Proteinuria Proteinuria + on dipstick analysis or > mg/ hours Has proteinuria Proteinuria: dipstick ?+ Proteinuria greater than grams/ hours. Proteinuria < g/day Proteinuria value > . g at screening Proteinuria dipstick > + or >= gm/ hours Significant proteinuria at baseline (> mg/ h, or > + on spot analysis) Proteinuria >. gm/ hr Proteinuria >+ on urinalysis or > gm/hr. Within - days of study drug administration: Urinalysis no greater than + hematuria or proteinuria No history of medical condition resulting in nephrotic range proteinuria. Proteinuria >+ on urinalysis or > gm/hr. Proteinuria, grade (i.e., >= + proteinuria) Absence of proteinuria Proteinuria < grade Proteinuria > mg/dl on urine analysis Proteinuria =< + on dipstick or =< gram/ hours Proteinuria > gram/ hrs Subject has proteinuria > . gm over hrs are not eligible for the study < + proteinuria No hematuria and/or proteinuria greater than + on urinalysis Patients who have proteinuria CTCAE version (v). grade or greater within < days of registration Grade >= proteinuria at screening (or known prior) Proteinuria < + on dipstick testing (if + seen on first test, retest >= hours later) =< grade hematuria (criteria applicable only for dose levels that include isotretinoin) and =< grade proteinuria Grade or higher proteinuria and hematuria Proteinuria (>= g/ hours) Proteinuria =< + on dipstick or =< gram/ hours Urinalysis with < + proteinuria Significant proteinuria at baseline (>= mg/ hours [h]) Proteinuria < trace Urinalysis with no greater than + hematuria or proteinuria Proteinuria level =< + Proteinuria CTCAE grade or greater Proteinuria less than or equal to + proteinuria on two consecutive dipsticks taken no less than week apart, or a urine protein:creatinine (UPC) ration of =< Patients with history of proteinuria grade >= Proteinuria at screening as demonstrated by urinalysis with proteinuria ? +. Persistent proteinuria of CTCAE grade (>.g/ hours) Urinalysis with < grade proteinuria Subject has proteinuria > . gm over hrs. are not eligible for the study Grade / proteinuria Greater than + proteinuria on two consecutive dipsticks taken no less than week apart Proteinuria > mg/hrs Proteinuria CTCAE grade or greater Patients with + proteinuria/moderate or more at baseline are ineligible Patient must not have known proteinuria >= mg/ hours Greater than + proteinuria on two consecutive dipsticks taken no less than week apart or -hour urine protein of > g; patients with < + proteinuria are eligible following initial determination by urinalysis within week prior to enrollment and do not need the urinalysis repeated >= grade proteinuria