Lansky performance status score >= for patients =< years of age Karnofsky performance status score >= for patients > years of age Lansky performance status score >= for patients =< years of age; Karnofsky performance status score >= for patients > years of age Performance status\r\n* Phase I: Karnofsky performance scale (KPS for > years of age) or Lansky performance score (LPS for =< years of age) assessed within one week of enrollment must be >= \r\n* Surgical study: Karnofsky performance scale (KPS for > years of age) or Lansky performance score (LPS for =< years of age) assessed within one week of enrollment must be >= \r\n* Patients who are unable to walk because of neurologic deficits, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score Patients must have a Lansky (? years) or Karnofsky (> years) score of at least Have a Lansky score ? for subjects up to years of age or a Karnofsky score ? for subjects years of age to < years Participants =< - years Lansky -% Performance status Lansky (age < ) or Karnofsky score (age >= ) >= % Karnofsky performance scale ([KPS] for > yrs of age) or Lansky performance score ([LPS] for =< years of age) >= Karnofsky performance scale (KPS for >= years of age) or Lansky performance score (LPS for =< years of age) >= assessed within days prior to registration Lansky Play Scale ? for participants from months up to and including years of age; or Karnofsky score ? for participants > years of age Karnofsky performance scale (KPS for > years of age) or Lansky performance score (LPS for =< years of age) assessed within two weeks of enrollment must be >= Performance status: Lansky Play-Performance Scale ? for children up to and including years of age OR Karnofsky score ? for participants > years of age Performance score > % (use Lansky score for age < and Karnofsky score for age >= ) The participant has a Lansky (< years of age) or Karnofsky (? years of age) performance score of at least . Karnofsky performance scale (KPS for > years [yrs.] of age) or Lansky performance score (LPS for =< years of age) >= assessed within two weeks prior to registration Karnofsky performance status (KPS) of > % (KPS for > years of age) or Lansky performance Score (LPS) of >= (LPS for =< years of age) assessed within weeks prior to registration; patients who are unable to walk because of paralysis but who are up in a wheel chair will be considered ambulatory for the purposes of the performance score Subject has Karnofsky (age ? years) or Lansky (age < years) performance status score ? at screening Karnofsky performance status >= % for patients >= years of age or Lansky play score >= for patients < years of age\r\n* Note: if poor performance status is due to lymphoma - Karnofsky performance status (KPS) >= % or Lansky performance score (LPS) >= is acceptable Performance score of at least % by Karnofsky or performance score (PS) < (Eastern Cooperative Oncology Group [ECOG]) (age >= years), or Lansky play-performance scale of at least % or greater (age < years). Adequate performance status is defined as Karnofsky score >= % (> years of age) or Lansky score >= (pediatrics) Performance level: \r\n* Lansky score >= % (patients < years of age)\r\n* Karnofsky score >= % (patients >= years of age) Karnofsky score of >= for patients > years of age; or Lansky score of >= for patients =< years of age Karnofsky performance status score (age >= years) or Lansky play score (age < years) =< % Adequate performance status is defined as Karnofsky score >= % (>= years of age) or Lansky score >= (pediatrics) Age to years of age with Karnofsky score >= % (>= years) or Lansky score >= (< years) Karnofsky Performance Score (KPS) >= % for patients >= years of age; Lansky score of >= for children < years of age Performance score of at least % by Karnofsky or to by Eastern Cooperative Oncology Group (ECOG) (age >= years), or Lansky Play-performance scale of at least % or greater (age < years) The patient must be in adequate general condition for study, with Lansky or Karnofsky performance score of >= at study entry; Lansky performance scale will be used for patients =< years of age Karnofsky performance scale (KPS for > years of age) or Lansky performance score (LPS for =< years of age) >= assessed within weeks prior to registration Adequate performance status; Lansky score >= % for children < years of age, or Karnofsky score >= % for those > years of age Adequate performance status is defined as Karnofsky score >= % (> years of age) or Lansky score >= (pediatrics) Performance level: Performance score ?%. Karnofsky (for participants > years of age) or Lansky (for participants ? years of age) Patients must have a Lansky (? years) or Karnofsky (> years) score of at least Lansky (=< years) or Karnofsky (> years) score of at least Karnofsky (those years old or older) or Lansky (those younger than years) performance score of at least Subject's Karnofsky performance status (KPS) must be >= % (Eastern Cooperative Oncology Group [ECOG] performance score < ); the Lansky scale will be used for subjects less than years of age and must be >= % Lansky (=< years) or Karnofsky (> years) score of at least Subject has a Karnofsky score of ? % (subjects ? years of age) or a Lansky score ? % (subjects < years of age). Karnofsky performance scale (KPS for > years of age) or Lansky performance score (LPS for =< years of age) assessed within days of enrollment must be >= Lansky (for participants years of age or younger) or Karnofsky (for participants older than years) performance score greater than Karnofsky performance scale (KPS for >= years [yrs] of age) or Lansky performance score (LPS for < years of age) >= assessed within two weeks prior to registration Performance score >= (Lansky for research participants =< years and Karnofsky for those > years) Performance score of >= by Karnofsky or performance score (PS) to (Eastern Cooperative Oncology Group [ECOG]) (age > years), or Lansky play-performance scale >= or greater (age < years) Karnofsky performance scale >= years old (y/o) or Lansky performance score for patients < y/o must be >= assessed within two weeks prior to enrollment Performance Status: Eastern Cooperative Oncology Group (ECOG) score ? (age ?) or Lansky Performance Score (LPS) ?% (age<). If enrolled with primary CNS tumor to be assessed by RANO, Karnofsky Performance Status (KPS) (age ?) or LPS (age<) ? % Patients must have a Karnofsky performance scores (KPS) of at least at the first postoperative visit; patients under years of age must have a Lansky performance score of at least Lansky performance score >= % for patients =< years of age, or Zubrod performance status score of - for patients > years of age Patients must have a Lansky (< years) or Karnofsky (> years) score of at least Karnofsky performance scale (KPS for > years of age) or Lansky performance score (LPS for =< years of age) assessed within two weeks of registration must be >= Performance status: Karnofsky (for participants >/= years of age) or Lansky (for participants < years of age) score of >/= Performance score of at least % by Karnofsky or performance status (PS) < (Eastern Cooperative Oncology Group [ECOG]) (age >= years), or Lansky Play-Performance scale of at least % or greater (age < years) Karnofsky performance status score ? for patients > years of age Lansky performance status score ? for patients ? years of age Patients must have a life expectancy of at least weeks and a Lansky (< years age) or Karnofsky (> years age) score of at least Karnofsky Performance Status >= % for patients years and older and Lansky Play Score >= for patients under years of age Has a Lansky Play Performance score ? (participants ? years of age) or a Karnofsky score ? (participants > years of age) Patients with Lansky (age < years) or Karnofsky (age >= years) score < will be excluded