History of chronic inflammatory bowel disease or Crohn's disease requiring medical intervention (immunomodulatory or immunosuppressive medications or surgery) ? months prior to randomization No history of serious digestive and/or absorptive problems, including inflammatory bowel disease and chronic diarrhea that preclude adherence to the study diet Known history of colitis, inflammatory bowel disease, pneumonitis, pulmonary fibrosis. Have inflammatory bowel disease for which the participant has used immunosuppressive agents within the last years. Active diarrhea or inflammatory bowel disease Patients with history of and/or active inflammatory bowel disease. Participants with inflammatory bowel disease Active inflammatory or other gastrointestinal disease, Known history of colitis, inflammatory bowel disease, pneumonitis, or pulmonary fibrosis. Inflammatory or chronic functional bowel disorder such as Crohn's Disease, inflammatory bowel disease, chronic diarrhea, or constipation Current acute or chronic colitis, inflammatory bowel disease, pneumonitis or pulmonary fibrosis. History of inflammatory bowel disease Inflammatory eye disease requiring steroid treatment History of inflammatory bowel disease History of inflammatory bowel disease, autoimmune disease, or other connective tissue diseases Patients with history or current diagnosis of inflammatory bowel disease are not eligible Any condition or history of active rectal inflammatory bowel disease or other factors which might increase the risk of fistula formation; Active inflammatory bowel disease, other bowel disease causing chronic diarrhea (defined as > loose stools per day), or bowel obstruction Inflammatory bowel disease Patients with inflammatory bowel disease Current severe acute or chronic colitis, inflammatory bowel disease, pneumonitis, pulmonary fibrosis Patients with inflammatory bowel disease Active or prior documented inflammatory bowel disease History of inflammatory bowel disease; Severe (requiring active treatment) acute or chronic medical conditions including: colitis, inflammatory bowel disease, pneumonitis, or pulmonary fibrosis All other significant diseases (for example, colitis, pneumonitis, pulmonary fibrosis, inflammatory bowel disease, uncontrolled asthma) malabsorption syndromes such as celiac disease, cystic fibrosis, inflammatory bowel disease, systemic sclerosis, and carcinoid syndrome History of hemorrhagic diarrhea, inflammatory bowel disease or active uncontrolled peptic ulcer disease; (concomitant therapy with ranitidine or its equivalent and/or omeprazole or its equivalent is acceptable); history of ileus or other significant gastrointestinal disorder known to predispose to ileus or chronic bowel hypomotility Inflammatory bowel disease Clinical contraindication to stereotactic body radiotherapy as determined by the investigator (e.g., active systemic sclerosis, active inflammatory bowel disease if bowel is within radiation field) Poorly controlled inflammatory bowel disease History of inflammatory bowel disease Uncontrolled inflammatory bowel disease Patients with active inflammatory bowel disease Patients with inflammatory bowel disease History of inflammatory bowel disease Has active or prior inflammatory bowel disease or primary immunodeficiency There are no exclusions due to co-morbid disease or illnesses except for patients who carry a diagnosis of Inflammatory Bowel Disease that has been active within the last year History of inflammatory bowel disease History of or ongoing inflammatory bowel disease Known history of autoimmune colitis, inflammatory bowel disease, pneumonitis, pulmonary fibrosis; Known history of immune-mediated colitis, inflammatory bowel disease, pneumonitis, pulmonary fibrosis. Any medical condition that would be a contra-indication to radiation therapy, such as inflammatory bowel disease Patients must not have a history of inflammatory bowel disease or diverticulitis (history of diverticulosis is allowed) No standard contraindications to radiation therapy including prior significant radiation therapy, inflammatory bowel disease, irritable bowel syndrome or collagen vascular disease Patients with significantly diseased or obstructed gastrointestinal tract that could interfere with absorption of oral medication, including inflammatory or chronic functional bowel disorder, such as Crohn disease, inflammatory bowel disease, chronic diarrhea, or constipation History of inflammatory bowel disease requiring ongoing therapy DONOR: History of or symptoms consistent with inflammatory bowel disease or a serious autoimmune disorder Inflammatory bowel disease Active inflammatory bowel disease Patients with history of inflammatory bowel disease, or who require steroid or cytotoxic therapy for collagen vascular disease Patients must not have a history of inflammatory bowel disease or diverticulitis (history of diverticulosis is allowed) Patients with active inflammatory bowel disease The participant has a history of inflammatory bowel disease or Crohn's disease requiring medical intervention within months. Patient must not have a history of inflammatory bowel disease requiring pharmacological and/or surgical intervention within the months prior to randomization Patient must have no active inflammatory bowel disease Active inflammatory bowel disease or chronic diarrhea, short bowel syndrome, or any upper gastrointestinal surgery including gastric resection. Ongoing inflammatory bowel disease History of inflammatory bowel disease Active inflammatory bowel disease or chronic diarrhea, short bowel syndrome, or upper gastrointestinal surgery including gastric resection History of inflammatory bowel disease or active bowel inflammation History of inflammatory bowel disease, prior bowel surgeries (or colostomy) for any reason, or prior partial/radical cystectomy for any reason have active gastrointestinal (GI) disease characterized by inflammatory bowel disease, malabsorption syndrome, or frequent Grade or more diarrhea Inflammatory bowel disease Have a history of inflammatory bowel disease or Crohn's disease requiring medical intervention (immunomodulatory or immunosuppressive medications or surgery) ? months prior to randomization. Clinical contraindication to stereotactic body radiotherapy (e.g. active systemic sclerosis, active inflammatory bowel disease if bowel is within target field, etc) History of chronic inflammatory bowel disease or Crohn's disease requiring medical intervention (immunomodulatory or immunosuppressive medications or surgery) =< months prior to randomization Active inflammatory bowel disease Inflammatory bowel disease Inflammatory bowel disease or connective tissue disease requiring medical management Known history of immune mediated colitis, inflammatory bowel disease, pneumonitis, pulmonary fibrosis. History of autoimmune disease, including inflammatory bowel disease History of inflammatory bowel disease Prior history of scleroderma or inflammatory bowel disease Clinical contraindication to stereotactic body radiotherapy (e.g. active systemic sclerosis, active inflammatory bowel disease if bowel is within target field, etc) For abdominal or pelvic irradiation: active inflammatory bowel disease Any chronic inflammatory bowel disease and/or chronic bowl obstruction Known history of colitis, inflammatory bowel disease, pneumonitis, or pulmonary fibrosis history of inflammatory bowel disease of the rectum; Ongoing inflammatory bowel disease History of autoimmune disease or known inflammatory bowel disease. History of inflammatory bowel disease Patients with a history of inflammatory bowel disease Ongoing inflammatory bowel disease Patients with history of inflammatory bowel disease or major bowel surgery Ongoing gastrointestinal medical condition such as Crohn's disease, Inflammatory bowel disease, chronic diarrhea, or constipation Ongoing inflammatory bowel disease Known clinically significant gastrointestinal disease including, but not limited to, inflammatory bowel disease Active or prior documented autoimmune, or inflammatory bowel disease, or inflammatory bowel disease. or systemic treatment for psoriasis within the past years.; Known clinically significant gastrointestinal disease including, but not limited to, inflammatory bowel disease Ongoing inflammatory bowel disease Active inflammatory bowel disease Subjects with known clinically significant gastrointestinal disease including, but not limited to, inflammatory bowel disease Known clinically significant gastrointestinal disease including, but not limited to, inflammatory bowel disease Patients with active inflammatory bowel disease Known clinically significant gastrointestinal disease including, but not limited to, inflammatory bowel disease Prior history of inflammatory bowel disease. Gastrointestinal (GI) disease with increased risk of diarrhea (e.g. inflammatory bowel disease) History of or active inflammatory bowel disease or active bowel inflammation History of inflammatory bowel disease Gastro-intestinal disease with increased risk of diarrhea (e.g. inflammatory bowel disease) Gastrointestinal (GI) disease with increased risk of diarrhea [e.g. inflammatory bowel disease (IBD)] Active inflammatory bowel disease or other bowel disease causing chronic diarrhea. Patients with inflammatory or chronic functional bowel disorder, such as Crohn disease, inflammatory bowel disease, or gastrointestinal graft versus host disease that in the opinion of the investigator may interfere with absorption of ponatinib or increase the risk of serious complications Have a history (within years) of inflammatory bowel disease, History of inflammatory bowel disease History of or active inflammatory disease or active bowel inflammation Patients with gastrointestinal disease or disorder that could interfere with absorption of CUDC-, such as bowel obstruction or inflammatory bowel disease History of clinically significant Crohns disease or inflammatory bowel disease (IBD) Any history of inflammatory bowel disease Prior history of inflammatory bowel disease or other chronic diarrheal illness Clinically significant systemic infection or uncontrolled chronic inflammatory disease (eg, rheumatoid arthritis, inflammatory bowel disease) as determined by the investigator during screening. Inflammatory bowel disease (IBD)/Crohn's Patients with a history of gastric bypass surgery or inflammatory bowel disease Prior colorectal surgery or history of inflammatory bowel disease Any history of inflammatory bowel disease Patients with inflammatory bowel disease Diagnosis of inflammatory bowel disease, liver or kidney disease, bleeding diathesis Patient has a history of severe GI tract insult including but not limited to previous bowel perforation, grade neutropenic colitis or typhlitis, inflammatory bowel syndrome, short small bowel syndrome (Crohns disease, ulcerative colitis) or history of bowel resection Those with a family history, previous history of removing polyps, inflammatory bowel disease, or diagnosis of colorectal cancer No history of Inflammatory bowel disease Individuals with inflammatory bowel disease Inflammatory bowel disease Has severe colitis of any etiology or a history of inflammatory bowel disease (IBD) Diagnosis of inflammatory bowel disease Serious digestive and/or absorptive problems, including inflammatory bowel disease and chronic diarrhea that preclude adherence to the study diet. Personal history of inflammatory bowel disease History of CRC, bowel resection, polyposis syndrome, or inflammatory bowel disease Contraindications to radiotherapy (including active inflammatory bowel disease or prior pelvic radiation therapy [XRT]) Contraindications to radiotherapy (including active inflammatory bowel disease). Active inflammatory bowel disease within the last months Patients with active inflammatory bowel disease Active inflammatory bowel disease within the last months Any active cancer, history of gastrointestinal cancer, or chronic disease such as peptic ulcer, irritable bowel syndrome, inflammatory bowel disease, intestinal malabsorption syndrome or other gastrointestinal disorder Self-reported inflammatory bowel disease No history of inflammatory bowel disease History of inflammatory bowel disease Has a history of inflammatory bowel disease or history of scleroderma History of inflammatory bowel disease.