Patients who are human immunodeficiency virus (HIV) positive on highly active anti-retroviral therapy (HAART) will be excluded from the study Patients known to be human immunodeficiency (HIV)-positive receiving anti-retroviral therapy are excluded from the study Not compliant with anti-retroviral therapy (HIV infected participants) Human immunodeficiency virus (HIV)-positive patients receiving anti-retroviral therapy are excluded from this study; HIV positive patients not receiving antiretroviral therapy are excluded Human immunodeficiency virus (HIV)-positive patients receiving anti-retroviral therapy are excluded from this study Human immunodeficiency virus (HIV)-positive patients receiving anti-retroviral therapy are excluded from this study; HIV positive patients not receiving antiretroviral therapy are excluded Known HIV-positive subjects on combination anti-retroviral therapy due to the potential for PK interactions with the study agent. If HIV positive, receipt of anti-retroviral therapy continuously for at least months prior to enrollment Patient on anti-retroviral medications Patients known to be human immunodeficiency virus (HIV) positive who are not receiving anti-retroviral therapy will be excluded Has a known history of human immunodeficiency virus (HIV); HIV-positive patients receiving anti-retroviral therapy are excluded from this study; HIV positive patients not receiving antiretroviral therapy are excluded Known positive serology for human immunodeficiency virus (HIV), due to potential drug-drug interactions between anti-retroviral medications and the study drugs Human immunodeficiency virus (HIV)-positive patients receiving combination anti-retroviral therapy are excluded from the study Human Immunodeficiency Virus (HIV)-infection is not an exclusion criterion if it is controlled with anti-retroviral drugs that are unaffected by concomitant enzalutamide. Known human immunodeficiency virus (HIV)-positive patients are excluded from the study; for patients receiving combination anti-retroviral therapy; screening for HIV status will not be performed Human immunodeficiency virus (HIV)-positive patients receiving combination anti-retroviral therapy are excluded Known HIV positive or on active anti-retroviral therapy Known history of testing positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome. Anti-retroviral agents are known to have potential adverse pharmacokinetic interactions with nivolumab and/or BMS-. IN addition, patients not on anti-retroviral agents, regardless of HIV viral load, are at increased risk of lethal infections with marrow-suppressive therapy including chemotherapy. Testing for HIV must be performed at sites mandated by local requirements. Known human immunodeficiency virus (HIV)-positive patients receiving combination anti-retroviral therapy are excluded from the study Human immunodeficiency virus (HIV)-positive patients receiving combination anti-retroviral therapy are excluded from the study Human immunodeficiency virus (HIV)-positive patients receiving combination anti-retroviral therapy are excluded from the study; note: HIV testing is not required for entry into this protocol Human immunodeficiency virus (HIV)-positive patients receiving combination anti-retroviral therapy are excluded from the study Patients with known human immunodeficiency virus (HIV) infection are ineligible due to risk of pharmacokinetic interactions between anti-retroviral therapy and the study drugs, as well as potential for significant immunosuppression and serious infections with mTOR inhibition Patients known to be human immunodeficiency virus (HIV) positive and receiving highly active anti-retroviral therapy (HAART) Known human immunodeficiency virus (HIV)-positive patients receiving combination anti-retroviral therapy are excluded from the study Human immunodeficiency virus (HIV)-positive patients receiving combination anti-retroviral therapy are excluded from the study; note: HIV testing is not required for entry into this protocol Known human immunodeficiency virus (HIV)-positivity AND actively being treated with highly active anti-retroviral therapy (HAART) Patients with a diagnosis of active human immunodeficiency virus (HIV) infection, on anti-retroviral therapy, or with a cluster of differentiation (CD) count less than are ineligible due to potential interactions between irinotecan and anti-retroviral medications as well as possible immunosuppressive activity of the study treatment; testing is not required in the absence of clinical findings or suspicion HIV-positive patients receiving anti-retroviral therapy are excluded from this study; HIV positive patients not receiving antiretroviral therapy are excluded Individuals with a known history of human immunodeficiency virus (HIV) positivity may be included in the study as long as they are on appropriate highly active anti-retroviral therapy (HAART) therapy Human immunodeficiency virus-positive patients receiving combination anti-retroviral therapy are excluded from the study Human immunodeficiency virus (HIV) positive patients who are not on retroviral therapy will not be excluded from cohort , the normal liver function cohort\r\n* HIV positive patients who are not on retroviral therapy will be excluded from cohorts - Human immunodeficiency virus (HIV)-positive patients receiving anti-retroviral therapy are excluded from this study Human immunodeficiency virus (HIV)-positive patients receiving combination anti-retroviral therapy are excluded Human immunodeficiency virus (HIV) - positive participants receiving anti-retroviral therapy Patients cannot be receiving HAART (highly active anti-retroviral therapy) therapy Human immunodeficiency virus (HIV)-positive patients receiving anti-retroviral therapy are excluded from this study; HIV positive patients not receiving antiretroviral therapy are excluded Known human immunodeficiency virus (HIV)-positive patients receiving combination anti-retroviral therapy are excluded from the study Known human immunodeficiency virus (HIV)-positive patients receiving combination anti-retroviral therapy are excluded from the study Human immunodeficiency virus (HIV)-positive patients receiving combination anti-retroviral therapy are excluded from the study