Known significant mental illness or other condition, such as active alcohol or other substance abuse or addiction, that in the opinion of the investigator predisposes the subject to high risk of noncompliance with the protocol. A history of substance abuse as defined by version IV of the Diagnostic & Statistical Manual of Mental Disorders (DSM IV). SAFETY RUN-IN: Active substance abuse or psychiatric disorders RANDOMIZED PHASE II CLINICAL TRIAL: Active substance abuse or psychiatric disorders Active substance abuse Known substance abuse or receiving concurrent treatment with non-permitted drugs. History of active ethanol abuse History of alcohol or other substance abuse within the last year. Known significant mental illness or other conditions such as active alcohol or other substance abuse/addiction that, in the opinion of the investigator, predisposes the subject to high risk of noncompliance with the protocol Psychiatric illness, substance abuse History suggestive of substance abuse Patient has alcohol or substance abuse which, in the opinion of the investigator, would interfere with compliance or safety Testing positive on a urine drug screen for drugs of abuse/potential abuse Comorbid conditions that, in the opinion of the investigator, would complicate safety or compliance such as known human immunodeficiency virus (HIV) or current substance abuse Known significant mental illness or other condition such as active alcohol or other substance abuse or addiction that, in the opinion of the investigator, predisposes the subject to high risk of noncompliance with the protocol. Known or suspected substance abuse or alcohol abuse Known significant mental illness or other condition such as active alcohol or other substance abuse or addiction that, in the opinion of the investigator, predisposes the subject to high risk of noncompliance with the protocol. Past or present history of active substance abuse (drug or alcohol) History of active substance or alcohol abuse within the last year History of active substance or alcohol abuse within the last year Known significant mental illness or other conditions such as active alcohol or other substance abuse that, in the opinion of the investigator, predisposes the subject to high risk of noncompliance with the protocol treatment or assessments. Psychiatric disorders and substance (drug/alcohol) abuse History of alcohol or substance abuse Subject has addictive/substance abuse problems. Use of any substance known to cause AME DONOR: Active substance abuse Subject has a documented history of substance abuse (narcotics, alcohol, etc.) or substance dependency in the months prior to baseline data collection Has known psychiatric or substance abuse disorders. Have a history of alcohol of substance abuse, unless in full remission for greater than months prior to the screening visit (day ) when the consent form is signed Active substance abuse History of alcohol or substance abuse, unless in full remission for more than months prior to start of study treatment Donor must not have active alcohol or substance abuse within months of study entry. Recipient must have no active alcohol or substance abuse within months of study entry. Stable, good mental health (e.g., no recent unstable or untreated psychiatric diagnosis, including substance abuse, as determined by the DSM-IV criteria). Self-reported active alcohol or substance abuse within the last days History of substance abuse. Have a current diagnosis of seasonal affective disorder or substance abuse Are in treatment for substance abuse (e.g., illicit drugs, alcohol abuse) History of substance abuse History of substance abuse History of substance abuse Active substance abuse at time of registration (alcohol, drugs, non-prescription use of controlled substances) History of marked anxiety disorder, or history of substance abuse Patients with history of alcohol or substance abuse by using Cut-down, Annoyed, Guilty, Eye-opener adapted to include Drug use questionnaire (CAGE-AID) score of or higher Parents of ALL or AML survivors with a history of a major psychiatric condition that precludes participation (e.g., psychosis, severe depression, active substance abuse) Parent/Caregiver: parents with a history of a major psychiatric condition that precludes participation (e.g., psychosis, severe depression, active substance abuse) Child: survivors with a history of a major psychiatric condition that precludes participation (e.g., psychosis, severe depression, active substance abuse) Breast cancer survivors (BCS) with other major disabling medical, psychiatric, or substance abuse conditions (e.g., anxiety, depression, alcohol/tobacco problems) will be excluded Substance addiction Patients have a known history of seasonal affective disorder or substance abuse Current documented alcohol abuse or illicit drug substance abuse Active alcohol or substance abuse issue Psychiatric conditions, social situations or substance abuse that precludes the ability of the subject to cooperate with the requirements of the trial and protocol therapy Recent extended history of constant-recurrent substance abuse or another medical condition that might compromise safety or the successful completion of the study Subjects with drug, alcohol, or substance abuse reported within the last three years (subject reported); Have a history of alcohol or substance abuse, unless in full remission for greater than months prior to the screening visit (day ) when the consent form is signed With current substance abuse and/or history of substance abuse, as per medical records or patient report Individuals with known or suspected substance abuse, obtained by self-reporting. History of substance abuse Substance abuse within the past years Has a known psychiatric and/or substance abuse disorder that would make it difficult for the participant to cooperate with the requirements of the trial Recent unstable or untreated psychiatric diagnosis including substance abuse, as determined by the Diagnostic and Statistical Manual of Mental Disorders, th edition (DSM-IV) criteria