) and immunohistochemical stains; if a hard copy of the pathology report is unavailable at the time of enrollment into the screening segment, a verbal report by the pathologist confirming the diagnosis must be documented in the medical chart; a hardcopy of the pathology report must be available prior to randomization (enrollment into the Treatment Segment); Note: measurable disease is not an entry requirement
Histologically proven intra-cranial or spinal ependymoma or anaplastic ependymoma; there must be pathologic or imaging confirmation of tumor progression or regrowth; the patients histologic diagnosis must be confirmed on central pathology review prior to registration step \r\n* If a patient has already had central pathology review at MD Anderson Cancer Center (MDACC) (for example, from a previous enrollment to protocol CERN-), the central pathology does not need to be repeated; previous pathology confirmation can be utilized for this studys pathology eligibility testing
A diagnosis of locally-assessed, biopsy-proven EBV+ PTLD with a pathology sample available for central review
Archival tissue confirming the diagnosis must be reviewed by Brigham and Women's Hospital (BWH)/Dana-Farber Cancer Institute (DFCI)/Massachusetts General Hospital (MGH) pathology
Patients for whom the clinical pathology report includes only IHC as + (does not reflex to ISH) may enroll without written report of ISH determined HER copy number, provided the investigational site confirms that archival tissue is available.
Availability of a representative tumor specimen and the corresponding pathology report for retrospective central confirmation of the diagnosis of FL or DLBCL
Presence of luminal B pathology
Tumor tissue, from either initial diagnosis or subsequent surgery, on formalin fixed paraffin embedded (FFPE) slides (n = ) must be available and submitted to the Pathology Laboratory at Childrens Medical Center-Dallas for correlative biological studies (including phosphorylated S /, phosphorylated S /, phosphorylated EBP, phosphorylated PRAS (pT), phosphorylated PSK, and PTEN expression); Note: central review of these slides is required, but may be completed concurrently with patient registration; completion of central review is not required prior to starting therapy
Patients previously treated outside of the University of Wisconsin (UW) must have their pathology slides sent to the UW for review and confirmation\r\n* NOTE: a copy of the pathology report is sufficient for registration
Pathologic diagnosis must be based on pathology or pathology review by Department of Pathology at Massachusetts General Hospital (MGH) or another Dana-Farber/Harvard Cancer Center (DF/HCC) institution and must be finalized within two weeks of the radiation start date
Mutational status requires a pathology report, genomic sequencing, or immunohistochemical report of a mutation or activation of the RAS/RAF/MEK/ERK pathway
PHASE II: Mutational status requires a pathology report, genomic sequencing, or immunohistochemical report of a mutation or activation of the RAS/RAF/MEK/ERK pathway
Patients must have  representative hematoxylin and eosin (H&E) stained thyroid tissue slides OR tumor block available for submission to central pathology review; this review is mandatory prior to registration to confirm eligibility
In the case of recurrent radiographically gross disease, pathologic diagnosis may be from time of original biopsy and/or surgery; pathology should be reviewed and confirmed at the participating institution
Patients must have histologically or cytologically confirmed LCH, ECD or HS; confirmation of outside pathology at Brigham and Womens Hospital (BWH) will be performed but is not mandatory prior to study enrollment
For patients with invasive breast cancer sentinel node biopsy (SLNB) must be performed; if SLNB performed prior to BCS and precision breast IORT, pathology report must confirm no evidence of nodal disease; SLNC may also be performed concurrently with BCS; if this is the case the pathology will not be available prior to IORT
Tumor size (based on evaluation of images or pathology if patient in the post-pathology cohort) must be less than or equal to  cm
Any other pathology or condition which the principal investigator may deem to negatively impact treatment safety
Progressive, histologically or cytologically diagnosed low or intermediate grade, neuroendocrine tumors confirmed by the Laboratory of Pathology, National Cancer Institute (NCI) or a pathology laboratory at the enrolling institution; disease progression is defined according to Response Evaluation Criteria in Solid Tumors (RECIST) criteria for progression of disease or any new lesions seen on -Gallium DOTATATE within  months prior to enrollment (per principal investigator [PI] discretion and if -Gallium DOTATATE is performed at the enrolling institution)
Must have pathology proven breast cancer. Pathology must be invasive ductal or lobular
All pathologic diagnoses of subjects from all enrolling sites will be confirmed with tissue block review of previously obtained specimens by Scott VandenBerg, M.D., Ph.D; this will be done in order to assure uniformity in the above subtypes for these sometimes difficult to diagnose tumors; once consent is obtained, subjects tissue/slides and corresponding pathology report should be forwarded for central review at University of California at San Diego (UCSD)
Biopsy proven KSHV-associated MCD, confirmed in the Laboratory of Pathology, Center for Cancer Research (CCR)
Have a diagnosis of multiple myeloma (MM); the MM diagnosis must be confirmed by internal pathology review of a fresh biopsy specimen at the Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance (FHCRC/SCCA)
STRATUM A: Participants with recurrent, progressive, or refractory non-WNT non-SHH (NWNS) medulloblastoma or ependymoma as confirmed through central pathology review
STRATUM B: Participants with recurrent, progressive, or refractory CNS tumors as confirmed through central pathology review
STRATUM C: Participants with recurrent, progressive, or refractory SHH Medulloblastoma and presence of either a or b as confirmed by central pathology review of the tumor specimen: a) copy number loss of q b) PTCH mutation
Have a diagnosis of BCMA+ multiple myeloma (MM) (>= % BCMA+ by flow cytometry on CD co-expressing plasma cells obtained within  days of study enrollment); the MM diagnosis must be confirmed by internal pathology review of a fresh biopsy specimen at the Fred Hutchinson Cancer Research Center (FHCRC)/Seattle Cancer Care Alliance (SCCA)
Pathology review at Monroe Dunaway (MD) Anderson (Note: if patients prostate biopsy was not read at MD Anderson, it must be reviewed at the study site to confirm eligibility).
Confirmation of diagnosis by internal pathology review of initial or subsequent biopsy or other pathologic material at Fred Hutchinson Cancer Research Center (FHCRC)/Seattle Cancer Care Alliance (SCCA)/University of Washington (UW)/Harborview Medical Center (HMC)
Has cardiac pathology, defined as:
Evidence of brain pathology or increase intracranial pressure.
Histologically-proven (preferably confirmed by National Institute of Health [NIH] pathology review if initial pathology was done outside of NIH, but not mandatory), surgically inoperable, PHEO/PGL patients
Any other pathology or condition that the principal investigator deems to negatively impact treatment safety
CRITERIA FOR LEUKAPHERESIS AND PRE-THERAPY EVALUATION: History or presence of clinically relevant central nervous system (CNS) pathology that, in the opinion of the PI or designee, is a contraindication to lymphodepleting chemotherapy or huJCAR infusion
Histologically or cytologically confirmed TNBC based on the most recent analyzed biopsy or other pathology specimen. TNBC determination as per local institution as per standard guidelines.
Participants must have histologically or cytologically confirmed carcinoma; central pathology review is not required; however, pathology will be reviewed at the Sidney Kimmel Comprehensive Cancer Center (SKCCC) at Johns Hopkins
Patients with Gilberts disease and absent hepatic pathology by history and clinical assessment maybe treated on study with bilirubin > the ULN for the institution if other liver function studies are within the normal range
Confirmation of diagnosis by internal pathology review of initial or subsequent biopsy or other pathologic material at the Fred Hutchinson Cancer Research Center (FHCRC)/Seattle Cancer Care Alliance (SCCA)
Confirmation of MCC by internal pathology review of initial or subsequent biopsy or other pathologic material
Non-Ductal Pathology: Lobular or Colloid type presence
Histological confirmation of expressing CD antigen as determined by pathology at the respective institution and central pathology review at Mayo Clinic Rochester; Notes: for phase I, all types of B-cell lymphomas are allowed to participate; for phase II, only DLBCL patients are allowed to participate; for phase I only, patients with primary mediastinal large B-cell (PMLBCL) or transformed lymphoma are allowed to participate; additional notes regarding slide submission: central pathology review is mandatory, but is retrospective in nature; slides must be submitted =<  days after registration to allow for confirmation of DLBCL diagnosis and to have sufficient material for GCB/ABC assessment by a gene-expression profiling method; patients can be enrolled prior to submission of slides; for phase II, if central review of pathology shows that the patient does not have DLBCL or the amount of formalin-fixed paraffin-embedded (FFPE) material is not considered sufficient for cell-of-origin (COO) analysis, the patient may remain on the study but the patient should be replaced
Patients whose pathology has squamous cell features unless there is an unequivocal determination of non-squamous pathology
High-grade peritoneal carcinomatosis from appendiceal adenocarcinoma\r\n* Moderate or poorly-differentiated adenocarcinoma, signet ring cell carcinoma or high-grade carcinoma as designated by University of California San Diego (UCSD) pathologic testing\r\n* May be initially determined from pre-CRS/HIPEC tumor pathology (for screening purposes), but must be confirmed with UCSD pathology from resected tumors as part of CRS/HIPEC
Diagnosis of hematologic malignancy meeting at least one of the disease status criteria outlined below; diagnoses from outside laboratories must be confirmed by review in the NCI laboratory of pathology
Histologically confirmed high-grade cervical intraepithelial neoplasia (CIN, CIN, or CIN/); a copy of the pathology report is required at the time of enrollment; only patients that had their biopsy performed at the University of Alabama at Birmingham (UAB) Colposcopy clinic will be included
COH pathology review confirms that research participant's diagnostic material is consistent with a lymphoproliferative B-cell neoplasm
City of Hope (COH) pathology review confirms that research participants diagnostic material is consistent with history of ALL with history of recurrence/progression/minimal residual disease (MRD) following prior therapy; additionally, CD positivity must be documented in a pathology report; however, it is not a requirement that the CD testing be performed by a COH pathologist; patients in second complete remission (CR) or higher with history of CD+ ALL on previous bone marrow biopsy are also eligible for the study
COH pathology review confirms that research participants diagnostic material is consistent with ALL; additionally, CD positivity must be documented in a pathology report; however it is not a requirement that the CD testing be performed by a COH pathologist
Baseline laryngeal pathology that would warrant intervention that could affect voice or swallow function
Any other pathology or condition where the principle investigator may deem to negatively impact treatment safety
Histologically proven recurrent meningioma or aggressive meningioma; note: confirmation of ESO expression and pathology is not required in patients with definitive radiologic evidence of meningioma who are unresectable, and in whom radiation therapy without biopsy is the standard treatment
Suspicious residual microcalcifications on mammography of either breast, unless negative for malignancy on pathology.
Lymphovascular space invasion (LVSI) on pathology specimen.
Kaposi sarcoma pathologically confirmed by Department of Pathology, Clinical Center, National Institutes of Health
Pathology confirmation of HL with City of Hope (COH) pathology review
Participants must have histologically proven primary (or locally recurrent after prior surgery) soft tissue sarcoma of the retroperitoneum; patients in the phase II portion of the trial will be primary soft tissue sarcomas only; extraskeletal chondrosarcoma is allowed; pathology must be reviewed at treating institution or Dana-Farber (DF)/Harvard Cancer Center (HCC) affiliate prior to study entry (for locally recurrent participants, biopsy and pathology review may be from time of original diagnosis); NOTE: for patients with retroperitoneal neoplasms that have ambiguous histological and/or immunohistochemical findings, the diagnoses of carcinoma, melanoma, and lymphoma should be excluded by immunohistochemical studies with antibodies to broad spectrum cytokeratin (AE/AE), S-, cluster of differentiation (CD), or LCA (leucocyte common antigen), respectively; if these diagnoses are excluded by immunohistochemistry, then patients presenting with primary non-visceral retroperitoneal masses that are felt to be \consistent with sarcoma\ shall be considered eligible for this trial
Patients must have recurrent or refractory intracranial ependymoma (including myxopapillary, clear cell, papillary, tanycytic, and anaplastic ependymoma) or subependymoma; patients with primary diagnosis of intracranial ependymoma with spinal cord metastases or relapse are eligible; the diagnosis must be confirmed by the Collaborative of Ependymoma Research Network (CERN) enrolling site's pathologist on tissue from either the initial presentation or time of recurrence prior to registration; for central pathology review and trial biological studies, submission of a paraffin block with tumor measuring at least  cm x  cm in area is preferred, but  x  micro molar (m) unstained sections on slides may be provided by the referring laboratory instead; tissue must be submitted within  days after enrollment for central processing and analysis
Pathology reviewed and the diagnosis confirmed at Stanford University Medical Center
AR positive tumours defined as any nuclear AR staining by IHC (enrolment may be based on local pathology findings; subsequent review of AR expression by central pathology laboratory will be carried out)
History or presence of clinically relevant CNS pathology
Histologically proven diagnosis of salivary cancer by central pathology review
Participants must undergo central pathology review to histologically confirm the diagnosis of glioblastoma or variants ( unstained slide or  haematoxylin and eosin [H&E] slide must be submitted to and reviewed by a pathologist at the Dana Farber Cancer Institute [DFCI] Coordinating Center prior to enrollment of the participant for central pathology review); participants will not be eligible if the prior diagnosis was low-grade glioma and a subsequent histological diagnosis of glioblastoma or variants was made (e.g. secondary GBM)
Well-differentiated (G or G) based on local pathology report, non-functional neuroendocrine tumor of GI, pancreatic or thoracic (including lung and thymus) origin.
Poorly-differentiated GEP-NEC based on local pathology report
Patients must have pathologically confirmed, previously untreated, unresected squamous cell carcinoma of the larynx, hypopharynx, oropharynx, oral cavity, or carcinoma of unknown head/neck primary within  days prior to step  registration; submission of hematoxylin and eosin (H&E) stained slides and formalin-fixed and paraffin-embedded (FFPE) tissue block (or punch biopsy of FFPE block) to the biospecimen bank at University of California, San Francisco (UCSF) for central review for oropharyngeal and unknown primaries and for p analysis for all other non- oropharyngeal primaries is mandatory for all patients; investigators should check with their pathology department regarding release of biospecimens before approaching patients about participation in the trial; for oropharyngeal and unknown primaries, submission of H&E and p stained slides to the biospecimen bank at UCSF for central review is also required prior to step  registration\r\n* Note: fine needle aspirates (FNA) samples are not acceptable since they do not provide enough material for PD-L and p testing
For patients with oropharyngeal cancer only: p negative, confirmed by central pathology review
Submission of tumor tissue is required for all patients; investigators should check with their site pathology department regarding release of biospecimens before approaching patients about participation in the trial
p positive by immunohistochemistry (defined as greater than % strong nuclear or nuclear and cytoplasmic staining of tumor cells, confirmed by central pathology review)
Pathology review by the study institution is required
Patients must be newly diagnosed and have a confirmed histologic diagnosis of nodular desmoplastic (ND) medulloblastoma or medulloblastoma with extensive nodularity (MBEN) from rapid central pathology screening review; please note: patients with Gorlin syndrome are eligible
Patient must agree to submit tissue (i.e., the original haematoxylin/eosin [H/E]-stained slides and immunohistochemistry studies) for central pathology review post-registration
Significant ongoing immunologic rejection based on pathology and clinical diagnosis (from time of transplant until randomization)
Adequate sections or a paraffin block from the original diagnostic specimen must be submitted for review by the lymphoma pathology group
Patients must have documented low-grade serous carcinoma; confirmation must occur by prospective pathology review prior to study entry; the prospective pathology review can be done on tissue from the recurrent carcinoma or from original diagnostic specimen
If central pathology review indicates a diagnosis other than ATC, the participant may continue treatment with lenvatinib per standard of care, at the discretion of the treating investigator. Participants deemed to have another diagnosis (not ATC) will be taken off this study and replaced for the purpose of efficacy analyses.
AMKL PATIENTS: Patients must have a confirmed diagnosis (by blood or bone marrow) of relapsed/refractory acute megakaryoblastic leukemia (AMKL), as defined by World Health Organization (WHO) criteria\r\n* NOTE: if diagnosis was performed an outside facility, a copy of the report is sufficient for registration purposes; however, local pathology review at one of the main sites should still be obtained
MF PATIENTS: Patients must have a confirmed diagnosis (by blood or bone marrow) of myelofibrosis (MF), as defined by WHO criteria\r\n* NOTE: if diagnosis was performed an outside facility, a copy of the report is sufficient for registration purposes; however, local pathology review at one of the main sites should still be obtained
Pathology confirmed by treating institutions pathology department
Availability of a representative tumor specimen and the corresponding pathology report for retrospective central confirmation of the diagnosis of FL
Tumour tissue for central pathology review and correlative studies must be provided.
Sufficient tissue available for central pathology review and MGMT methylation status evaluation
Patients must have a histologically proven diagnosis of endometrioid endometrial adenocarcinoma by endometrial curettage or biopsy within  weeks prior to registration; central pathology review will be required as part of the study but not for registration purposes
Metastatic or unresectable cancer that expresses KIT as documented in the patient's pathology report.
Availability of a representative tumor specimen and the corresponding pathology report for retrospective central confirmation of the diagnosis of FL or DLBCL
For patients with stage I or II disease, specimens for rapid central review have been submitted and the rapid central review diagnosis and staging must be available to be provided on the AHEP eligibility case report form (CRF)
Patients with stage I or II disease who do not have specimens submitted for rapid central pathology review by day  after initial surgical resection
Availability of a representative tumor specimen and the corresponding pathology report for retrospective central confirmation of the diagnosis of FL or DLBCL
Pathology material: hematoxylin and eosin (H&E) stain and immunohistochemistry (IHC) slides or a representative formalin-fixed paraffin-embedded (FFPE) tissue block along with the pathology report from initial diagnosis, should be sent to be reviewed, and the diagnosis confirmed by Mayo Clinic department (retrospective diagnostic review: treatment may commence prior to the Mayo Clinic review)
Participants must have pathologically confirmed soft-tissue sarcoma, which is metastatic or unresectable, sarcoma with no curative multimodality options (pathology review required for patients with pathology not previously reviewed at Dana-Farber Cancer Institute [DFCI], Brigham and Women's Hospital [BWH] or Massachusetts General Hospital [MGH])
Central pathology review submission; Note: this review for MART- positivity is mandatory prior to randomization to confirm eligibility
If slides of the primary tumor are not available for review, a biopsy of the recurrent or persistent tumor is required to confirm at least % clear cell histomorphology; the percentage of involvement must be documented in the pathology report or in an addendum to the original report
Presence of documented neuroendocrine differentiation on the original pathology report
City of Hope (COH) pathology review confirms that research participant's diagnostic material is consistent with history of intermediate or high grade B-cell NHL (e.g., DLBCL, MCL, or transformed NHL)
Collection of archival tissue specimens  outside institution biopsies need to be reviewed by Brigham and Womens Hospital (BWH) pathology department for confirmation of MCC; available slides and blocks from outside institutions will be requested by the patient coordinator and sent to the BWH pathology department for review; if unavailable, new tumor biopsy will be required prior entering in the study
Adults with a confirmed pathologic diagnosis of pheochromocytoma/paraganglioma by the Laboratory of Pathology, National Cancer Institute (NCI) when such tissue is available to confirm or in the event that outside tissue is not available:\r\n* An outside pathology report confirms the diagnosis of pheochromocytoma (Pheo)/paraganglioma (PGL), AND\r\n* The patient has nuclear medicine imaging studies that would only be positive in an adult patient with a diagnosis of Pheo/PGL (fluorordopa [F-DOPA], Dotatate, fluorodopamine [F-Dopamine] or metaiodobenzylguanidine [MIBG])
Patients must have a histologically confirmed diagnosis of metastatic or locally advanced, unresectable:\r\n* Soft tissue sarcomas (non-liposarcoma)\r\n* Osteosarcoma\r\n* Liposarcoma-high grade, de-differentiated, or myxoid\r\n* Note: pathology is not required to be reviewed at the treating institution; a copy of the pathology report is sufficient for eligibility purposes
History of or current relevant CNS pathology
Diagnosis of malignancy must be confirmed by the department of pathology at the institution where the patient is being enrolled prior to patient enrollment
Patients must have a histologically or cytologically confirmed non-central nervous system (CNS) primary solid malignancy at the time of initial diagnosis; NOTE: brain lesions are not required to have pathologic confirmation; in addition, a copy of the pathology report for the primary tumor is sufficient for registration purposes
Patients with Gilberts disease and absent hepatic pathology by history and clinical assessment maybe treated on study with bilirubin > the ULN for the institution if other liver function studies are within the normal range
Original breast core biopsy specimen available for pathologic review and staining by Yale School of Medicine Department of Pathology
Histolo-cytologically proven PMLBL (phase II)\r\n* PMLBL without central nervous system (CNS) involvement\r\n* Slides will be reviewed by the national pathology panel, but review is not mandatory before registration
Tumor specimen must be available for a central pathology review and prognostic and predictive biomarker evaluation
Histologically confirmed CD+ disease by central laboratory assessment and pathology review
Histologically documented mantle cell lymphoma with co-expression of CD and CD and lack of CD expression by immunophenotyping and at least one of the following confirmatory tests: ) positive immunostaining for cyclin D; ) the presence of t(;) on cytogenetic analysis; OR ) molecular evidence of B-cell leukemia/lymphoma  (bcl-)/immunoglobulin heavy locus (IgH) rearrangement\r\n* Cases that are CD-negative and/or CD-positive will be eligible provided that the histopathology is consistent with mantle cell lymphoma AND positive for cyclin D, t(;), or bcl-/IgH rearrangement\r\n* A tissue block or unstained slides (   slides) will be submitted to the Roswell Park Cancer Institute (RPCI) Pathology Department for central pathology review\r\n* A diagnosis based on peripheral blood or bone marrow aspirate is allowed; if the diagnosis is based only on blood, in addition to the immunophenotype and molecular confirmation above, a peripheral blood smear must be available for central pathology review; if the diagnosis is based on a bone marrow, the bone marrow core biopsy or aspirate clot tissue block will be submitted to the RPCI Pathology Department: if the tissue block is not available please submit the diagnostic smears for review
Patients previously treated outside of Northwestern must have their pathology slides sent to Northwestern for review and confirmation\r\n* NOTE: a copy of the pathology report is sufficient for registration
Participants must have histologically or cytologically confirmed carcinoma; central pathology review is not required; however, pathology will be reviewed at Brigham and Women's Hospital (BWH)/Dana-Farber Cancer Institute (DFCI)
Diagnosis of malignancy must be confirmed by the department of pathology at the institution where the patient is enrolled prior to patient enrollment
Patients must have histologically confirmed alveolar soft part sarcoma; pathology should be confirmed at the Laboratory of Pathology, National Institutes of Health
Tumor material available for central p/q assessment, central O-methylguanine-deoxyribonucleic acid (DNA) methyltransferase promoter methylation status assessment, isocitrate dehydrogenase mutation analysis, and central pathology review
Histologically confirmed metastatic and/or advanced mesothelin-positive PDA as determined by central pathology lab review
Histology slides and pathology material must be available at the site for each patient before enrollment in order to be sent to the leading institution of the study for central pathology review and pharmacodynamic studies
TREATMENT: NCI Laboratory of Pathology confirmation of diagnosis of sarcomas, melanomas, germ cell tumors, or epithelial malignancies metastatic to the lungs, mediastinum, or pleura must have been obtained
Histologic sections for all patients must be submitted for pathology review; failure to submit pathology materials will render the patient non-evaluable for response but evaluable for toxicities
Availability of an archival or newly obtained tumor sample (collected at diagnosis or progression) with accompanying pathology report
Subjects must have HER-positive tumors and written clinical pathology report documentation of HER status available for Sponsor's Medical Monitor review.
Subjects for whom the clinical pathology report includes only IHC as + (does not reflex to ISH) may enroll without a written report of ISH determined HER copy number, provided the investigative site confirms that archival tissue is available.
Cytologic or histologic proof of pancreatic ductal carcinoma is required prior to study entry; this diagnosis must be confirmed by pathology review at a Dana-Farber (DF)/Harvard Cancer Center (HCC) institution
Histological confirmation of intermediate or high grade soft-tissue sarcoma. Tissue must be sent to a central pathology lab for review but will not preclude entry onto the study. Final assignment of tumor grade and histology will be based on the designation provided by the central pathology review.
The Phase II, single-arm NF Cohort (Arm G) will be required to submit tissue and pathology report for central pathology review.
Histologically proven ependymoma or anaplastic ependymoma; there must be pathologic or imaging confirmation of tumor progression or regrowth; the patients histologic diagnosis must be confirmed on central pathology review prior to registration step 
A diagnosis of locally-assessed, biopsy-proven EBV+ PTLD with a pathology sample available for central review
Histologically proven, unresectable, locally advanced or metastatic liposarcoma (dedifferentiated, myxoid round cell, or pleomorphic) or leiomyosarcoma. Participants must have a pathology report indicating the diagnosis of liposarcoma or leiomyosarcoma that has been reviewed by the sponsor before randomization may occur
Pathology specimens (example [e.g.], tumor blocks or unstained slides) for potential centralized pathology review and biomarker studies
Collection of the specimen: Pathology specimens (example (e.g.), tumor blocks or unstained slides) for potential centralized pathology review and biomarker studies is not applicable
Patients must have unequivocal evidence for tumor recurrence or progression by histology as determined by review of pathology by an attending neuro-pathologist at UCSF
Tumor tissue must be available for submission for central pathology review
Exhibits signs of respiratory tract pathology (including a sore throat preoperatively)
Airway pathology/facial abnormality
Referred to Section of Speech Pathology and Audiology for swallowing evaluation
A single, biopsy-proven SISCCA as defined by the LAST criteria (=<  mm depth of invasion, horizontal spread of =<  mm, and completely excised with at least  mm margin clear of cancer irrespective of the amount of HSIL) documented per investigator assessment in combination with the pathology report within  weeks before Segment B enrollment
Patients with nerve pathology or clinically identified neuropathy
Previous or existing pathology of the external or middle ear which would preclude auditory testing and/or intratympanic dexamethasone delivery
Previous or existing pathology of the central nervous system with potential to impact auditory pathways (i.e. major head trauma, meningitis, encephalitis, brain metastasis, vestibular schwannoma)
Salivary gland hypofunction regardless of underlying pathology
Previous diagnosis of Barretts esophagus, confirmed by pathology
Diagnosis of an abnormal Pap will be confirmed by pathology report
Women diagnosed with DCIS or ADH lesions detected by pathology
Patients with high-grade cervical intraepithelial lesions (CIN/) confirmed by colposcopy, biopsy, and review of the biopsy pathology slides by two pathologists
There is documented concordance* between the initial breast imaging finding and the core biopsy pathology report; the core needle biopsy must contain FEA or IPWA, according to the local pathologist; (it is possible that the central pathology review which is done after the patient is registered on this protocol will have a diagnosis discrepant from that made by the original institutions pathologist; in that case, the study team will communicate this to the original institutions site investigator within one week of the date of the central pathology review having been finalized); patients may have a personal history of prior or concurrent fibroadenoma and a prior history of proliferative breast lesions with or without atypia\r\n* Concordance is a determination by the radiologist (or his or her covering provider) performing an image-guided core needle biopsy that the pathology report from this procedure corresponds to the imaging appearance of a given lesion and that the said lesions most representative portion has been sampled
Discordance between the initial breast imaging finding and the core biopsy pathology report
Participants must have biopsy confirmed and clinical stage  or stage  breast carcinoma; if biopsy was done at an outside hospital, pathology will be reviewed at Brigham and Women's Hospital (BWH)/Dana-Farber Cancer Institute (DFCI)
Patients must have a history of histologically or cytologically confirmed prostate cancer; the outside pathology report is acceptable for study entry; every effort will be made to acquire the outside pathology slides to be confirmed by the Laboratory of Pathology, NCI
Location of cancer specified in the pathology report
Pathology reviewed by Moffitt pathologist
Pathology not reviewed by Moffitt pathologist
Exposure risk for KSHV infection (including being a first or second generation immigrant from an endemic area, or male-to-male sexual activity) or evidence of KSHV infection demonstrated by one of:\r\n* Molecular evidence of KSHV in whole blood, confirmed by testing at Focus Laboratories, CA (human herpes virus- [HHV-] quantitative polymerase chain reaction [PCR], Focus Unit Code )\r\n* Immunohistochemical evidence of KSHV in tissues (for example by staining for latency\r\nassociated nuclear antigen [LANA] or viral [v] IL-) confirmed in the Laboratory of Pathology, Center for Cancer Research (CCR), National Cancer Institute (NCI)\r\n* Presence of KS or primary effusion lymphoma (PEL) (KSHV-associated malignancies), confirmed in the Laboratory of Pathology, CCR, NCI
Biopsy proven KSHV-associated multicentric Castleman disease (MCD), confirmed in the Laboratory of Pathology, CCR, NCI
Women must have newly diagnosed histologically confirmed ER positive (+) DCIS scheduled to undergo surgical therapy; the pathology report (signed pathology report from attending pathologist) from each individual institution will be used to determine eligibility\r\n* Note: After the patient has completed the study and the slides have been sent to Northwestern University (NU), our pathologists will review the slides to confirm the diagnosis\r\n* Note: DCIS suspicious for micro invasion is eligible on core biopsy