History of congenital long QT syndrome or corrected QT interval (QTc) > msec within weeks of randomization
Participants may not have corrected QT (QTc) > msec or family history of long QT syndrome
Congenital long QT syndrome or corrected QT interval (QTc) > msec
Significant uncontrolled or active cardiovascular disease, specifically including, but not restricted to:\r\n* History of clinically significant (as determined by the treating physician) atrial arrhythmia; or any ventricular arrhythmia\r\n* History of congenital long QT syndrome\r\n* Abnormal QT corrected for heart rate using Bazett's formula (QTcB) (>= msec in males and >= msec in females)\r\n* Ejection fraction =< % as assessed by echocardiogram
Fridericia-corrected QT interval (QTcF) > msec (female) or history of congenital long QT syndrome.
Fredericia-corrected QT interval (QTcF) > msec (female) or > msec (male), or history of congenital long QT syndrome.
Participant with mean resting corrected QT interval (specifically QTc calculated using the Fridericia formula [QTcF]) > msec for males and > msec for females, from electrocardiograms (ECGs) performed within - minutes apart at study entry, or congenital long QT syndrome
History of congenital long QT syndrome or mean (average of triplicate measurements) corrected QT (QTc) measured using Fridericia's method >/= millisecond (ms) at baseline or uncorrectable abnormalities in serum electrolytes (sodium, potassium, calcium, magnesium, phosphorus) Vismodegib
Baseline Fridericia's corrected QT (QTcF) interval greater than msec (female) or greater than msec (male), history of congenital long QT syndrome, the presence in the screening electrocardiography (ECG) of a conduction abnormality that in the opinion of the investigator would preclude safe participation in this study
Any of the following cardiac criteria: Mean resting corrected QTc interval using the Fridericia formula (QTcF) greater than msec/male and greater than msec/female or congenital long QT syndrome
Corrected QT interval (QTc) > msec (as calculated per institutional standards) at study entry or congenital long QT syndrome
Corrected QT (QTc) prolongation > msec (Bazett's formula) or congenitally long QT syndrome
Mean resting corrected QTc interval using the Fridericia formula (QTcF) > msec/male and > msec/female (as calculated per institutional standards) obtained from electrocardiograms (ECGs) - minutes apart at study entry, or congenital long QT syndrome
Corrected QT interval using Fridericia's formula (QTcF) interval of > msec at study entry; congenital long QT syndrome
Corrected QT (QTc) interval (Fridericia formula) > msec for men or > msec for women at study entry; history of congenital long QT syndrome
Patients with resting corrected QT interval (specifically QTc calculated using the Fridericia formula [QTcF]) > msec from a single electrocardiogram (ECG) performed at study entry or congenital long QT syndrome.
QT interval corrected using Fridericia's formula (QTcF) > msec or history of prolonged QT syndrome or Torsades de pointes, or familial history of prolonged QT syndrome.
Patients with congenital long QT syndrome, bradyarrhythmias, or QTc > msec are not eligible
At screening, patients must have no known history of congenital long QT syndrome and must have a corrected mean QTc interval =< msec at baseline
Patients who have a mean resting correct corrected QT (QTc) interval using the Fridericia formula (QTcF) > msec (as calculated per institutional standards) obtained from electrocardiograms (ECGs) - minutes apart at study entry, or congenital long QT syndrome; AZD should not be given to patients who have a history of Torsades de pointes unless all risk factors contributed to Torsades have been corrected; AZD has not been studied in patients with ventricular arrhythmias or recent myocardial infarction
Have Fridericia-corrected QT interval (QTcF) > msec (female) or > (male), or history of congenital long QT syndrome.
Corrected QT (QTc) interval >= msec at baseline or history of congenital long QT syndrome or uncorrectable electrolyte abnormalities
History of congenital long QT syndrome or a corrected QTc interval >= msec at baseline
Prolonged corrected QT (QTc) interval (>= msec) as calculated by Bazetts formula, or patients with a history of congenital long QT syndrome or uncorrectable electrolyte abnormalities
Mean QTc > msec (with Bazetts correction) in screening electrocardiogram or history of familial long QT syndrome
History of congenital long QT syndrome, or a baseline > msec QTcF abnormality (average of the triplicate reading).
Baseline prolongation of QT/corrected QT (QTc) interval, i.e., defined as an average QTc interval > msec calculated using the Fridericia formula for QT correction; long QT syndrome; or the required use of concomitant medication that may cause torsade de pointes
Corrected QT interval (QTc) > msec (as calculated by Fridericia correction formula) at study entry or congenital long QT syndrome.
History of congenital long QT syndrome or mean corrected QTc interval > msec at baseline
Consistent corrected QT (QTc) > msec for men and > msec for women by Fridericia formula, on separate electrocardiograms (ECGs); patients with a history of long QTc syndrome or personal or family history of ventricular arrhythmias will be excluded
History of congenital long QT syndrome or QTc > msec
Have Fridericia-corrected QT interval > milliseconds (msec) (female) or > msec (male), or history of congenital long QT syndrome
Congenital long QT syndrome or QT interval corrected using Fridericia's formula (QTcF) > milliseconds (msec)
Corrected QT (QTc) interval ? msec at baseline or history of congenital long QT syndrome or uncorrectable electrolyte abnormalities. (Patients with well controlled atrial fibrillation are exempt from this criteria.)
Patients must have corrected QT (QTC) interval =< msec on electrocardiogram (EKG) at baseline; patient with congenital long QT syndrome are not eligible
History of, or at risk for, cardiac disease (e.g., long QT syndrome [> msec] or concurrent treatment with any medication that prolongs QT interval).
Corrected QT interval (QTc) > msec (as calculated by Fridericia correction formula) at study entry or congenital long QT syndrome
Patients with history of long QT syndrome, uncorrectable electrolyte abnormalities, or corrected QT (QTc) > msec