STEP I: Patients should not have New York Heart Association classification III or IV heart failure or myocardial infarction within the previous  months
Congestive heart failure Class III/IV according to the New York Heart Association (NYHA) Functional Classification.
History of or current Class II, III or IV heart failure as defined by the New York Heart Association (NYHA) functional classification system (Appendix B).
Patient with symptomatic, or history of documented congestive heart failure (NY Heart Association functional classification III-IV);
New York Heart Association Classification II, III, or IV
Heart failure of New York Heart Association Classification III or IV ? months prior to Day 
History of documented congestive heart failure (New York Heart Association functional classification III-IV);
New York Heart Association classification III or IV heart failure
New York Heart Association classification III or IV heart failure
Any other severe, uncontrolled medical condition, including uncontrolled diabetes mellitus (defined as a Hemoglobin AC ? % in subjects with a prior history of diabetes,  days prior to study registration) or unstable congestive heart failure (Stage III-IV of the New York Heart Association Functional Classification)
History of documented congestive heart failure (New York Heart Association functional classification III-IV) within  months prior to initiation of screening
New York Heart Association (NYHA) functional classification I-II
Patients classified according to the New York Heart Association classification as having class III or IV heart disease.
Subjects with a history of heart disease, such as congestive heart failure (class II, III, or IV defined by the New York Heart Association functional classification), history of unstable or poorly controlled angina, or history (<  year prior to enrollment) of ventricular arrhythmia
Class II to IV heart failure as defined by the New York Heart Association functional classification system
In patients with symptoms of congestive heart failure, New York Heart Association (NYHA) classification of grade III or IV
have any other severe, uncontrolled medical condition, including unstable congestive heart failure (Stage III-IV of the New York Heart Association Functional Classification (Appendix III))
New York Heart Association (NYHA) classification IIIB or IV heart failure
Has been classified according to the New York Heart Association classification as having class III or IV heart disease
Class  or  cardiac disease as defined by the New York Heart Association Functional Classification
Class II, III or IV heart failure as defined by the New York Heart Association (NYHA) functional classification system.
Symptomatic congestive heart failure (New York Heart Association classification Il-IV)
class II, III, or IV heart failure as defined by the New York Heart Association (NYHA) functional classification system;
Symptoms of congestive heart failure as defined by the New York Heart Association (NYHA): Functional Classification class III or IV, or medically uncontrolled cardiac rhythm disturbance
Grade  or  cardiac disease as defined by the New York Heart Association Functional Classification
Class II, III, or IV heart failure as defined by the New York Heart Association (NYHA) functional classification system
Patients with a New York Heart Association classification of III or IV
Uncontrolled arterial hypertension or congestive heart failure (New York Heart Association Classification  or ) (Appendix B).
Have clinical symptomatic congestive heart failure defined at >= Class II of the New York Heart Association functional classification system or LVEF < % at baseline.
Patients that have been designated Class III or IV by the New York Heart Association Functional Classification.
Class  or  cardiac disease as defined by the New York Heart Association Functional Classification
New York Heart Association classification III or IV heart disease
Congestive heart failure (CHF), grade III or IV per New York Heart Association (NYHA) classification
New York Heart Association Functional Classification of Heart Failure: Class III or IV (Appendix ).
New York Heart Association classification III or IV
New York Heart Association classification III or IV
New York Heart Association classification III or IV
Participants classified according to the New York Heart Association classification as having class III or IV heart disease
New York Heart Association classification III or IV
New York Heart Classification III or IV heart disease (see Appendix G).  Other severe\n             cardiovascular or cardiopulmonary disease, including COPD
Patients should not have New York Heart Association classification III or IV heart failure
Subject with Class III or IV Congestive Heart Failure as defined by the New York Heart Association (NYHA) functional classification system within the previous  months.
New York Heart Association Classification II, III, or IV (see APPENDIX D)
History of documented congestive heart failure (New York Heart Association functional classification III-IV)
Subjects with clinically significant heart disease, such as congestive heart failure (class II, III, or IV defined by the New York Heart Association functional classification), history of unstable or poorly controlled angina, or history (<  year) of ventricular arrhythmia
. Class III or IV heart failure as defined by the New York Heart Association functional classification system up to  months before Cycle , Day .
Has any other severe, uncontrolled medical condition, including unstable congestive heart failure (Stage III-IV of the New York Heart Association Functional Classification) or has a known or suspected allergy to the study drug or any study drug component.
New York Heart Association classification III or IV heart failure
Grade  or  cardiac disease as defined by the New York Heart Association Functional Classification
History of documented congestive heart failure (New York Heart Association functional classification III-IV)
Patients with class II, III, or IV heart failure as defined by the New York Heart Association (NYHA) functional classification system\r\n* Abnormal cardiac valve morphology (subjects with minimal abnormalities, can be entered on study with approval)
Evidence of current Class II, III, or IV heart failure as defined by the New York Heart Association [NYHA, ] functional classification system at the time of transition to this study.
Class II, III, or IV heart failure as defined by the New York Heart Association (NYHA) functional classification system at the time of transition to this study
Uncontrolled arrhythmias; any Class - cardiac diseases as defined by the New York Heart Association (NYHA) functional classification
Has decompensated congestive heart failure as defined by New York Heart Association (NYHA) functional classification III or IV
Severe cardiovascular disease; New York Heart Association (NYHA) functional classification >= 
Congestive heart failure ? Class  based on New York Heart Association Functional Classification
Grade  or  cardiac disease as defined by the New York Heart Association Functional Classification
New York Heart Association Classification III or IV
History of, or current, documented congestive heart failure (New York Heart Association functional classification III - IV), documented cardiomyopathy.
New York Heart Association classification III or IV congestive heart failure
History of any clinically significant cardiovascular disorder (i.e., symptoms above Class II per New York Heart Association [NYHA] Functional Classification);
New York Heart Association Classification III or IV
New York Heart Association Classification II, III, or IV
New York Heart Association Classification III or IV (see Appendix F)
A New York Heart Association (NYHA) classification of IV.
Class II, III, or IV heart failure as defined by the New York Heart Association (NYHA) functional classification system
New York Heart Association Classification III or IV (see Appendix E)
New York Heart Association classification III or IV
New York Heart Association (NYHA) classification III or IV heart failure (see Appendix G) despite medical management
Class II or greater congestive heart failure as described in the New York Heart Association Functional Classification criteria
New York Heart Association (NYHA) classification III or IV congestive heart failure
Cardiac failure, New York Heart Association (NYHA) Class II according to the NYHA Functional Classification,
Class II, III, or IV heart failure as defined by the New York Heart Association functional classification system.
New York Heart Association (NYHA) classification III or IV heart disease
Has Class III or IV heart failure as defined by the New York Heart Association (NYHA) functional classification system.
New York Heart Association functional classification for congestive heart failure (NYHA CHF) < 
New York Heart Association (NYHA) classification I or II
New York Heart Association Classification III or IV heart
No current New York Heart Association classification II, III, or IV congestive heart failure
New York Heart Association classification III or IV heart failure
Subjects with classification of  or higher heart failure as classified by the New York Heart Association (NYHA)
Patient has congestive heart failure Class III/IV according to the New York Heart Association (NYHA) Functional Classification
Class II to IV heart failure as defined by the New York Heart Association functional classification system
Congestive heart failure (New York Heart Association functional classification III-IV)
Patient with known Class III/IV congestive heart failure according to the New York Heart Association classification
History of congestive heart failure (CHF) Class III/IV according to the New York Heart Association (NYHA) Functional Classification or serious cardiac arrhythmias requiring treatment.
History of documented congestive heart failure (New York Heart Association functional classification III-IV).