Major surgery within days of study day with the exception of biopsy and insertion of central venous catheter.
DONOR: must have adequate peripheral venous access for leukapheresis or must agree to placement of a temporary central venous catheter
Patients with inadequate bilateral peripheral venous or central venous catheter access for the required apheresis to allow generation of the autologous AdHER DC vaccine product
Adequate venous access for apheresis as assessed by apheresis team; NOTE: If a central venous catheter is required for apheresis, the patient is not eligible
Must have adequate venous access for apheresis; (pheresis catheter placement for cell collection is allowed)
MATCHED RELATED DONOR: Adequate venous access for peripheral apheresis, or consent to use a temporary central venous catheter for apheresis
DONOR: Donor must have adequate peripheral venous catheter access for leukapheresis or must agree to placement of a central catheter
DONOR: Related donors < years of age requiring placement of a leukapheresis catheter will donate peripheral blood collected by phlebotomy (including a unit of blood if weight permits) and shall not undergo catheter placement for leukapheresis
MATCHED RELATED DONOR: Adequate venous access for peripheral apheresis, or consent to use a temporary central venous catheter for apheresis, if applicable
HAPLOIDENTICAL RELATED DONOR: Adequate venous access for peripheral apheresis, or consent to use a temporary central venous catheter for apheresis (if applicable)
DONOR: Adequate venous access for peripheral leukapheresis, or consent to use a temporary central venous catheter for leukapheresis
DONOR: Willing to have a central venous catheter placed for apheresis if peripheral veins are inadequate
DONOR: Capable of undergoing leukapheresis, have adequate venous access, and be willing to undergo insertion of a central catheter should leukapheresis via peripheral vein be inadequate
DONOR: Capable of undergoing leukapheresis, have adequate venous access, and be willing to undergo insertion of a central catheter should leukapheresis via peripheral vein be inadequate
DONOR: Adequate peripheral venous access for apheresis or consent to use a temporary central venous catheter for apheresis; donor selection will be in accordance with National Institutes of Health (NIH)/Clinical Center (CC) Department of Transfusion Medicine (DTM) criteria and, in the case of an unrelated donor, the National Marrow Donor Program (NMDP) standards and Food and Drug Administration (FDA) Code of Federal Regulations (CFR)
Participants unwilling or unable to have a central venous catheter placed will not be excluded from receiving single-agent Doxil
Have a central venous catheter line in place prior to study treatment administration
HAPLO-IDENTICAL DONOR: The donor must have adequate peripheral venous catheter access for leukapheresis or must agree to placement of a central catheter
DONOR: Donor must have adequate peripheral venous catheter access for leukapheresis or must agree to placement of a central catheter
DONOR: Donor must consent to placement of a central venous catheter in the event that peripheral venous access is limited
Patients must consent to an indwelling central venous catheter
DONOR: Donor must have adequate veins for leukapheresis or agree to placement of central venous catheter (femoral or subclavian)
DONOR: Must have adequate veins for leukapheresis or agree to placement of central venous catheter (femoral or subclavian)
Pre-existing functioning central venous catheter
Patients must consent to an indwelling central venous catheter
Unwilling or unable to have a central venous catheter
DONOR: Adequate venous access for peripheral apheresis, or consent to use a temporary central venous catheter for apheresis
DONOR: Capable of undergoing leukapheresis, have adequate venous access, and be willing to undergo insertion of a central catheter should leukapheresis via peripheral vein be inadequate
Has a preexisting functional central venous catheter available for study drug administration
Inpatients who have central venous catheter (CVC) that has been in place for at least days and is expected to remain in place at least for days after enrollment
Patients with multiple co-existing central venous catheters at the time of enrollment will not be enrolled; multiple lumens in a single catheter are acceptable