Prothrombin time (PT)/ international normalized ration (INR) < . x ULN and partial thromboplastin time (PTT) (activated [a]PTT) < . x ULN Patients must have the following tests within days prior to registration to obtain baseline measurements:\r\n* Prothrombin time (PT)/partial thromboplastin time (PTT)/international normalized ratio (INR)/fibrinogen (all patients)\r\n* Neurologic assessment Partial thromboplastin time (PTT) / prothrombin time (PT) =< . x ULN or international normalized ratio (INR) < . x ULN for patients who are not receiving therapeutic anticoagulation. Patients receiving therapeutic anticoagulation should be on a stable dose. Patients must have adequate coagulation (international normalized ratio (INR) or prothrombin time (PT), partial thromboplastin time (PTT) ?. times ULN) The subject has prothrombin time (PT)/international normalized ratio (INR) or partial thromboplastin time (PTT) test >= . x the laboratory ULN within days before the first dose of cabozantinib Prothrombin time (PT) / partial thromboplastin time (PTT); PT such that international normalized ratio (INR) =< . x ULN (unless a patient is on therapeutic warfarin) or a PTT =< . x ULN The subject has prothrombin time (PT)/international normalized ratio (INR) or partial thromboplastin time (PTT) test >= . x the laboratory ULN within days before the first dose of study treatment Prothrombin time (PT)/partial thromboplastin time (PTT) ? . ULN (unless receiving anticoagulation therapy, if receiving anticoagulation therapy, eligibility will be based upon international normalized ratio [INR]). The participant has prothrombin time (PT)/international normalized ratio (INR) or partial thromboplastin time (PTT) test >= . x the laboratory ULN within days before the first dose of study treatment Adequate coagulation function, defined by prothrombin time (PT)/international normalized ratio (INR), partial thromboplastin time (PTT), or thrombin time (TT) of ?. ULN Prothrombin time (PT)/international normalized ratio (INR) < . x ULN and partial thromboplastin time (PTT) (activated [a]PTT) < . x ULN International normalized ratio (INR) ? . and partial thromboplastin time (PTT) ? . x ULN. Prothrombin time (PT) may be used instead of INR if ? . x ULN. PHASE I: Prothrombin time (PT) (or international normalized ratio [INR]) and partial thromboplastin time (PTT) =< . x ULN Subject has prothrombin time/International Normalized Ratio or partial thromboplastin time test results at screening ?. x ULN. Prothrombin time (PT) or international normalized ratio (INR), partial thromboplastin time (PTT) =< . x ULN Adequate coagulation function as defined by International Normalized Ratio ?. or prothrombin time ?. x ULN, and partial thromboplastin time ?. x ULN Coagulation parameters: international normalized ratio (INR) > , prothrombin time (PT) and partial thromboplastin time (PTT) > % of deviation of institutional ULN Prothrombin time (PT)/ international normalized ratio (INR) or partial thromboplastin time (PTT) test >= . x the laboratory ULN within days before the first dose of study treatment. Prothrombin time (PT)/international normalized ratio (INR) or partial thromboplastin time (PTT) test =< . x ULN Within days before the first dose of study treatment: Prothrombin time (PT)/international normalized ratio (INR) or partial thromboplastin time (PTT) test < . x the ULN within days before the first dose of study treatment Prothrombin time (PT)/international normalized ratio (INR) < . x ULN and partial thromboplastin time (PTT) (activated [a]PTT) < . x ULN (unless abnormalities are unrelated to coagulopathy or bleeding disorder). Prothrombin time/international normalized ratio (PT/INR) < . x ULN and partial thromboplastin time (PTT) (activated [a]PTT) < . x ULN FULL STUDY INCLUSION CRITERIA: International normalized ratio (INR) or prothrombin time (PT) =< . x ULN (Common Terminology Criteria for Adverse Events [CTCAE] grade =< )\r\n* Note: patients on stable dose of anti-coagulation therapy will be allowed to participate if they have no sign of bleeding or clotting and INR / PT and partial thromboplastin time (PTT) / activated (a)PTT test results are compatible with the acceptable benefit-risk ratio at the investigators discretion Prothrombin time (PT)/ international normalized ratio (INR) and partial thromboplastin time (PTT) test =< . ULN Prothrombin time (PT) or international normalized ratio (INR) or partial thromboplastin time ?. x ULN. Patients on a stable, maintenance regimen of anticoagulant therapy for at least days prior to study drug administration may have PT/INR measurements >. x ULN if, in the opinion of the Investigator, the patient is suitable for the study. An adequate rationale must be provided to the Sponsor prior to randomization. Abnormal coagulation parameters (prothrombin time [PT] > seconds, partial thromboplastin time [PTT] > seconds, and/or international normalized ratio [INR] > .) Prothrombin time (PT)/international normalized ration (INR) < . x ULN and partial thromboplastin time (PTT) (activated [a]PTT) < . x ULN The subject has prothrombin time (PT)/international normalized ratio (INR) or partial thromboplastin time (PTT) test >= . x the laboratory ULN within days before the first dose of study treatment Prothrombin time (PT) with an international normalized ratio (INR) =< . and a partial thromboplastin time (PTT) of =< . times the ULN; for patients on full-dose oral anti-coagulation (such as warfarin or rivaroxaban), in-range INR (usually between and ) and a PTT < . times the ULN Prothrombin time (PT)/international normalized ratio (INR) and partial thromboplastin time (PTT) =< . X ULN; subjects receiving anticoagulation treatment may be allowed to participate with INR established within the therapeutic range prior to randomization Prothrombin time (PT)/international normalized ratio (INR) or partial thromboplastin time (PTT) test >= . x the laboratory ULN within days before the first dose of study treatment Prothrombin time (PT)/international normalized ratio (INR) and partial thromboplastin time (PTT) =< . x institutional ULN The subject has prothrombin time (PT)/ International Normalized Ratio (INR) or partial thromboplastin time (PTT) test >= . x the laboratory ULN within days before the first dose of study treatment Prothrombin time (PT)/international normalized ratio (INR) and partial thromboplastin time (PTT) =< . x institutional ULN The subject has prothrombin time (PT)/International Normalized Ratio (INR) or partial thromboplastin time (PTT) test >= . x the laboratory ULN within days before the first dose of study treatment Abnormal prothrombin time (PT) (international normalized ratio [Inr]) > . INR or partial thromboplastin time (PTT) > seconds (sec) (may be corrected with flash frozen plasma [FFP], cryoprecipitate, vitamin K, etc) Prothrombin time (PT)/international normalized ratio (INR) < . x institutional ULN and partial thromboplastin time (PTT) (activated [a]PTT) < . x institutional ULN Prothrombin time (PT)/international normalized ratio (INR); partial thromboplastin time (PTT) =< .; =< . x ULN Prothrombin time (PT)/international normalized ratio (INR) and partial thromboplastin time (PTT) < . x ULN for age Prothrombin time (PT)/international normalized ratio (INR) and partial thromboplastin time (PTT) ? . x ULN (except for subjects receiving anticoagulation therapy) International normalized ratio (INR) or prothrombin time (PT) =< . x ULN unless on anticoagulation therapy, in which case PT or partial thromboplastin time (PTT) should be in the therapeutic range The subject has prothrombin time (PT)/institutional normalized ratio (INR) or partial thromboplastin time (PTT) test >= . x the laboratory ULN within days before the first dose of study treatment INR (prothrombin time ratio) or partial thromboplastin time (PTT) > . x ULN (Please note: patients with hematopoietic cell transplantation (Hct) < %, WBC < /mm/^ and platelets < ,/mm^ immediately prior to leukapheresis. The procedure may be deferred.) Prothrombin time (PT)/international normalized ratio (INR) less than or equal to . x ULN and partial thromboplastin time (PTT) (activated [a]PTT) less than or equal to . x ULN Prothrombin time (PT)/international normalized ratio (INR) and partial thromboplastin time (PTT) performed within weeks prior to starting study therapy must be =< . x ULN The subject has prothrombin time (PT)/international normalized ratio (INR) or partial thromboplastin time (PTT) test >= . x the laboratory ULN =< days before the first dose of study treatment International normalized ratio (INR) or partial thromboplastin time (PTT)/prothrombin time (PT) =< . ULN, unless the patient is on stable therapeutic dose of warfarin International normalized ratio INR/ prothrombin time (PT)/ partial thromboplastin time (PTT) each < . x ULN Prothrombin time/international normalized ratio (PT/INR) and partial thromboplastin time (PTT) =< . x institutional ULN Prothrombin time (PT)/international normalized ratio (INR) and partial thromboplastin time (PTT) =< . x institutional ULN; subjects receiving anticoagulation treatment may be allowed to participate with INR established within the therapeutic range prior to randomization The subject has prothrombin time (PT)/international normalized ratio (INR) or partial thromboplastin time (PTT) test results at screening >= . x the laboratory ULN Active bleeding disorder as determined by abnormal prothrombin time, partial thromboplastin time, international normalized ratio (INR) or platelet count (as determined by institutional lab parameters) at the time of screening Prothrombin time (PT)/international normalized ratio (INR) and partial thromboplastin time (PTT) =< . x institutional ULN Prothrombin time (PT)/international normalized ratio (INR) and partial thromboplastin time (PTT) =< . x institutional ULN; subjects receiving anticoagulation treatment may be allowed to participate with PT/INR/PTT established within the therapeutic range prior to randomization; subjects will be eligible if it is determined by a hematologist that the cause is not associated with clinical bleeding (e.g., deficiency of factor XII), within weeks of the first dose of study treatment Prothrombin time (PT)/international normalized ratio (INR) and partial thromboplastin time (PTT) =< . x institutional ULN; subjects receiving anticoagulation treatment may be allowed to participate with INR established within the therapeutic range prior to randomization Prothrombin time (PT) such that international normalized ratio (INR) is =< . x ULN (or an in-range INR, usually between and , if a patient is on a stable dose of therapeutic warfarin) and a partial thromboplastin time (PTT) < . x ULN Other: INR (prothrombin time ratio) or partial thromboplastin time (PTT) >. x ULN Other: INR (prothrombin time ratio) or partial thromboplastin time (PTT) >. x ULN. Other: INR (prothrombin time ratio) or partial thromboplastin time (PTT) >. x ULN Coagulation parameters: international normalized ratio (INR) =< , prothrombin time (PT) and partial thromboplastin time (PTT) < . X institutional ULN Prothrombin time (PT)/partial thromboplastin time (PTT)/international normalized ratio (INR) =< . x ULN The subject has prothrombin time (PT)/international normalized ratio (INR) or partial thromboplastin time (PTT) test >= . the laboratory ULN within days before the first dose of study treatment The following laboratory values obtained =< days prior to randomization\r\n* Prothrombin time (PT)/partial thromboplastin time (PTT)/international normalized ratio (INR) =< . X ULN if not anticoagulated; within local institutional guidelines per local physician if anticoagulated Prothrombin time (PT)/international normalized ratio (INR) and partial thromboplastin time (PTT) =< . x ULN unless on anticoagulation medication with stable dosing for at least one month; in addition, patient must be able to stop taking medication for up to a week in order to have percutaneous biopsies of tumor tissue performed No patients will have coagulation parameters: international normalized ratio (INR) > , prothrombin time (PT) and partial thromboplastin time (PTT) > % deviation of the institutional ULN Prothrombin time (PT)/international normalized ratio (INR) < . x ULN and partial thromboplastin time (PTT) < . x ULN Prothrombin time (PT)/international normalized ratio (INR) and partial thromboplastin time (PTT) =< . x institutional ULN International normalized ratio (INR) < , prothrombin time (PT) < sec, and partial thromboplastin time (PTT) < sec The subject has prothrombin time (PT)/international normalized ratio (INR) or partial thromboplastin time (PTT) test >= . x the institutional ULN =< days before the first dose of study treatment, unless PT/PTT prolongation known to be secondary to conditions not associated with increased bleeding risk (as on antiphospholipid antibody syndrome) The subject has prothrombin time (PT)/international normalized ratio (INR) or partial thromboplastin time (PTT) test results at screening >= . the laboratory ULN within days before the first dose of study treatment The participant has prothrombin time (PT)/international normalized ratio (INR) or partial thromboplastin time (PTT) test results at screening >= . X the laboratory ULN Prothrombin time (PT) such that international normalized ratio (INR) is =< . (or an in-range INR, usually between and , if a patient is on a stable dose of therapeutic warfarin for management of venous thrombosis) and a partial thromboplastin time (PTT) < . x ULN Prothrombin time (PT)/international normalized ratio (INR)/partial thromboplastin time (PTT) within . X the ULN unless a subject is receiving Coumadin and has stable INR which is in range for the desired level of anticoagulation Subjects must have adequate coagulation as assessed by: international normalized ratio (INR) or prothrombin time (PT) <=. times ULN (CTCAE Grade <=), partial thromboplastin time (PTT) <=. x ULN (CTCAE Grade <=) International normalized ratio (INR) > , prothrombin time (PT) and partial thromboplastin time (PTT) > % of deviation of institutional ULN Normal partial thromboplastin time (PTT) and either international normalized ratio (INR) or prothrombin time (PT) < . x ULN The participant has prothrombin time (PT)/international normalized ratio (INR) or partial thromboplastin time (PTT) test >= . the laboratory ULN within days before the first dose of study treatment The subject has prothrombin time (PT)/international normalized ratio (INR) or partial thromboplastin time (PTT) test results at screening >= . x the laboratory ULN TPI may interfere with Coumadin dosing and patients who are taking this combination will require monitoring of their prothrombin time (PT), partial thromboplastin time (PTT), and international normalized ratio (INR) The subject has prothrombin time (PT)/international normalized ratio (INR) or partial thromboplastin time (PTT) test >= . x the laboratory ULN within days before the first dose of study treatment Prothrombin time (PT)-international normalized ratio (INR)/partial thromboplastin time (PTT) < . x ULN except in patients receiving active anticoagulation Coagulation parameters: International normalised ratio (INR) < and partial prothrombin Time (PTT) = xULN Prothrombin time (PT)/International normalized ratio (INR) and partial thromboplastin time (PTT) <=.xULN Coagulation parameters: International normalized ratio (INR) > , prothrombin time (PT) and partial thromboplastin time (PTT) > % of deviation of institutional ULN The subject has prothrombin time (PT)/international normalized ratio (INR) or partial thromboplastin time (PTT) test results at screening that are >= . x ULN Prothrombin time (PT)/international normalized ratio (INR), partial thromboplastin time (PTT) =< . x ULN Prothrombin time (PT)/international normalized ratio (INR) < . x ULN and partial thromboplastin time (PTT) (activated [a]PTT) < . x ULN Prothrombin time (PT)/international normalized ratio (INR) and partial thromboplastin time (PTT) =< . x institutional ULN Prothrombin time (PT) < . ULN or international normalized ratio (INR) < . and partial thromboplastin time (PTT) < . ULN; unless the patient is on a therapeutic anticoagulant Patients with abnormal prothrombin time (PT)/international normalized ratio (INR)/partial thromboplastin time (PTT) or bleeding diathesis