[c09aa8]: / clusters / 9knumclustersv2 / clust_2854.txt

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Treatment with systemic corticosteroids > mg/day, prednisone or equivalent
Subject with Graft vs. Host Disease (GVHD) who is receiving treatment with systemic glucocorticoids > mg/day equivalent of prednisone; however, treatment with low dose glucocorticoids (? mg/day equivalent of prednisone) is permitted
Any immunomodulatory drug therapy, anti-neoplastic hormonal therapy (unless dose has been stable for months prior to Baseline and will remain stable during the trial), immunosuppressive therapy, corticosteroids > mg/day prednisone or equivalent, or growth factor treatment (e.g., erythropoietin) within days prior to initiation of study drug.
Any prednisone (or equivalent corticosteroids) use within weeks of study entry
Subjects receiving immunologically based treatment for any reason, including chronic steroids or prednisone (at dose > mg/day of prednisone) within day prior to first study treatment; inhaled or topical steroids or systemic steroids (at dose =< mg/day of prednisone) is permitted
Treatment with systemic corticosteroids ? mg/day prednisone or equivalent, for non-lymphoma treatment reasons. For lower acceptable doses, documentation of a stable dose for at least weeks prior to Day of Cycle is required.
Any other concurrent investigational agent or chemotherapy, radiotherapy, immunotherapy, or corticosteroids (prednisone up to mg/day or its equivalent is permitted for chronic conditions)
Systemic glucocorticoid therapy (prednisone > mg/day orally or equivalent) within the last weeks prior to first dose, unless tapered and on a stable dose (prednisone ? mg/day orally or equivalent) for at least week.
Previously untreated; NOTE: this includes any chemotherapy or immunotherapy or RIT; patients who received corticosteroids for diseases other than lymphoma are eligible as long as prednisone dose is =< mg/day
Systemic corticosteroids greater than the equivalent of mg of prednisone per day within weeks of study drug administration are prohibited
Systemic steroids that have not been stabilized to the equivalent of =< mg/day prednisone prior to the start of the study drugs
Prior treated CNS metastases must be without MRI evidence of recurrence for at least weeks after treatment; patients must be off immunosuppressive doses of systemic steroids (>= mg/day prednisone or equivalent) for at least days prior to study drug administration, and must have returned to neurologic baseline status postoperatively\r\n* The -week period of stability is measured after the completion of the neurologic interventions (ie, surgery and/or radiation)
Immunosuppressive treatments within weeks prior to embolization, unless prednisone ? mg or equivalent
Patients that require decadron > mg/ day or equivalent of steroids.
Patients may be on steroids prior to initiation of treatment, provided that, by cycle day , steroid use is tapered down to less than or equal to mg/day of prednisone
The subject is off corticosteroids of > mg/day prednisone or equivalent.
No concurrent treatment for the CNS disease (e.g. surgery, radiation, corticosteroids > mg prednisone/day or equivalent)
Treatment with systemic corticosteroids (> mg per day prednisone or equivalent) or other immune suppressive drugs within weeks
Received a cumulative dose of corticosteroids equivalent to greater than or equal to ( >=) milligram (mg) of prednisone within the -day period before the first dose of study drug
If patient is currently on prednisone or other corticosteroids for palliation, the dose must be less than or equal to mg a day or its equivalent dose and it must have been started at least weeks prior to cycle day
Systemic therapy with corticosteroids at > mg/day prednisone or equivalent within week prior to the first dose of study drug
The following medications are prohibited within weeks of enrollment and while on study drug:\r\n* alpha-reductase inhibitors (finasteride, dutasteride)\r\n* Biologic or other agents with anti-tumor activity against prostate cancer (excluding herbal supplements)\r\n* Systemic glucocorticoids greater than the equivalent of mg per day of prednisone\r\n** Premedication with systemic glucocorticoids greater than the equivalent of mg per day of prednisone is permitted prior to docetaxel infusions\r\n* Androgens (testosterone, dehydroepiandrosterone [DHEA], etc.)
Subjects who are currently using more than mg/day of prednisone (or an equivalent glucocorticoid exceeding physiologic replacement levels)
Patients who take any immune or bone marrow suppressive agents including any systemic corticosteroid that exceed an equivalent of mg prednisone per day within weeks from the study treatment. Inhalation or topical steroids are allowed.
Received a cumulative dose of corticosteroids equivalent to greater than or equal to (>=) milligram (mg) of prednisone within the -day period before the first dose of study drug
Subject has received a cumulative dose of corticosteroids more than the equivalent of >= mg of prednisone within the week period before cycle , day
No use of systemic steroids greater than the equivalent of mg of prednisone/prednisolone per day within weeks prior to enrollment
Patients with treated, non-progressive brain metastases, off high-dose steroids (> mg prednisone or equivalent) for at least weeks can be enrolled in the trial.
Prednisone dose =< mg/day and off all other systemic immunosuppressive medications for at least weeks prior to study entry
Patients may be on steroids prior to initiation of treatment, provided that, by cycle day , steroid use is tapered down to less than or equal to mg/day of prednisone
Brain metastases that are clinically unstable (e.g. showing unequivocal growth on imaging, requiring radiation therapy, or steroids >mg of prednisone equivalent) within weeks of first dose of study drug.
Human immunodeficiency virus (HIV)-positive patients, patients with acquired or congenital immunodeficiency conditions, those on chronic systemic immunosuppressants (requiring > mg of prednisone or equivalent/day), those with active autoimmune disease are excluded from the study
Chronic use (> weeks) of corticosteroids (prednisone >= mg/ hour [hr] equivalent) within weeks of screening
No prior treatment except a prior limited-field radiotherapy, a short course of glucocorticoids =< mg daily of prednisone equivalent which must cease prior to day of cycle , and/or cyclophosphamide for an urgent lymphoma related problem at diagnosis (e.g. epidural cord compression, superior vena cava syndrome)
Unstable, symptomatic brain metastases; Note: participants whose symptoms are controlled on a stable dose of corticosteroids (=< mg prednisone equivalent per day) for at least weeks will be eligible
At least weeks from prior therapy to time of start of treatment; prior therapy includes steroids (except prednisone or equivalent - up to mg per day is allowed)
Patients receiving systemic steroids ? mg/day of prednisone or the equivalent
Receiving corticosteroids > mg of prednisone per day (or equivalent); Note: the dose should be noted on the medication record each cycle
No autoimmune disease or chronic steroids (dose of > mg/day prednisone equivalent) or other immunosuppressive medications within days of randomization (for MSI-H nivolumab group)
Receipt of systemic cancer therapy, immunomodulatory drug therapy, immunosuppressive therapy, or corticosteroids > mg/day prednisone or equivalent within days prior to the Baseline Visit or concurrently during the trial.
Patients who are currently receiving chronic (> days) treatment with corticosteroids at a dose >= mg of prednisone (or its glucocorticoid equivalent) per day, or any other chronic immunosuppressive treatment that cannot be discontinued prior to starting study drug
Regular treatment with corticosteroids during the weeks prior to the start of cycle , unless administered for indications other than NHL at a dose equivalent to =< mg/day prednisone
If receiving corticosteroids, ? mg/day prednisone or equivalent and unchanged
Receiving corticosteroids above physiological dosing (> mg per day of prednisone) within days prior to anti-CD-CAR-transduced T cell administration
Ability to be off prednisone and other immunosuppressive drugs (< mg/day) for at least days prior to and while receiving ALT-
Patients on systemic corticosteroids (> mg prednisone per day or equivalent) or other systemic immunosuppressive drugs
Prednisone dose ? mg/day
Patients receiving systemic steroids ? mg/day of prednisone or the equivalent
Treatment with corticosteroids (? mg per day prednisone or equivalent) or other immune suppressive drugs within the days prior to the initiation of study drug administration.
Ongoing corticosteroids for indications other than multiple myeloma allowed as long as the dose does not exceed mg of prednisone per day or equivalent
Chronic use (? weeks) of corticosteroids (? mg/ hour equivalent prednisone) within weeks of Baseline/Cycle Day visit.
Patients with a history of severe immune-mediated adverse reactions with ipilimumab: this will be defined as any grade toxicity requiring treatment with corticosteroids (greater than mg/day prednisone or equivalent dose) for greater than weeks
Patients must not be receiving concurrent steroids > mg prednisone (or equivalent)\n per day.
Systemic corticosteroids within weeks, except low dose regimens (prednisone, ? \n mg/day, or equivalent) which may continue if unchanged
No corticosteroids are permitted, except for maintenance therapy for a non-malignant disease or to prevent treatment-related ofatumumab reactions (maintenance therapy dose must not exceed mg/day prednisone or equivalent)
Patients must have completed prednisone taper ( mg - . mg) prior to randomization
Prior systemic glucocorticosteroid use for the treatment of non-malignant disorders is permitted; concurrent use after registration on the study should be restricted to the equivalent of prednisone mg per day
Systemic therapy with corticosteroids at > mg/day prednisone or equivalent within week prior to the first dose of study drug
Subject received treatment with systemic glucocorticoids greater than the equivalent of mg per day of prednisone within weeks prior to day , intended for the treatment of prostate cancer.
Glucocorticoid therapy (prednisone > mg/day or equivalent) within days prior to study day
Regular treatment with corticosteroids within the or weeks prior to the start of Cycle , unless administered for indications other than non-Hodgkin's lymphoma at a dose equivalent to < mg/day prednisone/prednisolone
Patients must not be receiving chronic treatment (equivalent of prednisone > mg/day) with systemic steroids or other immuno-suppressive agent
No prior anti-lymphoma therapy. However, for subjects with bulky disease,systemic symptoms, compressive disease, or rapidly progressing adenopathies, pre-phase treatment with mg/kg/day prednisone, or equivalent, for a maximum of days is permitted prior to Cycle Day - at the discretion of the Investigator. In exceptional cases, if clinically indicated, a higher dose of steroids and/or a slightly longer duration is allowed for the purpose of urgent symptom management, and the subjects is considered eligible. A washout period does not apply. However the fresh core biopsy mentioned above should be performed before starting prednisone.
Chronic use (? weeks) of corticosteroids (? mg/ hr equivalent prednisone) within weeks of Baseline/First Dose.
Received any chemotherapy, immunomodulatory or immunosuppressive therapy, corticosteroids (greater than [>] milligram per day [mg/day] prednisone or equivalent) within days prior to randomization
Patients receiving concomitant immunosuppressive agents or chronic corticosteroids (? mg of prednisone or equivalent) at the time of first study dose.
Patients who are currently receiving chronic (> days) treatment with corticosteroids at a dose equal to or more than mg of prednisone (or its glucocorticoid equivalent) per day, or any other chronic immunosuppressive treatment that cannot be discontinued prior to starting study drug
Subjects taking corticosteroids during the last week prior to study treatment, unless administered at a dose equivalent to < mg/day prednisone or prednisolone.
Use of prednisone (or equivalent corticosteroid dose) for SM up to mg/day or its equivalent is allowed, but it cannot have been started during screening; patients who are on prednisone up to mg/day for medical problems unrelated to SM are also permitted on study
Have received corticosteroids greater than (>) milligram per day (mg/day) prednisone or equivalent, or growth factor treatment within weeks prior to study entry
Participants using concomitant corticosteroids are allowed as long as the subject is on the equivalent of mg/day or less of prednisone and has been on a stable dose for at least two weeks prior to initiating therapy
Ongoing treatment with chronic immunosuppressants (eg, cyclosporine) or systemic steroids > mg prednisone (or equivalent) QD
No chronic use of systemic steroids greater than the equivalent of mg of prednisone/prednisolone per day within weeks prior to enrollment
Use of systemic steroids at an equivalent dose of prednisone mg/day or higher at randomization
Current treatment with immunosuppressive agents other than prescribed corticosteroids (not more than -mg prednisone equivalent).
Systemic steroids that have not been stabilized to the equivalent of =< mg/day of prednisone days prior to the initiation of the trial
Oral corticosteroids >= . mg/day prednisone (or prednisone equivalents)
Patient on corticosteroids within two weeks prior to study entry, except for prednisone < = mg/day or equivalent for purposes other than treating MCL.
Chronic systemic steroids (> mg/day Prednisone equivalents) or any other immunosuppressive agents
Patients cannot have evidence of immunosuppression or have been treated with immunosuppressive therapy, such as chemotherapy or chronic treatment dose corticosteroids (greater than the equivalent of mg prednisone per day), within months of the first vaccination; treatment or salvage radiation therapy must have been completed at least weeks prior to the first vaccination
Receiving corticosteroids > mg of prednisone per day (or equivalent)
Any condition requiring chronic use of moderate/high dose steroids (equivalent to mg QD prednisone).
Chronic use of systemic corticosteroids (i.e., >= mg/day prednisone or equivalent)
Receipt of systemic corticosteroids within weeks of study treatment, unless patient has been taking a continuous dose of mg/day or less of oral prednisone or equivalent for at least weeks or as part of a CHOP prednisone taper.
Able to be off prednisone or other immunosuppressive medications for at least days prior to Day (excluding pre-medications); low dose prednisone (< mg/day) is allowed if for indication other than graft-versus-host disease (GVHD)
Has, within weeks prior to Day , received systemic corticosteroids exceeding prednisone mg per day or equivalent; for other immunosuppressive agents, the exclusionary dose and duration will be determined in consultation with the Medical Monitor.
Concurrent use of other anti-cancer agents or treatments. NOTE: Growth factors and bisphosphonates are allowed as medically indicated. Steroids may be used with an equivalency of up to mg of Prednisone per day as long as the dose has not been adjusted upwards in past weeks prior to study registration.
Prior treated CNS metastases must be without MRI evidence of recurrence for at least weeks after treatment. Patients must be off immunosuppressive doses of systemic steroids (? mg/day prednisone or equivalent) for at least days prior to study drug administration, and must have returned to neurologic baseline status postoperatively. The -week period of stability is measured after the completion of the neurologic interventions (ie, surgery and/or radiation).
On immunosuppressive or other anti-leukemic therapy, excluding patients receiving glucocorticoids for management of circulating blast count or patients on a stable dose (<mg/m/day prednisone or equivalent) of systemic or topical glucocorticoid therapy with ? Grade GvHD or tapering dose of calcineurin inhibitor
Glucocorticoid therapy (prednisone > mg/day or equivalent within days of first dose)
Treatment with oral steroids (dose ? mg/day of methylprednisolone or equivalent)
Glucocorticoid therapy (prednisone > mg/day or equivalent) within days prior to randomization
Use of systemic steroids at an equivalent dose of prednisone mg/day or higher within weeks of day of protocol therapy
Glucocorticoid therapy (prednisone > mg/day or equivalent) within the last three weeks
Low-dose corticosteroids (prednisone < mg/ day or equivalent dose) are permitted throughout study.
High-dose corticosteroids (prednisone ?mg/day or equivalent dose) must be discontinued ? days of initiating therapy.
Subject has received a cumulative dose of corticosteroids more than the equivalent of >= mg of prednisone within the week period before cycle , day
Glucocorticoid therapy (prednisone > mg/day or equivalent) within days prior to randomization.
Glucocorticoid use, unless given in doses less than or equal to mg/Day prednisone (or equivalent) for less than Days for exacerbations other than CLL (e.g. asthma).*
Regular treatment with corticosteroids within the weeks prior to the start of Cycle , unless administered for indications other than NHL at a dose equivalent to < mg/day prednisone/prednisolone
Patients receiving high dose opioids on a chronic basis (greater than or equivalent to mg of morphine per day)
Ongoing treatment with corticosteroids with a dose > milligram (mg) prednisone or equivalent per day at the time of randomization; or > mg cumulative prednisone dose or equivalent for any -week period in the year prior to randomization
Treatment with systemic immune modulators including, but not limited to, nontopical systemic corticosteroids (unless the dose is ? mg/day prednisone or equivalent), cyclosporine, and tacrolimus within weeks before study day
Subjects with a condition with anticipated use of systemic steroids above the equivalent of mg prednisone are excluded.
Corticosteroids are allowed, but must be dosed at prednisone mg (or equivalent) or lower prior to the start of chemotherapy