COHORTS  AND : HEALTHY VOLUNTEERS: Males and females aged - years
COHORTS  AND : HEALTHY VOLUNTEERS: Subjects must participate fully and be willing to comply with the procedures of the protocol
COHORTS  AND : HEALTHY VOLUNTEERS: Subjects must be co-enrolled in National Institutes of Health (NIH) protocol -HG-
COHORTS  AND : HEALTHY VOLUNTEERS: Ability of subject to understand and provide written informed consent
COHORTS  AND : HEALTHY VOLUNTEERS: Access to bathing facilities (Cohort )
COHORTS  AND : HEALTHY VOLUNTEERS: Ability to swallow capsules or tablets
COHORTS  AND : HEALTHY VOLUNTEERS: Does not meet inclusion criteria
COHORTS  AND : HEALTHY VOLUNTEERS: Any female with symptoms and/or serum hormone levels consistent with perimenopause
COHORTS  AND : HEALTHY VOLUNTEERS: Use of systemic antibiotics in  months preceding baseline sampling
COHORTS  AND : HEALTHY VOLUNTEERS: Use of swimming pools, hot tubs, or whirlpools in  days preceding baseline sampling
COHORTS  AND : HEALTHY VOLUNTEERS: Use of topical or oral complementary/alternative medicine (CAM) agents within  weeks of initiation of treatment
COHORTS  AND : HEALTHY VOLUNTEERS: Known allergic reaction to sulfa, beta-lactam, or tetracycline class drugs; or lidocaine or epinephrine
COHORTS  AND : HEALTHY VOLUNTEERS: Family history of toxic epidermal necrolysis
COHORTS  AND : HEALTHY VOLUNTEERS: Known allergy or sensitivity to sodium hypochlorite (NaOCl)
COHORTS  AND : HEALTHY VOLUNTEERS: History of AD and asthma
COHORTS  AND : HEALTHY VOLUNTEERS: Inability to comply with the requirements of the protocol
COHORTS  AND : HEALTHY VOLUNTEERS: Pregnant or lactating
COHORTS  AND : HEALTHY VOLUNTEERS: Subjects with a primary or acquired immunodeficiency, including human immunodeficiency virus (HIV) seropositivity
COHORTS  AND : HEALTHY VOLUNTEERS: Any chronic past or present medical illness, including chronic skin diseases like psoriasis
COHORTS  AND : HEALTHY VOLUNTEERS: Subjects receiving or planning to receive an investigational new drug (IND) agent, ultraviolet light therapy, monoclonal antibodies, or systemic immunosuppressants
LGBT SUB-STUDY: Participants are healthy volunteers currently living in San Diego Portland, or Albuquerque who attend bars or nightclubs in the LGBT random sample; both current (past  day) smokers and nonsmokers will be included in the focus groups and surveys
Normal volunteers, either male or female
Healthy volunteers and normal patients not undergoing endoscopy
EXCLUSION - HEALTHY VOLUNTEERS: Prior or current malignancy
EXCLUSION - HEALTHY VOLUNTEERS: Known kidney disease
For healthy volunteers only: Must have no known medical problems that would make undergoing the scan hazardous to the health of the patient or interfere with the results. In particular subjects should not have any cardiac or immunological disorders as these would likely affect the scan results. Subjects should have had a full physical exam within  months of the study. If healthy volunteers have not had a full medical exam within  months of the study, one of the nuclear medicine physicians will conduct the medical exam prior to any study procedures.
CRITERIA FOR HEALTHY VOLUNTEERS: Subject meets all criteria above but does not have a clinical diagnosis of respiratory disease
Healthy volunteers for the Dosimetry Studies Arm must not\r\n* Have a history of cardiopulmonary conditions requiring any treatment or medical intervention\r\n* Be a current smoker
Participants/volunteers with a pacemaker, aneurysm clip, or any other condition that would warrant avoidance of a strong magnetic field
Participants/volunteers who are unable to comply or complete the MRI exam due to claustrophobia or high levels of anxiety
HEALTHY VOLUNTEERS (Group ): Must meet inclusion criteria for all participants described above
Healthy volunteers
NORMAL ADULT VOLUNTEERS
PATIENT VOLUNTEERS
PATIENT VOLUNTEERS/CONTRAST ENHANCEMENT SUB-GROUP
Patient Volunteers/Contrast Enhancement Sub-group: Not pregnant or breast-feeding
Patient Volunteers/Contrast Enhancement Sub-group: Ability to lie motionless for up to  minutes
NORMAL ADULT VOLUNTEERS:
PATIENT VOLUNTEERS:
PATIENT VOLUNTEERS/CONTRAST ENHANCEMENT SUB-GROUP:
Patient Volunteers/Contrast Enhancement Sub-group: Positive urine pregnancy test or currently breast-feeding
HEALTHY VOLUNTEERS: Patient is willing to provide informed consent
HEALTHY VOLUNTEERS: Must have no known medical problems and have had a full medical exam within  months of the study; if healthy volunteers have not had a full medical exam within  months of the study, one of the ultrasound physicians will conduct the medical exam prior to any study procedures
Normal volunteers
HEALTHY VOLUNTEERS: Age greater than or equal to 
HEALTHY VOLUNTEERS: Able to tolerate supine position
Healthy volunteers
PART A: Healthy volunteers enrolled from within the Department of Radiology at University of California San Francisco (UCSF)
NORMAL VOLUNTEERS: Be >=  years of age
NORMAL VOLUNTEERS: Have a ECOG performance status of -
NORMAL VOLUNTEERS: Be informed of the investigational nature of this study
NORMAL VOLUNTEERS: Have electrically, magnetically, or mechanically activated implants that would preclude MRI
NORMAL VOLUNTEERS: Be using more than one antihypertensive drug
NORMAL VOLUNTEERS: If female, pregnant or breastfeeding at time of consent
NORMAL VOLUNTEERS: Have collagen vascular disease
NORMAL VOLUNTEERS: Currently treated for hyperthyroidism
NORMAL VOLUNTEERS: Be receiving any active pharmaceutical treatments for cancer
Healthy volunteers