Subjects must have histologically confirmed metastatic melanoma with measurable (by RECIST v.), stage III (lymph node or in transit lesions) or stage IVA, IVB, or IVC disease that is accessible for injection.
Diagnosis of selected stage III or IVa/b head and neck squamous cell carcinoma (HNSCC); all patients must have T-T primary tumors (patients with T tumors will be excluded); although most of these patients will have regional nodal disease, patients with no nodal disease will also be eligible
ARM  - A: Diagnosis of selected stage III or IVa/b HNSCC; all patients must have T-T primary tumors (patients with T tumors will be excluded); although most of these patients will have regional nodal disease, patients with no nodal disease will also be eligible
High-intermediate risk disease, defined as:\r\n* T-T N M or T N M or any stage III (T or N) p+ squamous cell carcinoma of the oropharynx (The American Joint Committee on Cancer [AJCC] th edition staging system)\r\n* T- N- M or T- N- M (stage III-IVB) p+ squamous cell carcinoma of the hypopharynx or larynx\r\n* T- N- M or T- N- M (stage III-IVB) p+ squamous cell carcinoma of the nasopharynx\r\n* Inoperable T N- M (stage IVA-IVB) p+ squamous cell carcinoma of the oral cavity
Patients with stage I-IVA are eligible
Suspected or histologically/cytologically confirmed oropharyngeal squamous cell carcinoma (OPSCC), stage II, III, or IVA (according to the American Joint Committee on Cancer [AJCC] th edition), or patients with loco-regional recurrence from an OPSCC primary, if time of recurrence is at least  months after completion of initial curative intent treatment (surgery or radiotherapy +/- chemotherapy or cetuximab). Patients with a suspected lesion may be enrolled and a baseline biopsy will be obtained as part of the study. If squamous cell histology is not confirmed, patients will be discontinued from the study
Any patient eligible for internal implantation without MR guidance will be considered eligible for this protocol; standard criteria for internal implantation include:\r\n* Carcinoma of the cervix: stage I-IVA or vaginal recurrence\r\n* Carcinoma of the uterus: stage IIIB (vaginal involvement), inoperable, or vaginal recurrence\r\n* Carcinoma of the vagina: stage I-IVA or vaginal recurrence\r\n* Carcinoma of the vulva: stage I-IVA or recurrence\r\n* Carcinoma of the urethra based on treating physicians discretion
Measurable, unresectable stage III (in transit lesions) or stage IVA, IVB or IVC disease
Have TNM clinical stage III, IVA, or IVB disease
Surgical Stage IVA includes patients with bladder or bowel mucosal involvement, but no spread outside the pelvis.
Histologically confirmed diagnosis of squamous cell carcinoma of the larynx, stages III, IVa, or IVb, p-negative on immunohistochemistry
Biopsy-proven, unresected stage IB-IVA invasive carcinoma of the cervix
Pathological stage I-IVa HNSCC
Pathologic diagnosis of stage IB-IVA squamous, adenocarcinoma, or adenosquamous carcinoma of the uterine cervix or stage II-IVA squamous or adenocarcinoma of the vulva that is not amenable to curative surgical resection alone
Stage III or stage IVA or IVB disease prior to induction chemotherapy with no proven hematogenous metastatic disease
Patients with metastatic disease (only stage III or IVA-B patients permitted)
Patients who are treatment nave, high risk, stage IVa/IVb (all other sites) and histologically proven squamous cell carcinoma of the head and neck (SCCHN) with no definitive evidence of metastatic disease, excluding patients with oropharynx human papillomavirus (HPV)-positive tumors; in summary, those patients eligible are newly diagnosed and treatment naive: \r\n* Stage IVa-b squamous cell carcinoma other than oropharyngeal cancer (OPC), or\r\n* Oropharyngeal cancer (OPC) HPV-negative, stage IVa-b
Patients who are treatment nave, high risk, stage IVa/IVb (all other sites) histologically proven SCCHN with no definitive evidence of metastatic disease; in summary, those patients eligible are:\r\n* Stage IVa-b SCCHN other than OPC, or\r\n* OPC, HPV-negative, IVa-b, or\r\n* OPC, HPV positive, with greater than  pack-year smoking history and Nb-N disease
Clinical Masaoka stage II (>  cm), III, or IVA, including suspected invasion of mediastinum, pericardium, lung, great vessels or chest wall, and/or pleural metastases
Pathologically confirmed (histology or cytology) clinical Stage II, III, or IVA squamous cell cancer of the oral cavity (excluding lip). Subjects must be staged using AJCC Cancer Staging Manual Edition . (appendices  and ).
Patients must have histologically confirmed metastatic melanoma with measurable, stage III (lymph node or in transit lesions) or stage IVA, IVB, or IVC disease.
Suspected or histologically/cytologically confirmed head and neck squamous cell carcinoma (HNSCC) of the oral cavity, stage III, IVA or IVB (according to the American Joint Committee on Cancer [AJCC] th edition); patients with a suspected lesion may be enrolled and a baseline biopsy will be obtained as part of the study; if squamous cell histology is not confirmed, patients will be discontinued from the study
Advanced stage NSCLC (stage IVa [malignant pleural effusion (is now staged as stage IVa by the most recent staging system), or stage IV, or recurrent disease])
Any patient eligible for internal implantation without MR guidance will be considered eligible for this protocol; standard criteria for internal implantation include:\r\n* Carcinoma of the cervix: stage I-IVA or vaginal recurrence\r\n* Carcinoma of the uterus: stage IIIB (vaginal involvement), inoperable, or vaginal recurrence\r\n* Carcinoma of the vagina: stage I-IVA or vaginal recurrence\r\n* Carcinoma of the vulva: stage I-IVA or recurrence\r\n* Carcinoma of the urethra/bladder
Women with clinical stage IB-IVA cervical squamous cell carcinoma, adenosquamous, or adenocarcinoma
Patient must be American Joint Committee on Cancer (AJCC) stage III (TN, T-N) or stage IVa (T-N-M, TN- M) or stage IVb (unresectable disease) and be either unresectable or borderline resectable
Histological or cytological diagnosis of squamous cell carcinoma (SCC) of head and neck with American Joint Committee on Cancer (AJCC) Stage III, IVA or IVB and not amenable to surgical resection or locoregional radiation therapy with curative intent.
Disease may be stage I, II, III or IVA (as long as it is deemed resectable by the surgical team)
Histologically or cytologically confirmed squamous cell carcinoma, previously untreated stage II, III, or IVA HNC; patients with clinical stage III or IVA disease must undergo computed tomography (CT) or magnetic resonance imaging (MRI) to rule out the presence of distant metastases
Dose escalation: Patients with metastatic melanoma with measurable, stage III (in transit lesions) or stage IVA, IVB or IVC disease (at least  measurable lesions/tumors; patients will be required to have one more lesion resent than the number the current dose level requires since one lesion will be left untreated
Expansion cohorts: Patients with metastatic melanoma with measurable, stage III (in transit lesions) or stage IVA, IVB or IVC disease at least two measurable lesions/tumors
Patients must have completed curative-intent therapy (including surgery, radiation, and/or chemotherapy) for a first tobacco-related oral premalignant lesion (OPL) or HNSCC of any stage (eligible lesions include high grade dysplasia; carcinoma in situ; or stage I-IVa HNSCC); NOTE: the presence of a measurable OPL at baseline is not required