Participants having greater than + proteinuria on urinalysis will undergo -h urine collection for quantitative assessment of proteinuria. Participants with urine protein greater than or equal to g/-hour will be ineligible. Participants with proteinuria >+ on urinalysis will undergo -hour urine collection for quantitative assessment of proteinuria. Participants with urine protein ? g/ hour will be ineligible. Measurable disease M protein component in serum (at least . g/dL) and/or urine (if present) (>=. g excreted in a hour collection sample). Documented baseline proteinuria > mg/day on hour urine collection; only patients with + or greater proteinuria on urinalysis (UA) and a spot urine protein: creatinine ratio of > . will undergo a hour urine collection for quantitation of proteinuria Subjects having > + proteinuria on urine dipstick testing will undergo hours (h) urine collection for quantitative assessment of proteinuria; subjects with urine protein >= g/h will be ineligible If uPCR ? . then a -hour urine collection can be performed to qualify. If this is performed to qualify, the protein result must be < g per hours. > mg/dL on urine analysis; patients with > mg/dL on urine analysis on urine analysis will undergo -hour urine collection for quantitative assessment of proteinuria; subjects with -hour protein >= g/ hours will be ineligible Urinalysis: for patients with + proteinuria on urinalysis, hour urine collection should be obtained; hour urine protein should be < grams If urinalysis shows proteinuria, hour urine collection is to be performed and the hour urine protein is to be < grams to be eligible In patients with metastatic pheochromocytoma, screening urinalysis required prior to study enrollment; if random collection urine specimen is positive for proteinuria, patients must have -hour urine protein determination; patients with metastatic pheochromocytoma are excluded if -hour urine protein is above the institutional upper limit of normal If there is proteinuria present on dipstick, patients must have a hour urine collection; patients are excluded if they have > mg protein on hour urine collection Participants having > + proteinuria on urine dipstick testing will undergo hour urine collection for quantitative assessment of proteinuria. Participants with urine protein ? gram/ hours will be ineligible. Proteinuria at screening demonstrated by urine analysis (UA) > + and hour urine protein >= gram/ hours Subjects having greater than + proteinuria on urine dipstick testing will undergo a -hour urine collection for quantitative assessment of proteinuria. Subjects with a urine protein greater than or equal to g/ hours will be ineligible. Persistent renal involvement from diagnosis with proteinuria (predominantly albumin) > mg/day in a -hour urine collection Clinically significant proteinuria: \r\n* Subjects having > + proteinuria on urinalysis will undergo -hour urine collection for quantitative assessment of proteinuria; subjects with urine protein >= g/-hour will be ineligible Palliative radiation that does not include a target lesion is allowed. Subjects having a spot urine protein:creatinine ratio of > will undergo -hour collection for quantitative assessment of proteinuria. If urine protein > gram/ hours, the subject will be ineligible Subjects having greater than + proteinuria on urine dipstick testing will undergo -hour urine collection for quantitative assessment of proteinuria. Subjects with urine protein greater than or equal to g/-hour will be ineligible. Patients with proteinuria on screening urinalysis confirmed to be > g/ hr by hour urine collection Participants with urine protein ? gram/ hour Measurable disease M component in serum (? . g/dL) and/or urine (? . g excreted in a hour collection sample) Participants having >+ proteinuria on urine dipstick testing will undergo hour urine collection for quantitative assessment of proteinuria. Participants with urine protein ? grams (g)/ hours will be ineligible. If applicable, must be willing to collect a urine specimen and bring to the clinic; depending on specific planned uses, this may be a -hour collection, a -hour fasting collection, or a first morning collection Participants must have a -hour calcium concentration that is =< mg/ hours as measured by -hour urine collection at baseline - Proteinuria < g/ hours based upon hour urine collection or spot urine protein/creatinine ratio - Proteinuria < g/ hours based upon hour urine collection or spot urine protein/creatinine ratio Participants having >+ proteinuria on urine dipstick testing will undergo -hour urine collection for quantitative assessment of proteinuria. Participants with urine protein ? g/ h will be ineligible.