Patients with a history of congestive heart failure (CHF) or are at risk because of underlying cardiovascular disease or exposure to cardiotoxic drugs must have adequate cardiac function as clinically indicated:\r\n* Corrected QT interval (QTC) =< msec\r\n* Shortening fraction of >= % by echocardiogram or ejection fraction of >= % by gated radionuclide study
Shortening fraction of >= % by echocardiogram, or ejection fraction of >= % by gated radionuclide study
Shortening fraction of >= % by echocardiogram, or
Shortening fraction >= % by echocardiogram, or ejection fraction >= % by gated radionuclide study \r\n* Patients must have an electrocardiogram (EKG) fewer than days prior to enrollment on the dasatinib arm; patients who have had cardiac assessments by echocardiogram or radionuclide scan at the beginning of induction do not need to have these repeated prior to study entry; correct QT interval (QTc) < msec on baseline electrocardiogram as measured by the Frederica or Bazett formula\r\n* No major conduction abnormality (unless a cardiac pacemaker is present)
Shortening fraction of >= % by echocardiogram, or
Shortening fraction of >= % by echocardiogram, or
Shortening fraction of >= % by echocardiogram
Shortening fraction of >= % by echocardiogram (for patients on doxorubicin-containing regimens [Groups C, D, E, and F]), or
Adequate Cardiac Function defined as: Shortening fraction of ? % by echocardiogram, or Ejection fraction of ? % by radionuclide evaluation or echocardiogram.
Shortening fraction of >= % by echocardiogram (while not receiving medications for cardiac function), or
Shortening fraction of >= % by echocardiogram, or ejection fraction of >= % by gated radionuclide study
Within weeks prior to study enrollment: Shortening fraction of >= % by echocardiogram OR
Shortening fraction of >= % by echocardiogram, OR
Shortening fraction of >= % by echocardiogram OR
Shortening fraction > % by echocardiogram or ejection fraction of > % by MUGA
Shortening fraction > % by echocardiogram or
Shortening fraction of >= % by echocardiogram, or ejection fraction of >= % by gated radionuclide study within days prior to enrollment
Echocardiogram must have a shortening fraction or an ejection fraction greater than institutional lower limit of normal for age and gender; echocardiogram must be obtained while patient is not receiving cardiotropic medications (eg., pressors or afterload reducers)
Adequate cardiac function defined as: normal lead electrocardiogram (EKG) with corrected QT interval (QTc) < msec, and either shortening fraction of >= % by echocardiogram and qualitatively normal left ventricular function, or ejection fraction of >= % by echocardiogram
Patient must have normal cardiac function documented by ejection fraction (> %) documented by echocardiogram or radionuclide MUGA evaluation or fractional shortening ( > %) documented by echocardiogram and EKG must demonstrate no abnormality severe enough to justify cardiac medications and baseline QTc interval less than or equal to msecs
Patients with symptomatic cardiac failure unrelieved by medical therapy or evidence of significant cardiac dysfunction by echocardiogram (shortening fraction < %)
Shortening fraction of >= % by echocardiogram
Patients with symptomatic cardiac disease, or evidence of significant cardiac disease by echocardiogram (i.e., shortening fraction < %)
Normal ejection fraction (>= %) documented by either echocardiogram or radionuclide MUGA evaluation OR normal fractional shortening (>= %) documented by echocardiogram
Shortening fraction of >= % by echocardiogram, or
Shortening fraction >= % by echocardiogram or ejection fraction >= % by echocardiogram or radionuclide study
Shortening fraction of >= % by echocardiogram, or
Patients with symptomatic cardiac failure unrelieved by medical therapy or evidence of significant cardiac dysfunction by echocardiogram (shortening fraction < %)
Shortening fraction >= % by echocardiogram, or
Shortening fraction of >= % by echocardiogram, or ejection fraction of >= % by gated radionuclide study
Shortening fraction of >= % by echocardiogram or ejection fraction of >= % by gated radionuclide study
Shortening fraction of >= % by echocardiogram, or ejection fraction of >= % by gated radionuclide study
Shortening fraction of >= % by echocardiogram, or ejection fraction of >= % by gated radionuclide study
Patient with symptomatic cardiac failure unrelieved by medical therapy or evidence of significant cardiac dysfunction by echocardiogram (shortening fraction < %) NOT due to mediastinal mass
For patients on Part B: shortening fraction of >= % by echocardiogram or ejection fraction of >= % by gated radionuclide study
Shortening fraction of >= % by echocardiogram (ECHO) OR
Shortening fraction >= % by echocardiogram
Shortening fraction >= % on screening echocardiogram
Shortening fraction greater than or equal to % by echocardiogram OR
Adequate cardiac function defined as shortening fraction of ? % by echocardiogram or ejection fraction ? % by gated radionuclide study.
NON-PROGRESSED DIPG (STRATUM ): Left ventricular ejection fraction >= by gated radionuclide study OR shortening fraction of >= % by echocardiogram
Shortening fraction of >= % by echocardiogram, or
Cardiac Function: Patient must have a shortening fraction (SF) of > % or an ejection fraction (EF) of > % by echocardiogram or MUGA scan.
Shortening fraction of >= % by echocardiogram
Shortening fraction greater than or equal to % by echocardiogram OR
Shortening fraction of >= % by echocardiogram or ejection fraction >= % by gated radionuclide study
Shortening fraction >= % by echocardiogram or
Shortening fraction of >= % by echocardiogram
Must have electrocardiogram (EKG) with corrected QT (QTc) interval < msec and Echocardiogram with shortening fraction >= % or ejection fraction > %
Shortening fraction greater than or equal to % by echocardiogram; corrected QT interval =< milliseconds
Shortening fraction of >= % by echocardiogram, or if shortening fraction abnormal, ejection fraction of >= % by gated radionuclide study or echocardiogram; note: the echocardiogram or gated radionuclide study must be performed within weeks prior to enrollment
Shortening fraction on echocardiogram > %
Cardiac function: Ejection fraction at rest ? .% or shortening fraction of ? .% by echocardiogram or radionuclide scan (MUGA).
Shortening fraction > % by echocardiogram, or
Shortening fraction of > % by echocardiogram, or