Serum creatinine < . x ULN; the values must be obtained within hours prior to randomization Creatinine =< . x ULN obtained =< days prior to registration Liver function test must be obtained within days prior to registration Creatinine =< . x ULN (=< days prior to registration) Creatinine =< x ULN obtained =< days prior to registration Obtained =< weeks prior to registration: Total bilirubin =< . x ULN Obtained within days prior to registration: Creatinine < . x upper limit of normal (ULN), OR Obtained within days prior to registration: Bilirubin < . X ULN OBTAINED =< DAYS PRIOR TO REGISTRATION: Total bilirubin =< ULN OBTAINED =< DAYS PRIOR TO REGISTRATION: Creatinine =< . x ULN Creatinine =< x ULN =< days prior to registration Obtained =< days prior to registration: Creatinine =< . x ULN Obtained =< days prior to registration: Total cholesterol =< . x ULN Obtained =< days prior to registration: Triglycerides =< . x ULN Obtained =< days prior to registration: Creatinine =< . x ULN OR Total bilirubin =< . x ULN obtained =< days prior to registration Obtained =< days prior to registration: Direct bilirubin =< . x ULN FOR AML ONLY: Obtained =< days prior to registration: No ANC restriction Creatinine =< . x ULN obtained =< days prior to registration Obtained within days prior to registration; total bilirubin ? ULN Obtained within days prior to registration; serum creatinine ? . x ULN Serum creatinine =< . x ULN, obtained =< days prior to registration Creatinine =< . x ULN (obtained =< days prior to registration) Baseline serum testosterone obtained within days prior to registration Liver function test must be obtained within days prior to registration ARM A: obtained =< days prior to registration: \r\n* Creatinine =< . x ULN ARM A: obtained =< days prior to registration: \r\n* Total bilirubin =< . x ULN ARM B: obtained =< days prior to registration: \r\n* AST/ALT =< . x ULN ARM B: obtained =< days prior to registration: \r\n* Creatinine =< . x ULN ARM B: obtained =< days prior to registration: \r\n* Total bilirubin =< . x ULN ARM B: obtained =< days prior to registration: \r\n* INR =< . x ULN ARM B: obtained =< days prior to registration: \r\n* aPTT =< . x ULN Creatinine =< . x ULN, obtained =< days prior to registration OR Bilirubin =< . x ULN obtained within days prior to registration Potassium =< ULN (or corrected to =< ULN with supplements prior to registration), obtained =< days prior to registration Magnesium =< ULN (or corrected to =< ULN with supplements prior to registration), obtained =< days prior to registration Sodium =< ULN (or corrected to =< ULN with supplements prior to registration), obtained =< days prior to registration Phosphorus =< ULN (or corrected to =< ULN with supplements prior to registration), obtained =< days prior to registration Serum bilirubin . x ULN, obtained within days prior to initiation of study treatment Serum creatinine =< . x ULN, obtained within days prior to initiation of study treatment Obtained =< days prior to registration:\r\nAlkaline phosphatase =< x ULN Obtained =< days prior to registration:\r\nCreatinine =< x ULN All baseline laboratory requirements will be assessed and should be obtained within - days of study registration Serum creatinine =< . x ULN (obtained =< days prior to randomization) Obtained =< days prior to registration: Potassium WNL Obtained =< days prior to registration: Phosphorus WNL Obtained =< days prior to registration: Creatinine =<. x ULN Obtained =< days prior to registration: Creatinine =< . x institutional ULN All subjects must have radiographically assessable disease per RECIST v. obtained by imaging within days prior to registration. Male patients must have free and total testosterone level obtained within days prior to registration Creatinine =< . x Institutional ULN obtained =< days prior to registration Creatinine =< . X ULN obtained =< days prior to registration Creatinine < ULN, performed within days prior to registration