Patients with a history of seizure disorder requiring antiepileptic medication or brain metastases with seizures are NOT eligible for participation Patients with seizure disorder requiring medication Patients with seizure disorder requiring medication Patients with seizure disorder requiring medication Patients with seizure disorder requiring medication Patients who have a history of a seizure disorder requiring anti-seizure medication. History of seizure disorder requiring antiepileptic medication or brain metastases with seizures FOR ALL PHASES (Ib AND II): Patients with seizure disorder requiring medication Patients with seizure disorder requiring medication Seizure disorder requiring medication Patients with seizure disorder requiring medication Patients with seizure disorder requiring medication REGORAFENIB EXCLUSION CRITERIA: Patients with seizure disorder requiring medication Patients with seizure disorder requiring medication Seizure disorder requiring medication Patients with seizure disorder requiring medication (such as steroid anti-epileptics) Patients with seizure disorder requiring medication Patients with seizure disorder requiring medication Patients with seizure disorder requiring medication History of seizure disorder requiring antiepileptic medication or brain metastases with seizures Patients with seizure disorder requiring medication. Patients with seizure disorder requiring medication Patients with seizure disorder requiring medication. Patients with seizure disorder requiring medication Patients with seizure disorder requiring medication Patients with seizure disorder requiring medication Patients with any seizure disorder requiring medication Patients with seizure disorder requiring medication Patients with seizure disorder requiring medication Patients with seizure disorder requiring medication Subjects with seizure disorder currently requiring medication. Have a seizure disorder requiring medication. Patients with seizure disorder requiring medication Patients with seizure disorder requiring medication