Patients with a history of a serious allergic or anaphylactic reaction to humanized monoclonal antibodies are not eligible History of severe allergic or anaphylactic reactions to monoclonal antibody therapy (or recombinant antibody-related fusion proteins) History of severe allergic or anaphylactic reaction to humanized or murine monoclonal antibodies History of severe allergic or anaphylactic reaction to humanized or murine monoclonal antibodies (for participants receiving regimen including rituximab). Patients with a suspected allergy or sensitivity to any component of MT- drug preparation based upon known allergies to compounds of a similar class who have had an anaphylactic or other severe infusion reaction to human immunoglobulin or monoclonal antibody administration are n ot eligible. History of severe allergic or anaphylactic reactions to monoclonal antibody therapy or a known hypersensitivity to bakers yeast, unless in consultation with an allergy specialist they are deemed eligible for retreatment with desensitization History of Grade anaphylactic reaction to monoclonal antibody therapy. History of severe (defined as grade and/or requiring permanent discontinuation of prior antibody therapy) allergic or anaphylactic reactions to human, humanized, chimeric, or murine monoclonal antibodies History of severe allergic or anaphylactic reactions to previous monoclonal antibody therapy; History of anaphylactic reaction to monoclonal antibody therapy History of anaphylactic reaction to monoclonal antibody therapy History of anaphylactic reaction to human, or humanized, antibody History of severe allergic or anaphylactic reactions to monoclonal antibody therapy History of severe allergic or anaphylactic reactions to monoclonal antibody therapy (eg, subjects in whom re-administration with rituximab would be contraindicated for safety reasons). History of severe allergic or anaphylactic reactions to human monoclonal antibody therapy or known hypersensitivity to any Probody therapeutic. Patients with a history of an anaphylactic reaction to irinotecan. History of anaphylactic reaction to human, or humanized, antibody History of severe allergic or anaphylactic reactions to monoclonal antibody therapy History of severe allergic or anaphylactic reactions to monoclonal antibody therapy History of severe allergic or anaphylactic reactions to previous monoclonal antibody therapy; Subject has prior severe allergic reaction or intolerance to a monoclonal antibody, including humanized or chimeric antibodies. History of grade IV anaphylactic reaction to monoclonal antibody therapy History of allergic or anaphylactic reaction to any therapeutic or diagnostic monoclonal antibody (IgG protein) or molecules made of components of monoclonal antibodies (e.g., Enbrel which is the Fc portion of an antibody or Lucentis which is a Fab) History of ? grade allergic reactions to monoclonal antibody therapy as well as known or suspected allergy or intolerance to any agent given in the course of this trial. Participants with a history of allergic reactions attributed to monoclonal antibody therapy (or recombinant antibody-related fusion proteins) History of anti-drug antibodies, severe allergic, anaphylactic, or other infusion-related reaction to a previous biologic agent History of severe allergic or anaphylactic reactions to monoclonal antibody therapy History of severe allergic or anaphylactic reactions to monoclonal antibody therapy (or recombinant antibody-related fusion proteins) History of a significant allergic reaction attributed to humanized or human monoclonal antibody therapy History of severe allergic or anaphylactic reaction or known sensitivity to humanized or murine monoclonal antibodies History of severe allergic or anaphylactic reactions to monoclonal antibody therapy (or recombinant antibody-related fusion proteins) History of anaphylactic reaction following exposure to humanized or human therapeutic monoclonal antibodies, hypersensitivity to GM-CSF or yeast derived products, clinically meaningful allergic reactions or any known hypersensitivity or prior reaction to any of the formulation excipients in the study drugs. History of severe infusion reactions to monoclonal antibody therapy History of solid organ transplantation and of severe allergic or anaphylactic reaction to humanized, chimeric, or murine monoclonal antibodies History of severe allergic or anaphylactic reactions to monoclonal antibody therapy History of severe (defined as grade and/or requiring permanent discontinuation of prior antibody therapy) allergic or anaphylactic reactions to human, humanized, chimeric, or murine monoclonal antibodies History of severe allergic or anaphylactic reactions to monoclonal antibodies History of severe allergic or anaphylactic reactions to monoclonal antibody therapy History of severe allergic or anaphylactic reactions to monoclonal antibody therapy History of severe allergic or anaphylactic reactions to monoclonal antibody therapy History of severe allergic or anaphylactic reactions to monoclonal antibody therapy or a known hypersensitivity to any of the other study drugs History of allergic reactions to monoclonal antibody therapy (or excipients in the formulation) Previous life-threatening anaphylactic reactions to prior monoclonal antibody-based immunotherapy or any component of the moxetumomab pasudotox formulation Intolerance to rituximab or severe allergic or anaphylactic reaction to any humanized or murine monoclonal antibodies History of severe allergic or anaphylactic reactions to monoclonal antibody therapy History of a significant allergic reaction attributed to humanized or human monoclonal antibody therapy History of severe allergic or anaphylactic reactions to monoclonal antibody therapy (or recombinant antibody-related fusion proteins) Severe allergic or anaphylactic reaction to any monoclonal antibody therapy, murine protein, or known hypersensitivity to any of the study drugs History of a significant allergic reaction attributed to humanized or human monoclonal antibody therapy Transformation of CLL to aggressive B-cell malignancy History of severe allergic or anaphylactic reactions to monoclonal antibody therapy History of severe allergic or anaphylactic reactions to humanized or murine monoclonal antibodies (MAbs, or recombinant antibody-related fusion proteins) or known sensitivity or allergy to murine products History of severe allergic or anaphylactic reactions to monoclonal antibody therapy (or recombinant antibody-related fusion proteins) History of severe allergic or anaphylactic reactions to monoclonal antibody therapy (e.g., patients in whom dosing with obinutuzumab would be contraindicated for safety reasons) History of severe allergic or anaphylactic reactions to human, humanized, or murine monoclonal antibodies Severe hypersensitivity reaction to apixaban, dalteparin, heparin or pork products (e.g., anaphylactic reactions) History of severe allergic or anaphylactic reactions to monoclonal antibody therapy History of severe allergic or anaphylactic reactions to human, humanized or murine monoclonal antibodies Severe hypersensitivity reaction to apixaban (e.g., anaphylactic reactions) History of anaphylactic reactions or severe allergies History of infusion reactions to monoclonal antibody therapies History of infusion reactions to panitumumab or other monoclonal antibody therapies Patients with a history of anaphylactic reactions to OTL History of anaphylactic reaction to human, or humanized, antibody History of infusion reactions monoclonal antibody therapies History of infusion reactions to cetuximab or other monoclonal antibody therapies History of infusion reactions to cetuximab or other monoclonal antibody therapies History of severe allergic or anaphylactic reactions to monoclonal antibody therapy or to the chemotherapy drugs used in this study, unless the antibody can be given through a desensitization program in consultation with an allergist Previous anaphylactic reaction to human, humanized or chimeric antibody History of infusion reactions to cetuximab or other monoclonal antibody therapies Previous anaphylactic reaction to huJ antibody or FDG imaging History of anaphylactic reactions or severe allergies