Must not have received investigational therapy within days of entry onto this study Patients should have been off other investigational therapy for one month prior to receiving treatment on this study TREATMENT: Patients should have been off other investigational therapy for one month prior to entry in this study Prior investigational therapy (medications or devices) within weeks of treatment. Patients should have been off other investigational therapy for one month prior to entry in this study Patients should have been off other investigational therapy for one month prior to receiving treatment on this study INCLUSION - INFUSION: Patients should have been off other investigational therapy for weeks prior to entry in this study Other investigational therapy: at least two weeks since any other investigational therapy Prior systemic chemotherapy or therapy with one of the investigational agents within month prior to enrollment Patients who had therapy with one of the investigational agents more than month prior to enrollment in whom tumor genotyping show assignment to the same investigational agent Patients should have been off other investigational therapy for one month prior to entry in this study off other investigational therapy for one month prior to entry in this study. No other investigational antitumor therapy for one month prior to entry in this study Treatment with investigational therapy within days prior to randomisation No prior investigational therapy within weeks prior to study enrollment Treatment with radiation therapy, surgery, chemotherapy, or investigational therapy within four weeks prior to study entry Treatment with radiation therapy, surgery, or investigational therapy within one month prior to registration Participant may have received prior investigational therapy (including immune therapy) Other investigational therapy (within days of Study Day ). Investigational therapy within weeks of screening TREATMENT: Patients should have been off other investigational therapy for one month prior to entry in this study Recent Investigational therapy Patients who are receiving concurrent investigational therapy or who have received investigational therapy within days of the first scheduled day of protocol treatment Patients should have been off other investigational therapy for weeks prior to entry in this study Treated with any investigational therapy within weeks of the first dose of study treatment. Prior investigational therapy within the past days. Investigational therapy within weeks. Investigational therapy within weeks of Screening. Investigational therapy within weeks prior to CMB dosing Investigational therapy within weeks prior to CMB dosing Treatment with radiation therapy, surgery, chemotherapy, or investigational therapy within days prior to study entry. Investigational therapy within weeks prior to LV dosing. Any investigational therapy within days prior to the first dose of IP. Any investigational therapy within days prior to the first dose of IP. Concurrent investigational therapy or investigational therapy within weeks of start of afatinib therapy Investigational therapy within weeks prior to G dosing Investigational therapy within weeks of Screening. Treatment with investigational therapy within weeks of study treatment AT THE TIME OF INFUSION: Off investigational therapy for weeks prior to study entry Other investigational therapy (not included above) within weeks of randomization Ongoing treatment with any other investigational therapy Subjects who received any investigational medication, prior local therapy for pancreas cancer , or any significant change in treatment within month prior to screening Concurrent investigational treatment, chemotherapy, or targeted therapy; prior chemotherapy, hormonal therapy, targeted therapy, and investigational agents are allowed but all toxicities grade >= must have resolved by the time of study commencement (except alopecia) Subject may have received prior investigational therapy (including immune therapy) Patients should have been off other investigational antiviral or antitumor therapy for one month prior to entry in this study Ongoing investigational treatment Prior to study treatment administration, at least days must have elapsed since the subject's prior investigational or non-investigational systemic therapy, or any major surgery, and at least days since prior radiotherapy. Any investigational therapy in the past days Investigational therapy less than one month prior to study entry Ongoing treatment with any other investigational therapy An investigational therapy. Investigational therapy or any other therapy =< days before first study treatment Has received investigational therapy within weeks prior to randomization Patient is receiving or plans to receive other investigational therapy during study. Patients should have been off other investigational therapy for one month prior to entry in this study