Patients who have received prior prostate or pelvic radiotherapy, including external beam or brachytherapy History of radiation therapy, either via external beam or brachytherapy within days prior to registration Any prior or current treatment for prostate cancer, including surgery, radiation therapy (external or brachytherapy) or chemotherapy; Patients who have received prior prostate or pelvic radiotherapy, including external beam or brachytherapy No prior radiation therapy (external beam or brachytherapy) to the pelvis or prostate Patient has received any pelvic radiotherapy (including external beam and/or brachytherapy). Has received any pelvic radiotherapy (including external beam and/or brachytherapy.) Radiation therapy via external beam or brachytherapy within days of registration Current or prior pelvic external beam radiotherapy within years of entry The patient has decided to undergo brachytherapy (or brachytherapy plus external beam radiation) as a treatment modality for his prostate cancer Patient has received any pelvic radiotherapy (including external beam and/or brachytherapy.) Patients should have any of the below to be eligible\r\n* Are not candidates for intracavitary brachytherapy due to poor geometry or poor response to external beam radiation therapy (RT)\r\n* Patients with co-morbid medical conditions, bleeding disorders, poor anesthetic risk precluding brachytherapy\r\n* Patients who refuse brachytherapy or prefer external beam hypofractionated approach\r\n* Patients requiring interstitial brachytherapy\r\n* Note: patients may be discovered during standard therapy and enrolled prior to boost Prior pelvic external beam radiotherapy (EBRT) Patients cannot have previously received pelvic external beam radiation or brachytherapy; patients may be enrolled while undergoing vaginal brachytherapy radiation treatment Patients who have received prior pelvic external beam radiation or brachytherapy will be excluded SUB-STUDY I: Prior pelvic external beam radiation therapy or brachytherapy SUB-STUDY II: Prior pelvic external beam radiation therapy or brachytherapy Prior pelvic external beam radiation therapy or brachytherapy Radiotherapy (external beam irradiation alone or in combination with hormonal therapy and/or brachytherapy) was delivered as definitive therapy for prostate cancer and documentation is available Prior external beam, proton, or brachytherapy to the prostate