Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Patients with any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol are not eligible Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the investigator's opinion, potentially interfere with the completion of the protocol-specified treatment. Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Other serious medical or psychiatric illness that could potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the Investigator's opinion, potentially interfere with the completion of treatment according to this protocol. Patients with any serious or medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol. Major medical illnesses or psychiatric impairments, which in the investigators opinion will prevent administration or completion of the protocol therapy and/or interfere with follow-up Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of study procedures Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of study procedures Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the investigator's opinion, potentially interfere with the completion of study procedures Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the site investigators opinion, potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the safety monitoring requirements and completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Major medical or psychiatric illness which, in the investigators opinion, would prevent completion of treatment and would interfere with follow up Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of study procedures Patient has poorly controlled hypertension, diabetes mellitus, or other serious medical or psychiatric illness that could potentially interfere with the completion of treatment according to protocol. Patients who have a serious medical or psychiatric illness that could, in the investigator's opinion, potentially interfere with the completion of treatment according to this protocol or may not be able to comply with the safety monitoring requirements of the study Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Non-compliance; a patient has a serious medical or psychiatric illness that could, in the investigator's opinion, potentially interfere with the safety monitoring requirements and completion of treatment according to this protocol Have serious medical or psychiatric illness that could, in the Investigator's opinion, potentially interfere with the completion of treatment according to this protocol. Major medical or psychiatric illnesses which, in the investigators opinion, would prevent completion of treatment and would interfere with follow up Patients must not have any psychiatric illness that could potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the investigator's opinion, potentially interfere with the completion of treatment according to this protocol. Any serious medical or psychiatric illness that could, in the investigator's opinion, potentially interfere with the completion of study procedures or could limit participant expected survival to less than months. Major medical or psychiatric illness which, in the investigators opinion, would prevent completion of treatment and would interfere with follow up Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the investigator's opinion, potentially interfere with the completion of treatment according to this protocol. Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the investigator's opinion, potentially interfere with the completion of study procedures Any serious medical or psychiatric illness that could, in the investigator's opinion, potentially interfere with the completion of treatment Serious medical or psychiatric illness that could, in the investigator's opinion, potentially interfere with the completion of treatment according to the protocol Serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with participation or completion of treatment according to this protocol Patients with any serious medical or psychiatric illness that could, in the investigator's opinion, potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the investigator's opinion, potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol; in particular, a history of a serous psychiatric illness that might be exacerbated by IFN-alpha-b; a history of significant or unstable cardiovascular, hepatic or gastrointestinal disease; a history of autoimmune disease of any kind Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the investigator's opinion, potentially interfere with the completion of treatment according to this protocol. Any life-threatening or serious medical or psychiatric illness unrelated to cancer that could, in the investigator's opinion, potentially interfere with the completion of treatment according to this protocol. Serious medical or psychiatric illness that could, in the investigator's opinion, potentially interfere with the completion of treatment according to the protocol Has serious medical or psychiatric illness that could, in the investigator's opinion, potentially interfere with the completion of treatment according to the protocol Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Patients with any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness, including drug or alcohol abuse, that could, in the investigator's opinion, potentially interfere with the completion of treatment according to this protocol. Other serious medical or psychiatric illness that could potentially interfere with the completion of treatment according to this protocol Any serious medical or psychiatric illness that could, in the investigator's opinion, potentially interfere with the completion of treatment according to this protocol Major medical or psychiatric illness that, in the investigator's opinion, would prevent completion of treatment, completion of the study protocol, or interfere with follow-up Any serious medical or psychiatric illness that could, in the investigators opinion, potentially interfere with the completion of treatment according to this protocol Has any serious medical or psychiatric illness, including drug or alcohol abuse, that could, in the investigator's opinion, potentially interfere with the completion of treatment according to this protocol.