Ongoing sensory or motor neuropathy Grade ?. No grade >= peripheral motor or sensory neuropathy Neuropathy (sensory and motor) =< CTCAE v . grade Neuropathy (sensory and motor) less than or equal to CTCAE grade Patients must have < grade neuropathy (sensory/motor) within days prior to registration Subject has preexisting sensory or motor neuropathy Grade ? at baseline Participants with grade >= peripheral motor or sensory neuropathy Neuropathy (sensory and motor) NCI CTCAE grade =< Neuropathy (sensory and motor) less than or equal to CTCAE v., grade Patients who have pre-existing motor or sensory neuropathy of a severity ? grade by CTCAE v. criteria Grade ? sensory or motor neuropathy. Has not recovered from adverse reactions to prior myeloma treatment or procedures (chemotherapy, immunotherapy, radiation therapy) to NCI CTCAE less than or equal to (<=) Grade or baseline, except for sensory or motor neuropathy which should have recovered to <=Grade or baseline. Sensory or motor neuropathy ? grade Preexisting motor neuropathy Grade ? Neuropathy (sensory and motor) less than or equal to CTCAE v. grade Sensory or motor neuropathy >= grade Ongoing sensory or motor neuropathy Grade or higher. Sensory or motor neuropathy >= Grade . Neuropathy (sensory and motor) =< to CTCAE grade Patients with symptomatic peripheral motor or sensory neuropathy >= grade at baseline will receive radiation therapy alone Neuropathy (sensory and motor) less than or equal to grade per Common Toxicity Criteria (CTC) version Grade sensory neuropathy or motor neuropathy with pain Sensory/motor neuropathy >= grade Sensory/motor neuropathy >= grade Patients with any of the following adverse events at the time of enrollment are not eligible:\r\n* Grade ? motor, sensory or peripheral neuropathy\r\n* Grade ? hyponatremia (serum sodium [Na] ? mmol/L) Participant must have either no neuropathy (sensory and motor) or neuropathy less than or equal to grade Patients with persistent grade or higher peripheral sensory or motor neuropathy of any cause Sensory or motor peripheral neuropathy >= grade Sensory or motor neuropathy >= grade Subject has preexisting sensory or motor neuropathy Grade ? at baseline Pre-existing >= grade sensory or motor peripheral neurotoxicity Patients must not have a pre-existing > grade motor or sensory neuropathy PHASE II: Patients must not have a pre-existing > grade motor or sensory neuropathy Neuropathy (sensory and motor) =< grade Neuropathy (sensory and motor) less than or equal to CTEP CTCAE version ., grade Pre-existing peripheral motor or sensory neuropathy >= grade Neuropathy (sensory and motor) less than or equal to Grade . Preexisting sensory neuropathy Grade ? or motor neuropathy Grade ? Motor neuropathy considered of autoimmune origin Sensory or motor peripheral neuropathy Neuropathy (sensory and motor) less than or equal to grade Neuropathy (sensory and motor) less than or equal to grade Preexisting sensory and/or motor neuropathy Grade ? History of severe motor or sensory neuropathy, or any other autoimmune disorder which is deemed to be significant CTC Grade or greater neuropathy (motor or sensory) from comorbidity other than prior taxane exposure, such as diabetes. Neuropathy (sensory and motor) less than or equal to CTCAE grade Neuropathy(Both motor and sensory) ? Grade (CTCAE Version .) Neuropathy (sensory and motor) less than or equal to grade Neuropathy (sensory and motor) less than or equal to CTCAE v . grade Patients with pre-existing Grade (or greater) peripheral motor or sensory neurotoxicity per the CTCAE . as determined by the treating physician or a neurologist. Evidence of baseline sensory or motor neuropathy Neuropathy (sensory and motor) =< CTCAE v. grade Significant peripheral sensory or motor neuropathy at the start of the study. Has sensory or motor neuropathy limiting daily activities. Neurologic function: neuropathy (sensory and motor) ? CTCAE Grade Current/ongoing Neuropathy (sensory or motor) Grade > or any history of Grade ? neuropathy with prior Vincristine or chemotherapy exposure (documentation by history is adequate to exclude) Greater than grade motor neuropathy or greater than grade sensory neuropathy at screening Neuropathy (sensory and motor) less than or equal to CTCAE grade Grade or greater motor or sensory neuropathy Patients with >= grade sensory or motor neuropathy are not eligible Neuropathy (sensory or motor) less than or equal to grade Able to perform motor/sensory tests Sensory/motor neuropathy ? Grade Current or prior history of grade ? peripheral sensory and/or motor neuropathy.