Patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Eastern Cooperative Oncology Group (ECOG) performance status =< (patients who are wheelchair bound because of paralysis secondary to a plexiform neurofibroma should be considered ambulatory when they are up in their wheelchair; similarly, patients with limited mobility secondary to need for mechanical support (such as an airway PN requiring tracheostomy or continuous positive airway pressure [CPAP] will also be considered ambulatory for the purpose of the study) Patients must have a Lansky performance status score of >= or a Karnofsky score of >= for patients >= years of age; Note: Patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Patient must have a Karnofsky performance status or Lansky* play status >= \r\n* For purpose of determining performance scores, wheelchair-bound patients will be considered ambulatory Karnofsky or Lansky performance score is ? % (corresponding to Eastern Cooperative Oncology Group [ECOG] score of ? ); the Lansky performance score should be used for participants < years and the Karnofsky performance score for participants ? years; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score STRATUM A: Participants must have a Lansky (=< years) or Karnofsky (> years) score of at least at the time of study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score STRATUM B: Participants must have a Lansky (=< years) or Karnofsky (> years) score of at least at the time of study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score STRATUM C: Participants must have a Lansky (=< years) or Karnofsky (> years) score of at least at the time of study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Subjects must have a Lansky performance status score of >= or a Karnofsky score of >= for subjects >= years of age; Note: Subjects who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score There must be evidence of progression on or after last treatment regimen received. NOTE: If subject is unable to walk due to paralysis, but is mobile in a wheelchair, subject is considered to be ambulatory for the purpose of assessing their performance status. Subjects must have a Lansky performance status score of >= or a Karnofsky score of >= for subjects >= years of age; Note: subjects who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Patients must have a Lansky performance status score of >= , or a Karnofsky score of >= for patients >= years of age; Note: Patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Subjects must have Karnofsky >= %; Note: subjects who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score PART GROUP INCLUSION CRITERIA: Performance status:\r\n* Karnofsky score >= for subjects > years of age\r\n* Lansky score >= for subjects =< years of age\r\n* Note: subjects who are unable to walk because of paralysis, but who are mobile in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score PART GROUP A INCLUSION CRITERIA: Performance status:\r\n* Karnofsky score >= for subjects > years of age\r\n* Lansky score >= for subjects =< years of age\r\n* Note: subjects who are unable to walk because of paralysis, but who are mobile in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score PART GROUP INCLUSION CRITERIA: Performance status:\r\n* Karnofsky score >= for subjects > years of age\r\n* Lansky score >= for subjects =< years of age\r\n* Note: subjects who are unable to walk because of paralysis, but who are mobile in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Patient must have a Lansky performance status score of >= ; Note: patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Patients must have a performance status of , or (Appendix I). Patients who are unable to walk because of paralysis or tumor pain, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Lansky/Karnofsky >= (Lansky for subjects - years; Karnofsky for subjects - years); subjects who are unable to walk because of paralysis, but who are up in a wheelchair will be considered ambulatory for the purpose of assessing the performance score Performance status: Karnofsky >= % for patients > years of age and Lansky >= % for patients =< years of age; subjects who are wheelchair bound because of paralysis will be considered ambulatory when they are up in their wheelchair; subjects have to be able to travel to the NIH for evaluations Patients should have a Karnofsky/Lansky score of greater than or equal to ; patients who require special assistance due to tumor-related paralysis, but who are out of bed during the day will be considered ambulatory for the purpose of calculating the performance score; patients must be able to communicate any symptoms Karnofsky or Lansky performance status (PS): performance status of >= assessed within two weeks prior to registration; neurological deficits in patients must have been relatively stable for a minimum of week prior to study enrollment; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Eastern Cooperative Oncology Group (ECOG) performance status =< (Karnofsky >= %); Note: patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purposes of assessing the performance score Karnofsky >= %; Note: subjects who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Patients should have a life expectancy of at least months and a Karnofsky or Lansky performance score of >= ; patients who are wheelchair bound because of paralysis should be considered ambulatory when they are up in their wheel chair Subjects who are unable to walk because of paralysis, but who are upright in a wheel chair will be considered ambulatory for the purpose of calculating the performance score Performance status: Eastern Cooperative Oncology Group (ECOG) , or , or for children =< years of age, Lansky >= ; note: patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Patients > years of age must have a Karnofsky performance level of >= %, and children =< years old must have a Lansky performance of >= %; patients who are wheelchair bound because of paralysis secondary to a plexiform neurofibroma should be considered ambulatory when they are up in their wheelchair; similarly, patients with limited mobility secondary to need for mechanical support (such as an airway PN requiring tracheostomy or continuous positive airway pressure [CPAP]) will also be considered ambulatory for the purpose of the study Karnofsky performance of >= corresponding to Eastern Cooperative Oncology Group (ECOG) categories , , or ; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Eastern Cooperative Oncology Group (ECOG) =< ; subjects who are wheelchair bound because of paralysis will be considered ambulatory when they are up in their wheelchair; subjects have to be able to travel to the NIH for evaluations