Patients must have an estimated survival greater or equal to months Participants with active infection(s) for which they are receiving drug treatment unless the clinical status is judged to be stable and survival is estimated to be at least weeks ECOG performance status of - and estimated survival of at least months Estimated survival of at least weeks; Patients must have at least one of the following for a diagnosis/disease status:\r\n* Unresectable disease\r\n* Metastatic disease\r\n* Medically unfit for surgical resection but with an expected survival of > months, Eastern Cooperative Oncology Group (ECOG) < and New York Heart Association (NYHA) status =< II\r\n* Disease where no conventional therapy leads to a survival benefit > months in the respective cohort and line of therapy for which the patient is otherwise eligible\r\n* Actionable alterations determined by FoundationOne Presence of any other medical complication that implies survival of less than six months For known primary, disease-specific graded prognostic assessment (ds-GPA) estimated median survival no less than months For unknown primary, graded prognostic assessment (GPA) estimated median survival no less than months Patients who have a known primary and have an estimated median survival less than months per ds-GPA Patients who have an unknown primary and have an estimated median survival less than months per GPA Estimated survival >= months Participants with a serious medical illness that may limit survival to less than months No known Food and Drug Administration (FDA) -approved therapy available that is expected to prolong survival by greater than months Predicted survival of > months Surgeon's estimated survival >= month Estimated survival < month Patients with an estimated survival of less than three months. Estimated survival of at least weeks Estimated survival of at least months Patients must have a reasonable expectation of ? months survival Estimated survival ? months. An estimated progression-free survival of less than one year Survival expectation of weeks or longer after starting study drug Similar condition with an expectation of > % five-year disease-free survival Survival expectation of weeks or longer after starting study drug. Patients must have an estimated survival greater than or equal to months Presence of any other medical complications that imply a survival of less than six months No known Food and Drug Administration (FDA)-approved therapy available thats expected to prolong survival by greater than months Patients with an estimated survival of less than one year are not eligible Have a -year survival rate of % or greater as deemed by their oncologist, surgeon, or other relevant attending physician (suggesting a reasonable rate of cure or prolonged medical survival with state-of-the-art medical care). Survival less than months after surgery (either predicted survival before surgery or actual survival after surgery < months) Patients with an ECOG performance status of , , or , and estimated survival of > weeks. If survival is deemed less than months for any medical condition Estimated survival of at least months. Patient may have distant metastatic disease provided the estimated survival is at least year