Within days of treatment initiation: Prothrombin time (PT) and partial thromboplastin time (aPTT) =< . X institutional upper limit of normal (IULN) Prothrombin time (PT) and partial thromboplastin time (PTT) =< . x ULN Prothrombin time (PT)/partial thromboplastin time (PTT) =< times normal; timeline: within weeks prior to enrollment or Prothrombin time (PT)/partial thromboplastin time (PTT) =< . X upper limit of normal (ULN) unless receiving clinically indicated anticoagulant therapy PART I: Prothrombin time (PT)/partial thromboplastin time (PTT) =< . x the upper limits of normal Prothrombin time (PT)/partial thromboplastin time (PTT) > . upper limit of normal (ULN) Prothrombin time (PT)/partial thromboplastin time (PTT) less than . times normal Prothrombin time (PT)/partial thromboplastin time (PTT) =< . x ULN Prothrombin time (PT), partial thromboplastin time (PTT) =< . times upper limit of normal Prothrombin time (PT)/partial thromboplastin time (PTT) ? . times the ULN Within days (+ day window) of enrollment: Prothrombin time (PT) and partial thromboplastin time (PTT) =< . x the institutional upper limit of normal (ULN), (this will not apply to subjects with confirmed Factor XII deficiency) Prothrombin time (PT) and partial thromboplastin time (PTT) must be =< x the upper limit of the institution's normal range, at the time of enrollment Hepatic: Total bilirubin . x ULN; transaminases ? . x ULN (may be up to x ULN if clearly due to liver metastases); prothrombin time (PT) and partial thromboplastin time (PTT) < x (ULN). A Prothrombin Time (PT) or Partial Thromboplastin Time (PTT) within normal range Prothrombin and partial thromboplastin times =< . x upper limit of normal (ULN) prior to biopsy Prothrombin time (PT)/partial thromboplastin time (PTT) =< . x ULN Prothrombin and partial thromboplastin times =< . x normal prior to biopsy Obtained within days prior to registration; prothrombin time and partial thromboplastin time (PT / PTT) ? % increase from institutional ULN Prothrombin time (PT) and partial thromboplastin time (PTT) > % of deviation of institutional ULN Prothrombin time (PT) or partial thromboplastin time (PTT) < . x upper limit of normal (ULN) Prothrombin time (PT) and partial thromboplastin time (PTT) =< . x ULN after correction of nutritional deficiencies that may contribute to prolonged PT/PTT No baseline prothrombin time (PT)/partial thromboplastin time (PTT) abnormalities, coagulopathies, or who are on any blood thinners Prothrombin time (PT) < sec; partial thromboplastin time (PTT) < sec Prothrombin time (PT), partial thromboplastin time (PTT) =< . x ULN Prothrombin time (PT) and partial thromboplastin time (PTT) < % of deviation from institutional upper limit of normal (IULN) Prothrombin time (PT) with normal limits (WNL); if patient is on warfarin for prophylactic clot presentation for indwelling catheter, PT/partial thromboplastin time (PTT) may be +/- % Evidence of bleeding diathesis or coagulopathy as documented by an elevated prothrombin time (PT), partial thromboplastin time (PTT) or bleeding time Prothrombin time (PT)/partial thromboplastin time (PTT) within normal limits (secpatient may be eligible for trial if abnormality is deemed clinically insignificant and cleared for protocol therapy by Hematology Consult service) Prothrombin time (PT)/partial thromboplastin time (PTT) =< . times upper limit of normal range Prothrombin time (PT) and partial thromboplastin time (PTT) =< x normal outside the setting of stable chronic anticoagulation therapy Prothrombin time (PT)/partial thromboplastin time (PTT) =< . x upper limit of normal (ULN) unless receiving clinically indicated anticoagulant therapy ORAL CAVITY SQUAMOUS CELL CARCINOMA COHORT: Prothrombin time (PT) and partial thromboplastin time (PTT) < . x ULN HPV-ASSOCIATED OROPHARYNX SQUAMOUS CELL CARCINOMA: Prothrombin time (PT) and partial thromboplastin time (PTT) < . x ULN Prothrombin time (PT) and/or partial thromboplastin time (PTT) =< . X ULN. Prothrombin time/partial thromboplastin time (PT/PTT) ? . x upper limit of normal (ULN) (unless receiving anticoagulation) Prothrombin time (PT) and partial thromboplastin time (PTT) ? . x of institutional upper limit of normal (ULN) (Note: If coagulopathy is related to disease, this criteria do not apply) within days prior to registration Prothrombin time (PT)/partial thromboplastin time (PTT) < . x normal institutional standard Prothrombin Time (PT) and activated partial thromboplastin time (PTT) ? .x unless therapeutically warranted Prothrombin time (PT)/partial thromboplastin time (PTT) within normal limits (. - . / . - . sec) Prothrombin time (PT) > seconds or partial thromboplastin time (PTT) > seconds Prothrombin time (PT) and partial thromboplastin time (PTT) =< x ULN Prothrombin time (PT) and partial thromboplastin time (PTT) =< . x upper limit of normal (ULN) Prothrombin time (PT) and partial thromboplastin time (PTT) within . times the institutional upper limit of normal Normal coagulation [prothrombin time and partial thromboplastin time within normal limits (%)]. Prothrombin time (PT) or partial thromboplastin time (PTT) test >= . x laboratory upper limit of normal (ULN) within days before the first dose of study treatment Prothrombin time (PT) and partial thromboplastin time (PTT) ? . X ULN after correction of nutritional deficiencies that may have contributed to prolonged PT/PTT. AMKL PATIENTS: Prothrombin time (PT) and partial thromboplastin time (PTT) =< . x ULN Coagulation: Prothrombin time (PT) <. ULN and partial thromboplastin time (PTT) <. ULN Acceptable coagulation studies as demonstrated by prothrombin time (PT) and partial thromboplastin time (PTT) within normal limits (+/-%). Prothrombin time (PT) and partial thromboplastin time (PTT) < .x the ULN Prothrombin time (PT) and partial thromboplastin time (PTT) > % of deviation of institutional upper limit of normal (ULN) Patients must NOT have a prolonged prothrombin time (PT) or partial thromboplastin time (PTT) (greater than . times the institutional upper limit of normal) Prothrombin time (PT) and partial thromboplastin time (PTT) > % of deviation of institutional ULN Other: Prothrombin time (PT) and partial thromboplastin time (PTT) < ULN. Prothrombin time (PT) and partial thromboplastin time (PTT) =< x ULN Prothrombin time (PT)/partial thromboplastin time (PTT) =< . x upper limit of normal (ULN) Prothrombin time (PT)/partial thromboplastin time (PTT) =< . x upper limit of normal (ULN) Normal prothrombin time (PT)/partial thromboplastin time (PTT) prothrombin time (PT) and activated partial thromboplastin time (PTT) ? . x control unless therapeutically warranted Prothrombin time (PT) and partial thromboplastin time (PTT) must not be more than . x upper limit of normal (ULN) within hours prior to enrollment; PT and PTT should be drawn by venipuncture, rather than from a central venous catheter when feasible Prothrombin time (PT) and partial thromboplastin time (PTT) < x normal outside the setting of stable chronic anticoagulation therapy Prothrombin time (PT)/partial thromboplastin time (PTT) =< . x institutional upper limits of normal Prothrombin time (PT) and partial thromboplastin time =< . upper limit of normal (ULN) unless using warfarin for therapeutic anti-coagulation Subjects must have normal coagulation parameters as measured by prothrombin time (PT)/partial thromboplastin time (PTT) Prothrombin time (PT)/INR and partial thromboplastin time (PTT) =< grade within two weeks before initial biopsy of visceral organs Prothrombin and partial thromboplastin times =< . x normal prior to biopsy Prothrombin time (PT) and partial thromboplastin time (PTT) =< . X upper limit normal (ULN) Prothrombin time (PT) and partial thromboplastin time (PTT) < x normal outside the setting of stable chronic anticoagulation therapy Prothrombin time (PT) and partial thromboplastin time (PTT) =< % of control, unless patient has the presence of a lupus anticoagulant Prothrombin time (PT), partial thromboplastin time (PTT) less than or equal to to . x upper limit of normal, CTCAE v . grade except for patients on therapeutic anticoagulation Prothrombin time (PT)/partial thromboplastin time (PTT) =< . X ULN Coagulation status: prothrombin time (PT) ? . ULN or INR within normal limits; and partial thromboplastin time (PTT) ? . ULN PART I: Absolute neutrophil count (ANC), hemoglobin, platelet, total bilirubin, creatinine, transaminase (aspartate aminotransferase [AST]/alanine aminotransferase [ALT]), prothrombin time (PT), partial thromboplastin time (PTT), urine uric acid, urine pH, urine oxalate must be within standard normal ranges Prothrombin time (PT)/partial thromboplastin time (PTT) < . x upper limit of normal (ULN) Prothrombin time (PT) or partial thromboplastin time (PTT) < . x institutional upper limit of normal (IULN) Prothrombin time (PT) =< seconds above upper limit of normal (ULN) and partial thromboplastin time (PTT) =< seconds above ULN Prothrombin time (PT)/partial thromboplastin time (PTT) within normal limits (WNL) of the institution Prothrombin time (PT) or partial thromboplastin time (PTT) > . x the upper limit of normal, except if the patient is on therapeutic anticoagulation, in which case they should demonstrate stability of PT/PTT for at least two weeks Have a bleeding disorder as determined by prothrombin time (PT) > . seconds, partial thromboplastin time (PTT) > seconds, and platelet count < , platelets per microliter of circulating blood Prothrombin time (PT) and partial thromboplastin time (PTT) > . x ULN Prothrombin time (PT) and partial thromboplastin (PTT) =< . x IULN Prothrombin time (PT) and partial thromboplastin time (PTT) =< . x institutional upper limit of normal Prothrombin time (PT)/partial thromboplastin time (PTT) within normal institutional limits Presence of coagulopathy (prothrombin time [PT] or partial thromboplastin time [PTT] > . x upper limit of normal) Thrombin time (TT), prothrombin time (PT), or partial thromboplastin time (PTT) > x upper limit of normal Patients not taking warfarin must have prothrombin time (PT)/partial thromboplastin time (PTT) levels =< . times the upper limit of normal provided by the reference laboratory performing the test Prothrombin time (PT)/partial thromboplastin time (PTT) within normal institutional limits PT/PTT/INR (prothrombin time/partial thromboplastin time) without clinically significant abnormalities after review by the study physicians Contraindication to biopsy:\r\n* Bleeding disorders\r\n* Prothrombin time (PT)/partial thromboplastin time (PTT) >= . times the upper limit of normal\r\n* Artificial heart valve Patients with coagulopathies who are at increased risk for bleeding or on active anti-coagulation therapy (platelets less than , per mm^ or prothrombin time [PT]/partial thromboplastin time [PTT] greater than . times the upper normal limit [UNL]); patients are eligible if the underlying cause is correctable Prothrombin time (PT)/partial thromboplastin time (PTT) =< the institution ULN Coagulopathy (prothrombin time [PT] or partial thromboplastin time [PTT] > . x upper limit of normal) Prothrombin time (PT), partial thromboplastin time (PTT) =< . times upper limit of normal